| 黄清,刘小娟,冯洁,文延斌,贺威,刘运海.TNFSF4基因多态性RS3861950与无症状颈动脉易损斑块易感性研究[J].中华流行病学杂志,2015,36(9):998-1001 |
| TNFSF4基因多态性RS3861950与无症状颈动脉易损斑块易感性研究 |
| Association between tumor necrosis factor superfamily member 4 gene polymorphism and risk of asymptomatic carotid vulnerable plaque in a Chinese population |
| 收稿日期:2015-07-03 出版日期:2015-09-10 |
| DOI：10.3760/cma.j.issn.0254-6450.2015.09.019 |
| 中文关键词: 颈动脉易损斑块 肿瘤坏死因子超家族第4成员基因 动脉粥样硬化 脑梗死 |
| 英文关键词: Carotid vulnerable plaque Tumor necrosis factor superfamily member 4 gene Atherosclerosis Cerebral infarction |
| 基金项目:国家自然科学基金(81400978) |
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| 中文摘要: |
| 目的 进一步明确肿瘤坏死因子超家族第4成员(TNFSF4)基因单核苷酸多态性(SNP)在无症状颈动脉易损斑块中的作用,以及对动脉粥样硬化性脑梗死早期预警的意义。方法 利用颈动脉超声筛选无脑卒中症状和体征的颈动脉易损斑块患者510例(病例组),以及性别年龄匹配的无颈动脉易损斑块的健康体检人群485例(对照组),采用TAQMAN-PCR方法检测TNFSF4基因SNP rs3850641、rs3861950基因型。结果 两位点的基因型分布均符合Hardy-Weinberg平衡检验。TNFSF4基因rs3861950位点CC/TT基因型在病例组和对照组中分别为7.1%/57.8%和2.8%/67.6%,两者差异有统计学意义(χ2=25.28,P< 0.000 1);C/T等位基因频率两组比较差异亦有统计学意义(χ2=9.13,P=0.003;OR=1.41,95%CI:1.12～1.76)。TNFSF4 基因rs3850641位点AA/GG基因型在病例组和对照组中分别为68.7%/3.4%和64.8%/31.4%,两者差异无统计学意义(χ2=1.73,P=0.42);A/G等位基因频率两组比较差异亦无统计学意义(χ2=1.47,P=0.225;OR=1.16,95%CI:0.92～1.46)。结论 TNFSF4基因SNP位点rs3861950可能与中国湖南省人群颈动脉易损斑块形成的发生密切相关。TNFSF4基因多态性可参与大动脉粥样硬化型脑梗死的发生。 |
| 英文摘要: |
| Objective Vulnerable plaque of carotid artery is one of the risk factors of atherosclerotic cerebral infarction. Detection and treatment of vulnerable atherosclerotic plaque of carotid artery before symptoms of cerebral infarction is an effective way to prevent atherosclerotic cerebral infarction. Tumor necrosis factor superfamily member 4 (TNFSF4) plays a key role in the process of atherosclerosis,a common risk factor for both myocardial and cerebral infarctions. Studies have indicated that the single nucleotide polymorphism (SNP) rs3850641 in TNFSF4 is associated with higher risk of myocardial infarction and SNP rs3861950 in TNFSF4 is associated with higher risk of atherosclerosis cerebral infarction (ACI),but little is known about the association between TNFSF4 variations and vulnerable plaque of carotid artery. Methods A case-control study involving 510 patients with asymptomatic vulnerable plaque of carotid artery and 485 age and sex matched healthy subjects without vulnerable plaque of carotid artery was conducted in Hunan province. Asymptomatic vulnerable plaque of carotid artery means vulnerable plaque of carotid artery without cerebral infarction. Two SNPs of TNFSF4,rs3850641 and rs3861950,were genotyped by the TaqMan SNP genotyping method,and verified partly by Genomic DNA Sequencing. Results The results revealed a significant allelic association between rs3861950 and asymptomatic vulnerable plaque of carotid artery in case group(χ2=9.13,P=0.003;OR=1.41,95%CI:1.12-1.76). Compared with control subjects,the difference in genotype was significant in case group (χ2=25.28,P< 0.000 1). However,there was no significant association between rs3850641 and asymptomatic vulnerable plaque of carotid artery(OR=1.16,95%CI:0.92-1.46;χ2=1.47,P=0.225). Conclusion TNFSF4 gene polymorphism rs3861950 was associated with the risk of vulnerable plaques of carotid artery in a Chinese population,which might be middle phenotype indicating higher risk of cerebral infarction. |
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