文章摘要
裴泓波,蒲宏全,代敏,白亚娜,昌盛,王正芳,程宁,李海燕,李娟生,胡晓斌,任晓卫.金昌队列人群胃癌疾病负担研究[J].中华流行病学杂志,2016,37(3):316-320
金昌队列人群胃癌疾病负担研究
Disease burden of gastric cancer in Jinchang cohort
收稿日期:2015-10-29  出版日期:2016-03-15
DOI:10.3760/cma.j.issn.0254-6450.2016.03.004
中文关键词: 胃癌;死亡率;潜在减寿年;潜在工作损失年;经济负担
英文关键词: Gastric cancer;Mortality rate;Potential years of life lost;Working years of potential life lost;Cohort
基金项目:国家重大公共卫生服务项目(财社2012-64);金川集团股份有限公司科学技术项目(JKZ20120013)
作者单位E-mail
裴泓波 730000 兰州大学公共卫生学院流行病与卫生统计学研究所 肿瘤防治研究中心  
蒲宏全 737100 金昌, 金川集团股份有限公司职工医院 phq@jnmc.com 
代敏 100021 北京, 中国医学科学院肿瘤医院城市癌症早诊早治项目办公室, 防癌科  
白亚娜 730000 兰州大学公共卫生学院流行病与卫生统计学研究所 肿瘤防治研究中心  
昌盛 100021 北京, 中国医学科学院肿瘤医院城市癌症早诊早治项目办公室, 防癌科  
王正芳 737100 金昌, 金川集团股份有限公司职工医院  
程宁 730000 兰州大学基础医学院 肿瘤防治研究中心  
李海燕 737100 金昌, 金川集团股份有限公司职工医院  
李娟生 730000 兰州大学公共卫生学院流行病与卫生统计学研究所 肿瘤防治研究中心  
胡晓斌 730000 兰州大学公共卫生学院流行病与卫生统计学研究所 肿瘤防治研究中心  
任晓卫 730000 兰州大学公共卫生学院流行病与卫生统计学研究所 肿瘤防治研究中心  
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中文摘要:
      目的 分析金昌队列人群中胃癌造成的疾病负担及其变化趋势。方法 应用历史队列研究方法收集金昌队列人群2001-2013年胃癌全死因资料及2001-2010年胃癌住院患者资料,应用死亡率、潜在减寿年(PYLL)、潜在工作损失年(WPYLL)、住院费用等指标评价胃癌造成的疾病负担,运用Spearman秩相关分析、平均增长速度描述疾病负担的变化趋势。结果 2001-2013年间金昌队列人群中因胃癌死亡213人、年均粗死亡率为38.30/10万,未呈现显著变化趋势。男性胃癌死亡196人、粗死亡率为56.17/10万,女性胃癌死亡17人、粗死亡率为8.21/10万,男性粗死亡率为女性的6.84倍。胃癌死亡者以50~79岁年龄段为主(176人,构成比为82.62%),<50岁年龄组胃癌死亡率呈增长趋势、年均增长速度为0.77%。因胃癌而造成的人均PYLL(APYLL)以8.43%的平均速度随年份呈下降趋势,人均WPYLL(AWPYLL)以10.46%的平均速度随年份呈下降趋势。2001-2010年该队列人群胃癌住院患者例均费用为8 102.23元,日均费用为463.45元,无明显变化趋势。结论 金昌队列人群胃癌疾病负担严重,男性尤为突出,有年轻化表现;胃癌所致PYLL及 WPYLL十余年来无明显变化趋势、而APYLL及 AWPYLL随年份呈下降趋势;住院患者直接经济负担平稳无变化。
英文摘要:
      Objective To understand the current status of disease burden caused by gastric cancer in Jinchang cohort. Methods In this historical cohort study, the data of gastric cancer deaths from 2001 to 2013 and the medical records of gastric cancer cases from 2001 to 2010 in Jinchang cohort were collected to analyze the mortality, potential years of life lost (PYLL), working PYLL (WPYLL) associated with gastric cancer, and the medical expenditure data were used to evaluate the direct economic burden. Spearman correlation analysis and the average growth rate were used to describe the change trend of disease burden of gastric cancer. Results A total of 213 gastric cancer deaths occurred in Jinchang cohort from 2001 to 2013. The average annual crude mortality rate of gastric cancer was 38.30 per 100 000 in Jinchang cohort during 2001-2013 and no obvious change was observed. The crude mortality rate in males was 6.84 times higher than that in females. Gastric cancer death mainly occurred in age group 50-79 years (82.62%), while the mortality rates was increasing among the people under 50 years with an average annual increase rate of 0.77%. The annual average PYLL(APYLL) and average WPYLL (AWPYLL) caused by gastric cancer decreased by 8.43% and 10.46%, respectively. No obvious change in medical expenditure of gastric cancer cases was observed in Jinchang Cohort during 2001-2010, and the medical expenditure and average daily cost of hospitalization were 8 102.23 Yuan, and 463.45 Yuan per capita, respectively. Conclusions The burden of disease for gastric cancer was heavy in Jinchang cohort. The PYLL and WPYLL had no change, while the APYLL and AWPYLL showed a increasing trend during the last ten years. Direct economic burden of inpatients with gastric cancer had no change.
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