文章摘要
于茂河,江国虹,斗智,李志军,郭燕,徐鹏,杨杰,徐杰.天津市浴池男男性行为人群HIV新发感染队列研究[J].中华流行病学杂志,2016,37(3):362-366
天津市浴池男男性行为人群HIV新发感染队列研究
HIV infection incidence among men who have sex with men in common bathing pool in Tianjin: a cohort study
收稿日期:2015-09-30  出版日期:2016-03-15
DOI:10.3760/cma.j.issn.0254-6450.2016.03.014
中文关键词: 同性恋浴池;男男性行为人群;HIV新发感染;队列
英文关键词: Homosexual common bathing pool;Men who have sex with men;HIV infection;Cohort
基金项目:中美艾滋病防治合作项目-天津同志浴池男男性行为者艾滋病预防综合干预试点;天津市卫生局科技基金项目(2013KZ052);天津市卫生行业重点攻关项目(12KG129)
作者单位E-mail
于茂河 300011 天津市疾病预防控制中心  
江国虹 300011 天津市疾病预防控制中心  
斗智 102206 北京, 中国疾病预防控制中心性病艾滋病预防控制中心  
李志军 100600 北京, 美国疾病预防控制中心全球艾滋病项目中国办事处  
郭燕 300011 天津市疾病预防控制中心  
徐鹏 300011 天津市疾病预防控制中心  
杨杰 300121 天津, 深蓝公共卫生咨询服务中心  
徐杰 102206 北京, 中国疾病预防控制中心性病艾滋病预防控制中心 xujie@chinaaids.cn 
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中文摘要:
      目的 通过队列研究分析天津市浴池MSM人群HIV新发感染状况及影响因素,为在MSM人群中开展HIV感染的预防和干预提供依据。方法 以经常光顾天津市某同性恋浴池、曾发生过男男性行为的MSM为研究对象,于2011年4月至2013年9月采用同伴推动法招募研究对象,建立MSM人群开放性队列,完成HIV检测和基线调查,并进行跟踪随访检测。调查内容包括人口学特征、艾滋病相关知识知晓情况、艾滋病相关行为情况等信息。以随访过程中"HIV阳转"为结局因变量,同时,将从研究对象进入队列到出现HIV阳转的时间为时间因变量,应用Cox比例风险模型进行浴池型MSM人群HIV新发感染影响因素的分析。结果 调查期间符合条件的研究对象733例,共新发HIV感染59例,队列随访累积观察时间为7 384.9人月,HIV新发感染率为9.59/100人年(95%CI:7.3/100人年~11.92/100人年)。多因素 Cox 回归分析显示,天津市浴池型MSM人群的危险因素包括:年龄较低者相比较年长者艾滋病知识知晓率低者(HR=1.82,95%CI:1.03~2.66)相比较知晓率高者,多性伴者(HR=1.74,95%CI:1.26~2.58)相比较固定性伴者,正在感染梅毒者(HR=2.36,95%CI:1.31~3.27),均易发生HIV的新发感染。结论 同性恋浴池MSM人群中年龄较低、艾滋病知识知晓率低、多性伴、梅毒感染为该人群HIV新发感染的危险因素,应针对危险因素加强浴池型MSM人群HIV新发感染的监测和干预。
英文摘要:
      Objective To investigate incidence of HIV infection and identify associated risk factors among men who have sex with men (MSM) in common bathing pools in Tianjin. Methods A prospective cohort study was conducted among the MSM recruited in a common bathing pool in Tianjin from 2011 to 2013. A total of 733 MSM were surveyed to obtain the information about their sociodemographic characteristics, HIV-related knowledge awareness and sexual behaviors, and subsequent follow-up surveys were carried out every four months. Cox regression analysis was conducted to identify the risk factors for HIV infection. Results A total of 59 HIV infection cases were found in the 2.5-years follow-up survey. The cumulative follow-up time was 7 384.9 person- months. The incidence rate of HIV infection was 9.59/100 person-year. The multivariate Cox regression analysis showed that young age, low score of HIV/AIDS knowledge awareness (HR=1.82, 95%CI:1.03-2.66), having two and more sexual partners during past 6 months (HR=1.74, 95%CI: 1.26-2.58) and syphilis (HR=2.36, 95%CI:1.31-3.27) were significantly associated with HIV infection in this MSM cohort. Conclusions Low score of HIV/AIDS knowledge awareness, young age, having two and more sexual partners during past 6 months and syphilis were the risk factors for HIV infection in MSM in common bathing pools. It is necessary to strengthen the HIV surveillance and intervention in this population.
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