| 高培,王怀,陈维欣,孙燕妮,张卫,庞星火,贺雄,吴疆.北京市自然人群乙型肝炎血清流行病学研究[J].中华流行病学杂志,2016,37(5):658-662 |
| 北京市自然人群乙型肝炎血清流行病学研究 |
| A sero-epidemiological study of hepatitis B among general population in Beijing |
| 收稿日期:2015-11-19 出版日期:2016-05-13 |
| DOI：10.3760/cma.j.issn.0254-6450.2016.05.014 |
| 中文关键词: 乙型肝炎 血清流行病学研究 阳性率 自然人群 |
| 英文关键词: Hepatitis B Sero-epidemiologic study Prevalence rate General population |
| 基金项目:国家科技重大专项(2012ZX10004904,2012ZX10002001003003);北京市科学技术委员会基金(D121100003912001) |
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| 中文摘要: |
| 目的 了解北京市自然人群乙型肝炎血清学感染状况,分析评价乙型肝炎综合防治效果。方法 2013年8月至2014年2月在北京市范围内按照多阶段整群随机抽样方法调查1岁以上各年龄组自然人群,估算样本量5200人,调查内容包括采集静脉血检测HBV五项血清学指标,问卷调查乙型肝炎疫苗接种情况及相关危险因素。结果 实际调查6705人。乙型肝炎HBsAg、抗-HBs、抗-HBc阳性率以及HBV总感染率分别为2.74%、44.72%、26.91%和26.95%,年龄标化率分别为2.73%、44.83%、26.84%、26.87%。北京市自然人群HBsAg阳性率已经降至2.73%,<5岁儿童HBsAg阳性率继续维持<1%,<25岁人群HBsAg阳性率<1%。结论 北京市乙型肝炎综合防治策略效果显著,应该继续加强成年人乙型肝炎疫苗免疫接种工作。 |
| 英文摘要: |
| Objective To understand the sero-prevalence of hepatitis B in general population in Beijing and provide evidence for the prevention and control of hepatitis B. Methods A serological survey was conducted in general population aged >1 year selected through multistage randomized cluster sampling in Beijing from August 2013 to February 2014. The estimated sample size was 5 200.Venous blood samples were collected from them to detect five hepatitis B serological indicators. The information about the hepatitis B immunization history and risk factors of the study subjects were collected through a questionnaire survey. Results A total of 6 705 people were surveyed. The sero-positive rates of HBsAg, anti-HBs, anti-HBc and total HBV infection rate were 2.74%, 44.72%, 26.91% and 26.95% respectively. The age standardized rates were 2.73%, 44.83%, 26.84% and 26.87%respectively. As for the general population, in Beijing since the prevalence rate of hepatitis B surface antigen has decreased to 2.73%, <1% in children aged less than 5 years old, <1% in people aged less than 25 years old. Conclusion The integrated prevention and control strategy of hepatitis B had a significant effect in Beijing. We should continue to strengthen the work of adult hepatitis B vaccination. |
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