文章摘要
武轶群,李帅,刘括,唐迅,方凯,李娜,李劲,吴涛,陈大方,胡永华.白三烯A4水解酶基因多态性与缺血性脑卒中的关联研究[J].中华流行病学杂志,2015,36(8):786-789
白三烯A4水解酶基因多态性与缺血性脑卒中的关联研究
Study on the association between leukotriene A4 hydrolase gene polymorphism and ischemic stroke
收稿日期:2015-01-29  出版日期:2015-08-11
DOI:10.3760/cma.j.issn.0254-6450.2015.08.003
中文关键词: 脑卒中, 缺血性;白三烯A4水解酶;单核苷酸多态性;遗传流行病学
英文关键词: Ischemic stroke;Leukotriene A4 hydrolase;Single nucleotide polymorphism;Genetic epidemiology
基金项目:国家自然科学基金(81172744, 81230066);教育部博士点基金(20120001120029)
作者单位E-mail
武轶群 100191 北京大学公共卫生学院流行病与卫生统计学系  
李帅 100191 北京大学公共卫生学院流行病与卫生统计学系  
刘括 100191 北京大学公共卫生学院流行病与卫生统计学系  
唐迅 100191 北京大学公共卫生学院流行病与卫生统计学系  
方凯 100191 北京大学公共卫生学院流行病与卫生统计学系  
李娜 北京市房山区科学技术委员会  
李劲 100191 北京大学公共卫生学院流行病与卫生统计学系  
吴涛 100191 北京大学公共卫生学院流行病与卫生统计学系  
陈大方 100191 北京大学公共卫生学院流行病与卫生统计学系  
胡永华 100191 北京大学公共卫生学院流行病与卫生统计学系 yhhu@bjmu.edu.cn 
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中文摘要:
      目的 探讨白三烯A4水解酶(LTA4H)基因多态性与缺血性脑卒中(IS)及其亚型的关联性。方法 采用表型不一致同胞对研究设计, 分析4个LTA4H基因单核苷酸多态性位点(rs2072512、rs2540489、rs2540500和rs6538697)与IS及其亚型的关联关系。采用广义估计方程(GEE)进行多因素分析, 采用条件logistic回归模型和以家系为基础的关联检验(FBAT)进行关联分析。结果 对234个家系所组成的356对表型不一致同胞对进行分析, 发现高血压、糖尿病、高脂血症的患病情况与IS的发病风险存在相关。各位点与IS的关联分析发现, 在加性和隐性模型下, rs2540489基因型与IS的关联具有统计学意义, G等位基因是保护因素(加性模型OR=0.62, 95%CI: 0.41~0.94;隐性模型OR=0.48, 95%CI: 0.23~1.02);rs2540489 基因型与大动脉粥样硬化型(LAA)IS的关联具有统计学意义, G等位基因是保护因素(加性模型OR=0.48, 95%CI: 0.24~0.95;隐性模型OR=0.25, 95%CI: 0.07~0.93);在调整年龄、性别等其他因素后, 以上关联关系仍然存在。结论 LTA4H基因 rs2540489位点多态性与大动脉粥样硬化型IS存在关联。
英文摘要:
      Objective To investigate the association between polymorphism of leukotriene A4 hydrolase (LTA4H) gene among ischemic stroke patients and the related subtypes in the discordant sib pairs. Methods Families including ischemic stroke patients and their siblings were recruited. Four single nucleotide polymorphisms (SNPs) of LTA4H as rs2072512, rs2540489, rs2540500 and rs6538697 were selected. Generalized estimating equation (GEE) was used to adjust for in-family correlation in the analysis of discordant sib pairs. Conditional logistic regression model and family based association test (FBAT) were both used to test the associations of LTA4H gene with ischemic stroke and its subtypes. Results In total, data from 356 discordant sib pairs from 234 ischemic stroke patient pedigrees were analyzed. Results of GEE showed that hypertension, diabetes mellitus and hyperlipoidemia were associated with ischemic stroke. According to the association test results, rs2540489 G allele was found to be associated with ischemic stroke, both in the additive model (OR=0.62, 95%CI: 0.41-0.94) and in the recessive model (OR=0.48, 95%CI: 0.23-1.02). For two main ischemic stroke subtypes, rs2540489 G allele was found to be associated with large-artery atherosclerosis stroke in the additive model (OR=0.48, 95%CI: 0.24-0.95) and in the recessive model (OR=0.25, 95%CI: 0.07-0.93). After adjusting age, sex and other factors, the associations mentioned above, still existed. Conclusion rs2540489 polymorphism in LTA4H gene seemed to be associated with large-artery atherosclerosis stroke.
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