文章摘要
徐秋萍,何斐,刘志强,熊为旻,林剑波,蔡琳.性别对非小细胞肺癌预后的影响分析[J].中华流行病学杂志,2017,38(2):244-247
性别对非小细胞肺癌预后的影响分析
Effect of gender on the prognosis of patients with non-small cell lung cancer
收稿日期:2016-07-13  出版日期:2017-02-17
DOI:10.3760/cma.j.issn.0254-6450.2017.02.022
中文关键词: 非小细胞肺癌;预后;性别
英文关键词: Non-small cell lung cancer;Prognosis;Sex
基金项目:国家自然科学基金(81172766,81402738);福建省环保科技计划项目(2015R012);福建省自然科学基金面上项目(2016J01355);福建省卫生计划生育委员会联合攻关项目(WKJ-FJ-18)
作者单位E-mail
徐秋萍 350108 福州, 福建医科大学公共卫生学院流行病与卫生统计学系  
何斐 350108 福州, 福建医科大学公共卫生学院流行病与卫生统计学系  
刘志强 350108 福州, 福建医科大学公共卫生学院流行病与卫生统计学系  
熊为旻 350108 福州, 福建医科大学公共卫生学院流行病与卫生统计学系  
林剑波 350108 福州, 福建医科大学附属第一医院胸外科  
蔡琳 350108 福州, 福建医科大学公共卫生学院流行病与卫生统计学系 cailin_cn@hotmail.com 
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中文摘要:
      目的 分析性别对非小细胞肺癌(NSCLC)预后的影响。方法 回顾性分析1 195例NSCLC患者的调查资料,应用χ2检验、Kaplan-Meier、log-rank检验和Cox回归模型进行预后分析。结果 本组患者男性中位生存期为22.71个月,女性为31.64个月,差异有统计学意义(P<0.01)。分层分析显示在年龄、病理类型、临床分期、肿瘤最大径、胸腔积液以及是否手术等水平上,女性的生存期均好于男性。Cox回归分析发现吸烟、临床分期、首诊有无转移及有无手术与NSCLC预后密切相关,而性别不是NSCLC患者预后的独立影响因素。调整潜在的混杂因素后进一步分析性别与NSCLC预后的关联,发现吸烟是影响性别与NSCLC预后关系的最主要混杂因素。结论 性别非NSCLC患者预后的独立影响因素,女性NSCLC患者的预后优势主要是由于吸烟状况在性别中分布不均所致。
英文摘要:
      Objective To analyze the effect of gender on the prognosis of patients with non-small cell lung cancer (NSCLC). Methods Data of 1 195 patients with NSCLC were analyzed by Chi-square, Kaplan-Meier, log-rank tests and Cox regression models. Results Women had a longer survival than men (median overall survival 31.64 versus 22.71 months, P<0.01) in the participants of this study. Differences seen in overall survival remained the similar, after stratified by age, pathologic types, clinical stage, sizes, pleural effusion and surgery of the patients, respectively. Data from the multivariate analysis revealed that factors as smoking, clinical stage, metastatic when diagnosis was made and surgery, but not gender, were independent prognostic factors for patients with NSCLC. After adjustment for potential confounders, we found that smoking was a major confounding factor, affecting the relationship between gender and prognosis of NSCLC. Conclusion Gender did not seem an independent prognostic factor for NSCLC patients while the survival advantages of females might be attributed to the lower prevalence of smoking in this population.
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