文章摘要
叶佩玉,闫银坤,丁文清,董虹孛,刘琴,黄贵民,米杰.中国儿童青少年代谢综合征患病率Meta分析[J].中华流行病学杂志,2015,36(8):884-888
中国儿童青少年代谢综合征患病率Meta分析
Prevalence of metabolic syndrome in Chinese children and adolescents: a Meta-analysis
收稿日期:2015-01-18  出版日期:2015-08-11
DOI:10.3760/cma.j.issn.0254-6450.2015.08.025
中文关键词: 代谢综合征;儿童;青少年;患病率;Meta分析
英文关键词: Metabolic syndrome;Children;Adolescents;Prevalence;Meta-analysis
基金项目:国家自然科学基金(81172746)
作者单位E-mail
叶佩玉 100020 北京, 首都儿科研究所流行病学研究室  
闫银坤 100020 北京, 首都儿科研究所流行病学研究室  
丁文清 100020 北京, 首都儿科研究所流行病学研究室
宁夏医科大学公共卫生学院 
 
董虹孛 100020 北京, 首都儿科研究所流行病学研究室  
刘琴 100020 北京, 首都儿科研究所流行病学研究室  
黄贵民 100020 北京, 首都儿科研究所流行病学研究室  
米杰 100020 北京, 首都儿科研究所流行病学研究室 jiemi@vip.163.com 
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中文摘要:
      目的 通过Meta分析了解我国儿童青少年MS的流行现状, 为早期防治提供科学依据。 方法 检索2004-2014年在中国期刊全文数据库(CNKI)、万方数据资源系统(Wanfangdata)、维普数据库(VIP)及PubMed中收录的有关中国地区儿童青少年MS患病率研究的文献。根据加强观察性流行病学研究报告规范(STROBE)声明中横断面研究评价标准进行文献质量评价, 采用Stata 12.0软件进行数据合并估算患病率, 并对性别、体重状态等因素进行亚组分析, 采用漏斗图及Egger检验发表偏倚, 通过排除其中任意一篇文献对合并效应值的影响进行敏感性分析。 结果 共纳入19篇文献(5篇英文、14篇中文)。依据国际糖尿病联盟(IDF)标准、美国国家胆固醇教育计划成人治疗专家组Ⅲ修订(NCEPⅢ)标准、中国儿童青少年代谢综合征定义和防治建议(CHN2012)标准, 我国儿童青少年MS患病率分别为1.8%、2.6%及2.0%。按IDF标准, 男、女童MS患病率分别为2.9%、1.8%, 正常、超重、肥胖儿童中MS患病率分别为0.2%、4.7%、17.3%。NCEPⅢ标准、CHN2012标准结果均呈现男生MS患病率高于女生、肥胖组MS患病率> 超重组> 正常组。 结论 儿童青少年MS呈流行趋势, 应用不同诊断标准对MS检出率影响较大。肥胖是MS的重要危险因素, 因此应遏制肥胖, 对儿童超重、肥胖尽早识别干预, 以减少儿童MS的发生。
英文摘要:
      Objective To evaluate the prevalence of metabolic syndrome(MS) in Chinese children and adolescents to provide scientific basis for early prevention of MS in the related populations. Methods Studies on CNKI, Wanfangdata, VIP and PubMed databases on related prevalence of metabolic syndrome in Chinese children and adolescents between 2004-2014 were searched. Quality of literatures was evaluated according to the cross-sectional study standard in Strengthening the Reporting of Observational Studies in Epidemiology(STROBE) statement. Stata 12.0 software was used to estimate the prevalence of MS, as well as on gender, weight and other factors to make subgroup analysis. According to funnel plot and Egger assess publication bias, sensitivity analysis performed by excluding the impact of any article was generated by the combined effect of the value of literature. Results This study included 19 papers from the literature (5 in English, 14 in Chinese). According to International Diabetes Federation(IDF), National Cholesterol Education ProgramⅢ (NCEPⅢ) and The definition and prevention recommends of metabolic syndrome in Chinese children and adolescents(CHN2012), the prevalence rates of MS in Chinese children were seen as 1.8%, 2.6% and 2.0%. According to IDF, the prevalence rates of MS appeared 2.9% in boys and 1.8% in girls, 0.2% in children with normal weight, 4.7% in overweight and 17.3% in obesity. Both the results from NCEPⅢ and CHN2012 showed that the prevalence rates of MS as boys>girls, obesity> overweight> normal weight. Conclusion Prevalence of MS in Chinese children and adolescents showed a general trend. Data under different standards showed different prevalence rates. Obesity appeared an important risk factor of MS, suggesting that in order to control obesity in children, attention should be paid to identifying and carrying out effective interventions on children under overweight or obesity.
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