| 李宁,王晓卫,聂玉刚,马彦民,杨文杰,樊盼英,孙定勇,朱谦.河南省2011-2015年艾滋病哨点吸毒人群HCV感染状况及影响因素分析[J].中华流行病学杂志,2016,37(6):821-825 |
| 河南省2011-2015年艾滋病哨点吸毒人群HCV感染状况及影响因素分析 |
| HCV infection status and related risk factors in drug users under HIV sentinel surveillance in Henan province, 2011-2015 |
| 收稿日期:2016-01-07 出版日期:2016-06-14 |
| DOI：10.3760/cma.j.issn.0254-6450.2016.06.016 |
| 中文关键词: 丙型肝炎病毒 抗体阳性率 影响因素 |
| 英文关键词: Hepatitis C Antibody positive rate Influencing factors |
| 基金项目:国家科技重大专项(2012ZX10004905) |
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| 中文摘要: |
| 目的 分析河南省艾滋病哨点吸毒人群HCV感染情况及影响因素,为制定防治策略提供依据。方法 2011-2015年,在哨点监测期(4-6月)内以重复横断面调查的方法对河南省吸毒人群进行问卷调查和血清学检测,分析该人群HCV感染情况及影响因素。结果 2011-2015年,河南省吸毒人群HCV感染率从2011年的3.70%上升到2015年的6.54%(趋势χ2=25.93,P<0.01)。多因素分析结果显示:年龄较高(OR=1.23,95%CI:1.13~1.35,P=0.00)、外省户籍(OR=3.45,95%CI:2.59~4.60,P=0.00)、传统毒品和混合毒品使用者(OR=1.46,95%CI:1.10~1.93,P=0.01;OR=1.82,95%CI:1.18~2.81,P=0.01)、有注射毒品史(OR=2.88, 95%CI:2.45~3.39,P=0.00)、最近一年有商业性行为史(OR=1.44,95%CI:1.20~1.72,P=0.00)、来自强制戒毒所和美沙酮门诊的吸毒人员(OR=1.79,95%CI:1.28~2.50,P=0.00;OR=1.74, 95%CI:1.17~2.58,P=0.01)是感染HCV的危险因素。结论 河南省吸毒人群HCV抗体阳性率较高,且呈上升趋势,应加强对吸毒人群的监管,制定有效干预措施,控制HCV的传播。 |
| 英文摘要: |
| Objective To understand the hepatitis C virus infection status and related risk factors in drug users in Henan province during 2011-2015 and provide scientific evidence for the development of HCV infection prevention and control measures. Methods Cross-sectional questionnaire surveys were conducted among the drug users and blood samples were taken from them for HCV antibody detection during HIV sentinel surveillance period in Henan province from April to June during 2011-2015. Results The HCV infection rate in drug users increased from 3.70% in 2011 to 6.54% in 2015 (trend χ2=25.93, P<0.01). Multivariate analysis indicated that HCV infection related risk factors included age older (OR=1.23, 95%CI:1.13-1.35, P=0.00), place of domicile (OR=3.45, 95%CI:2.59-4.60, P=0.00), traditional drug user or mixed drug user (OR=1.46, 95%CI:1.10-1.93, P=0.01; OR=1.82, 95%CI:1.18-2.81, P=0.01), injecting drug user (OR=2.88, 95%CI:2.45-3.39, P=0.00), commercial sex behavior in recent one year (OR=1.44, 95%CI:1.20-1.72, P=0.00) and drug user in compulsory drug rehabilitation or those receiving methadone maintenance treatment (OR=1.79, 95%CI:1.28-2.50, P=0.00; OR=1.74, 95%CI:1.17-2.58, P=0.01). Conclusion The HCV infection rate in drug users was higher in Henan and increased rapidly with years. In order to control HCV spread, it is necessary to strengthen the management of drug users and take effective intervention measures. |
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