| 韩志刚,程伟彬,钟斐,秦发举,樊莉蕊,徐慧芳.广州市1991－2013年艾滋病相关死亡影响因素分析[J].中华流行病学杂志,2015,36(12):1406-1409 |
| 广州市1991－2013年艾滋病相关死亡影响因素分析 |
| Influencing factors on AIDS-related deaths in Guangzhou 1991-2013 |
| 收稿日期:2015-04-11 出版日期:2015-12-15 |
| DOI：10.3760/cma.j.issn.0254-6450.2015.12.020 |
| 中文关键词: 艾滋病 死亡 影响因素 |
| 英文关键词: AIDS Death Influencing factor |
| 基金项目: |
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| 中文摘要: |
| 目的 分析广州市艾滋病病毒感染者和艾滋病患者(HIV/AIDS)中艾滋病相关死亡的影响因素,为采取相应的措施提供依据。方法 利用国家艾滋病综合防治信息系统中1991－2013年广州市疫情资料,使用Cox风险比例模型分析艾滋病相关死亡的影响因素。结果 广州市HIV/AIDS病例中,报病时病程阶段为AIDS(HR=2.717,95%CI:2.039～3.621)、由医疗机构诊疗发现(HR=1.516,95%CI:1.159～1.981)、未接受过CD4+T淋巴细胞检测(HR=4.866,95%CI:3.674～6.444)、符合治疗标准未治疗(HR=12.213,95%CI:8.467～17.616)、报病时年龄40岁以上的病例发生艾滋病相关死亡的风险更高。另外,不符合治疗标准而未治疗的病例发生艾滋病相关死亡的风险也高于接受抗病毒治疗的病例(HR=1.936,95%CI:1.145～3.272)。结论 及早发现HIV/AIDS病例,接受CD4+T淋巴细胞检测和抗病毒治疗可降低HIV/AIDS的死亡风险,延长生存时间。 |
| 英文摘要: |
| Objective To analyze the influencing factors on AIDS-related deaths among HIV/AIDS patients in Guangzhou, Guangdong province. Methods A retrospective cohort was formed, based on available data of HIV/AIDS patients between 1991 and 2013 in Guangzhou, that were gathered from the Chinese AIDS Prevention and Control Information System. Cox proportional hazard model was used to identify the influencing factors for AIDS-related deaths. Results Data showed that factors as: existence of full-bloom AIDS when HIV infection was diagnosed (HR=2.717, 95%CI:2.039-3.621), diagnose of AIDS was made in the hospitals(HR=1.516,95%CI:1.159-1.981), never received no CD4 count testing (HR=4.866, 95%CI: 3.674-6.444), no drugs were provided to those who met the criteria for treatment (HR=12.213,95%CI: 8.467-17.616), and patients at aged ≥40 years when HIV infection was diagnosed etc., were related to the risk for AIDS deaths. The risk of AIDS-related death was also high in those who did not meet the treatment criteria or receiving no treatment, when compared to those who had received the antiviral treatment (HR=1.936,95%CI:1.145-3.272). Conclusion Factors as: earlier diagnosis of HIV/AIDS cases, provision of CD4 count testing and antiviral treatment to more cases etc, could decrease the risk for AIDS-related deaths and improve the survival rate on HIV/AIDS cases. |
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