| 陈琦,邢学森,吴杨,廖巧红,刘公平,蒋晓清,官旭华.湖北省2009－2015年手足口病流行病学和病原学分析[J].中华流行病学杂志,2017,38(4):441-445 |
| 湖北省2009－2015年手足口病流行病学和病原学分析 |
| Hand, foot and mouth disease in Hubei province, 2009-2015: an epidemiological and etiological study |
| 收稿日期:2016-12-25 出版日期:2017-04-27 |
| DOI：10.3760/cma.j.issn.0254-6450.2017.04.006 |
| 中文关键词: 手足口病 流行特征 病原学 |
| 英文关键词: Hand, foot and mouth disease Epidemiological characteristics Pathogens spectrum |
| 基金项目: |
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| 中文摘要: |
| 目的 描述2009－2015年湖北省手足口病的分年龄组、轻症和重症死亡病例的流行病学和病原学特征，为制定手足口病防控策略提供依据。方法 利用2009－2015年传染病报告信息管理系统中报告的湖北省手足口病例个案信息和湖北省各级CDC病原学监测的信息；通过对病例年龄、病例类型、临床诊断病例和实验室确诊及不同血清型分层分析。结果 2009－2015年湖北省累计报告手足口病495 783例，年均发病率为1 231.0/100万。手足口病高发的年龄段为0.5～5岁，重症和死亡病例发生风险的高发年龄段为6～11月龄。轻症病例2009－2015年的优势病原每年依次是EV71、Cox A16、Cox A16、Cox A16、EV71、Cox A16和其他肠道病毒。发病高峰出现于每年的4－6月和11－12月，偶数年比奇数年发病峰值高。结论 2009－2015年湖北省手足口病重点干预人群是0.5～5岁婴幼儿，尤其是发生重症死亡风险高的6～11月龄婴儿。加强对重点人群的监测，有效防控手足口病，减少重症和死亡。 |
| 英文摘要: |
| Objective To clarify the age patterns and types of differences so as to provide reference on prevention and interventions of hand, foot and mouth disease (HFMD) cases, in Hubei province. Methods We collected the HFMD case information of Hubei province from the Chinese National Notifiable Infectious Disease Reporting System in 2009-2015 while the information on pathogens from the laboratory monitoring system of Center for Disease Control and Prevention at all levels in Hubei province. All the data were stratified by age, disease severity, laboratory confirmation status, and serotypes of enterovirus. Results There were 495 783 reported HFMD cases from 2009 to 2015, in Hubei province, of which 1 045 were severe with 99 fatal. The annual notification rate was 1 231.0/106. HFMD cases were concentrated mainly in 0.5-5 year olds, with highest severity and mortality seen in 6-11 month-olds. The predominated pathogen in mild laboratory-confirmed cases each year, in order during 2009-2015 as: EV71, Cox A16, Cox A16, Cox A16, EV71, Cox A16 and other EV. HFMD showed semiannual peaks in April-June, November-December, and with more cases in the even years than in the odd years. Conclusions Children aged 0.5 to 5 years with 6 to 11 month-olds in particular, were the focused groups of attention in Hubei province. Our findings provided evidence for the improvement on monitoring program. Targeted intervention approaches should be strengthened to reduce the mortality and morbidity of HFMD in the province. |
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