| 余艺文,王传鹏,韩耀风,牛建军,张一中,方亚.中国非吸烟女性肺癌危险因素的Meta分析[J].中华流行病学杂志,2016,37(2):268-272 |
| 中国非吸烟女性肺癌危险因素的Meta分析 |
| Meta-analysis on related risk factors regarding lung cancer in non-smoking Chinese women |
| 收稿日期:2015-06-19 出版日期:2016-02-18 |
| DOI：10.3760/cma.j.issn.0254-6450.2016.02.024 |
| 中文关键词: 肺癌 中国女性 危险因素 Meta分析 |
| 英文关键词: Lung cancer Chinese women Risk factors Meta-analysis |
| 基金项目:厦门市科技计划项目(3502Z20143006 |
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| 摘要点击次数: 3943 |
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| 中文摘要: |
| 目的 探讨中国非吸烟女性肺癌发病的主要危险因素,为制定肺癌防控措施提供科学依据。方法 收集国内外1995年1月至2014年11月公开发表的关于中国非吸烟女性肺癌发病危险因素的病例对照研究文献,采用Meta分析方法计算中国非吸烟女性肺癌发病危险因素的合并OR值及其95% CI,辅以敏感性分析和发表偏倚检测。结果 共纳入文献24篇,累计病例11 946例,对照12 596例。非吸烟女性肺癌发病危险因素的合并OR值及其95% CI分别为:总肺部疾病史1.89(1.57~2.27)、肺结核病史1.86(1.53~2.27)、慢性支气管炎病史1.51(1.04~2.19)、肿瘤家族史2.02(1.67~2.44)、肺癌家族史2.45(1.80~3.34)、成年期被动吸入香烟烟雾[工作场所1.47(1.28~1.69)、家庭环境1.22(1.09~1.36)]、终生被动吸入香烟烟雾1.52(1.29~1.79)、烹饪烟雾量2.21(1.27~2.96)、厨房位置1.76(1.48~2.09)、每周油炸频次2.24(1.61~3.12)。结论 中国非吸烟女性肺癌发病的主要危险因素为肺部疾病史、肿瘤家族史、被动吸烟(香烟烟雾、烹饪烟雾),其中肺癌家族史和烹饪烟雾量的合并OR值具有更为强烈的关联效应,提示遗传因素和环境因素在肺癌发病中的重要作用。 |
| 英文摘要: |
| Objective To explore the risk factors of lung cancer in non-smoking Chinese women and to provide evidence for lung cancer prevention and control.Methods Information was collected on case-control studies published in the journals, both nationally and internationally from January, 1995 to November, 2014 that reported correlations between lung cancer and risk factors.Pooled odds ratio(OR) and 95% confidence interval(CI) of risk factors on lung cancer in non-smoking Chinese women were calculated, using the Meta-analysis method, with sensitivity and publication bias tested.Results Information on 24 case-control studies was selected including 11 946 cumulative cases and 12 596 controls.Pooled ORs(95% CI) were shown as:history of lung diseases 1.89(1.57, 2.27), history of tuberculosis 1.86(1.53, 2.27), history of chronic bronchitis 1.51(1.04, 2.19), family history of cancers 2.02(1.67, 2.44), family history of lung cancers 2.45(1.80, 3.34), passive smoking(at workplace in adult period 1.47(1.28, 1.69), at home in adulthood 1.22(1.09, 1.36), in all life's time 1.52(1.29, 1.79), kitchen smog while cooking 2.21(1.27, 2.96), position of kitchen 1.76(1.48, 2.09), and frequency of deep frying per week 2.24(1.61, 3.12) etc.respectively.Conclusion Major risk factors related to lung cancer in non-smoking Chinese women would include lung diseases, family history of cancers, and passive smoking(tobacco smog and cooking smog).Particularly, the combination of family history and the degree of cooking presented stronger correlation effects, indicating that genetic and environmental factors jointly played an important role in the development of lung cancer. |
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