文章摘要
阳益德,付连国,王政和,王烁,孟祥坤,马蕊,马冬梅,马军.超重/肥胖成年人体脂与血压关联中血脂中介效应的分析[J].中华流行病学杂志,2015,36(7):691-694
超重/肥胖成年人体脂与血压关联中血脂中介效应的分析
Mediating effect of blood lipids on correlation between body fat and blood pressure among overweight adults
投稿时间:2015-01-06  
DOI:10.3760/cma.j.issn.0254-6450.2015.07.006
中文关键词: 肥胖;血脂;体脂率;血压;中介效应
英文关键词: Obesity;Blood lipids;Percentage of body fat;Blood pressure;Mediating effect
基金项目:
作者单位E-mail
阳益德 100191 北京大学公共卫生学院 北京大学儿童青少年卫生研究所  
付连国 蚌埠医学院预防医学系  
王政和 100191 北京大学公共卫生学院 北京大学儿童青少年卫生研究所  
王烁 100191 北京大学公共卫生学院 北京大学儿童青少年卫生研究所  
孟祥坤 100191 北京大学公共卫生学院 北京大学儿童青少年卫生研究所  
马蕊 100191 北京大学公共卫生学院 北京大学儿童青少年卫生研究所  
马冬梅 100191 北京大学公共卫生学院 北京大学儿童青少年卫生研究所  
马军 100191 北京大学公共卫生学院 北京大学儿童青少年卫生研究所 majunt@bjmu.edu.cn 
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中文摘要:
      目的 探索超重/肥胖成年人体脂与血压关联中血脂的中介效应。方法 选取20~55岁超重/肥胖个体作为研究对象,测量其血压、血脂、体脂率指标,采用中介效应模型分析体脂率与血压关联中血脂的中介效应。结果 男性和女性体脂率与SBP、DBP均呈正相关(SBP: β值分别为0.208 3和0.188 4,DBP: β值分别为0.205 2和0.209 6,P值均<0.001)。男性体脂率与HDL-C水平呈负相关(β =-0.142 2,P<0.01),与LDL-C水平呈正相关(β =0.180 5,P<0.001);女性体脂率与TC、LDL-C水平均呈正相关(β值分别为0.172 1和0.233 5,P<0.001)。控制体脂率后,男女性TC、TG水平与DBP均呈正相关(男: β值分别为0.095 6和0.090 5,女: β值分别为0.117 6和0.083 1,P值均<0.05),且女性TG水平与SBP呈正相关(β =0.127 2,P<0.001);女性体脂率与DBP的关联中,LDL-C水平具有中介效应(中介效应值为0.019 4,P<0.05),中介效应百分比为9.26%。结论 体脂率与血压呈正相关,男性体脂率与血压关联中血脂无中介效应,女性体脂率与血压关联中LDL-C水平具有中介效应。
英文摘要:
      Objective To understand the mediating effect of blood lipids on the correlation between body fat and blood pressure among overweight adults. Methods Overweight and obese subjects aged 20-55 years who had lived in Beijing for at least 1 year were recruited in this study, Body mass index (BMI) was used as a screening indicators. The percentage of body fat (PBF) was measured for the subjects by using dual energy X-ray absorptiometry(DXA). Mediating effect analysis was conducted to analyze the mediating effect of blood lipids on correlation between PBF and systolic blood pressure (SBP) as well as diastolic blood pressure (DBP). Results After adjusting for age, PBF was positively correlated with SBP and DBP in both males (β=0.208 3, β=0.205 2, P<0.001) and females (β=0.188 4, β=0.209 6, P<0.001). In male subgroup, PBF was negatively correlated with HDL-C level, but positively correlated with LDL-C level (β=-0.142 2, P<0.01 and β =0.180 5, P<0.001), while in female subgroup, PBF was positively correlated with both TC level and LDL-C level (β=0.172 1, P<0.001 and β =0.233 5, P<0.001). With PBF controlled, TC and TG levels were positively correlated with DBP in both males and females (β=0.095 6, 0.090 5 for males, β=0.117 6, 0.083 1 for females, P<0.05), and TG level was positively correlated with SBP in females (β=0.127 2, P<0.001). Further analysis indicated there was a significant mediating effect of LDL-C on correlation between PBF and DBP in females, with the mediating effect value of 0.019 4 (P<0.05). The ratio of mediating effect was 9.26%. Conclusion PBF was positively correlated with blood pressure, but blood lipids had no mediating effect on the correlation between PBF and blood pressure in males, while LDL-C level had mediating effect on PBF and blood pressure in females.
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