文章摘要
胡如英,龚巍巍,王蒙,潘劲,武海滨,费方荣,何青芳,俞敏.2型糖尿病与恶性肿瘤发病风险关系的队列研究[J].中华流行病学杂志,2015,36(12):1384-1386
2型糖尿病与恶性肿瘤发病风险关系的队列研究
Association between type 2 diabetes mellitus and risk of cancers: a cohort study
收稿日期:2015-05-14  出版日期:2015-12-15
DOI:10.3760/cma.j.issn.0254-6450.2015.12.014
中文关键词: 糖尿病,2型  恶性肿瘤  发病风险  队列研究
英文关键词: Type 2 diabetes mellitus  Cancer  Onset risk  Cohort study
基金项目:中华医学会临床医学科研专项(13040530438)
作者单位E-mail
胡如英 310051 杭州, 浙江省疾病预防控制中心  
龚巍巍 310051 杭州, 浙江省疾病预防控制中心  
王蒙 310051 杭州, 浙江省疾病预防控制中心  
潘劲 310051 杭州, 浙江省疾病预防控制中心  
武海滨 310051 杭州, 浙江省疾病预防控制中心  
费方荣 310051 杭州, 浙江省疾病预防控制中心  
何青芳 310051 杭州, 浙江省疾病预防控制中心  
俞敏 310051 杭州, 浙江省疾病预防控制中心 myu@cdc.zj.cn 
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中文摘要:
      目的 探讨2型糖尿病与恶性肿瘤发病风险之间的关系。方法 利用浙江省慢性病监测信息管理系统收集2007-2013年监测队列中糖尿病、恶性肿瘤患者及相关信息,采用累积发病率、RR值及其95%CI等指标分析2型糖尿病与恶性肿瘤间的关系。结果 2007-2013年共收集327 268例2型糖尿病患者并随访778 439人年,累计新发恶性肿瘤7 435例,恶性肿瘤发病率为955.12/10万,标化发病率为458.05/10万。相较非糖尿病人群,糖尿病患者恶性肿瘤发病风险增加(RR=1.68,95%CI:1.68~1.70),其中20~39岁组2型糖尿病患者恶性肿瘤发病风险最高(RR=4.34,95%CI:3.54~5.32);随年龄增加,风险降低,但≥60岁组发病风险仍存在关联(RR=1.21, 95%CI:1.18~1.25)。结论 2型糖尿病患者中恶性肿瘤的发病风险增加。
英文摘要:
      Objective To understand the association between type 2 diabetes and the risk of cancers. Methods Data related to type 2 diabetes mellitus (T2DM) cases and cancer cases were collected from Zhejiang Chronic Disease Surveillance Information and Management System (CDSIMS), between January 1, 2007 and December 31, 2013. Cumulative incidence and relative risk (RR) with 95% confidence interval (CI) were calculated. Results From 2007 to 2013, a total of 327 268 T2DM and 7 435 cancer cases were respectively reported and 778 439 person-years completed the followed-up program. Among the T2DM patients, incidence of cancers was 955.12 per 100 000, with standardized incidence as 458.05 per 100 000. Compared with people without T2DM, the risk of cancer incidence increased in T2DM patients (RR=1.68,95%CI:1.68-1.70). Risk appeared the highest in 20-39 year age group but decreased when the increase of age. In addition, the increased risk was still significant in T2DM patients aged ≥60 years(RR=1.21,95%CI:1.18-1.25). Conclusion Results from the study suggested that T2DM was associated with the increased risk of cancers, statistically.
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