文章摘要
苏健,陶然,周金意,杨婕,覃玉,胡一河,陆艳,金建荣,卞铮,郭彧,陈铮鸣,李立明,武鸣.成年人睡眠状况与糖尿病患病关系的研究[J].中华流行病学杂志,2017,38(5):597-601
成年人睡眠状况与糖尿病患病关系的研究
Relationship between sleep status and the risk of diabetes in adults
收稿日期:2016-10-12  出版日期:2017-05-18
DOI:10.3760/cma.j.issn.0254-6450.2017.05.008
中文关键词: 糖尿病;睡眠状况;风险
英文关键词: Diabetes;Sleep status;Risk
基金项目:国家自然科学基金(81390541,81390544);香港 Kadooric Charitable Foundation;英国 Wellcome Trust(088158/Z/09/Z);江苏省医学领军人才和创新团队项目(K201105);江苏省医学重点人才项目(RC2011192)
作者单位E-mail
苏健 210009 南京, 江苏省疾病预防控制中心  
陶然 210009 南京, 江苏省疾病预防控制中心
850000 拉萨市疾病预防控制中心 
 
周金意 210009 南京, 江苏省疾病预防控制中心  
杨婕 210009 南京, 江苏省疾病预防控制中心  
覃玉 210009 南京, 江苏省疾病预防控制中心  
胡一河 215004 苏州市疾病预防控制中心  
陆艳 215004 苏州市疾病预防控制中心  
金建荣 215100 苏州市吴中区疾病预防控制中心  
卞铮 102308 北京, 中国医学科学院  
郭彧 102308 北京, 中国医学科学院  
陈铮鸣 英国牛津大学临床与流行病学研究中心  
李立明 102308 北京, 中国医学科学院
100191 北京大学公共卫生学院 
lmlee@pumc.edu.cn 
武鸣 210009 南京, 江苏省疾病预防控制中心 jswuming@vip.sina.com 
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中文摘要:
      目的 探讨成年人睡眠状况与糖尿病患病关系。方法 利用“中国慢性病前瞻性研究”苏州市项目点53 260名30~79岁常住居民基线调查数据,通过多因素logistic回归模型分析睡眠状况与糖尿病患病关系。结果 调查人群糖尿病患病率为5.3%,入睡困难、容易早醒和经常打鼾的比例分别为7.2%、10.0%和29.5%,22.6%的调查对象报告睡眠时间≤6 h。经多因素模型调整后,入睡困难(男性:OR=1.63,95%CI:1.30~2.05;女性:OR=1.48,95%CI:1.27~1.73)、容易早醒(男性:OR=1.37,95%CI:1.12~1.68;女性:OR=1.31,95%CI:1.14~1.51)和经常打鼾(男性:OR=1.16,95%CI:1.00~1.34;女性:OR=1.39,95%CI:1.23~1.57)均与糖尿病罹患风险存在关联。女性服用助眠药物与糖尿病的患病相关(OR=1.42,95%CI:1.06~1.92)。与睡眠时间8 h相比,睡眠时间不足(≤6 h)与男女性糖尿病患病均存在统计学关联,OR值分别为1.37(95%CI:1.17~1.60)和1.24(95%CI:1.08~1.41),睡眠时间过长(≥9 h)与糖尿病未见统计学关联。结论 睡眠问题(入睡困难、容易早醒、药物助眠、经常打鼾和睡眠时间不足)与糖尿病患病风险密切相关,睡眠时间过长与糖尿病患病未见统计学关联。
英文摘要:
      Objective To explore the relationship between sleep status and the risk of diabetes in adults. Methods The baseline data of 53 260 subjects who were aged 30-79 years and had been enrolled into China Kadoorie Biobank (CKB) study from Suzhou, Jiangsu province were analyzed. Multiple logistic regression models were used to investigate the association between sleep status and diabetes after adjusting for potential confounders. Results Among 53 260 subjects, 5.3% had diabetes. The proportions of difficultly falling asleep, early morning arousal and snoring frequently was 7.2%, 10.0% and 29.5%, respectively. There were 22.6% of subjects reporting sleep duration ≤6 hours. After controlling for possible confounders, the subjects with difficulty falling sleep (OR=1.63 for male, 95%CI: 1.30-2.05; OR=1.48 for female, 95%CI: 1.27-1.73), early morning arousal (OR=1.37 for male, 95%CI: 1.12-1.68; OR=1.31 for female, 95%CI: 1.14-1.51) or snoring frequently (OR=1.16 for male, 95%CI: 1.00-1.34; OR=1.39 for female, 95%CI: 1.23-1.57) had a higher risk of diabetes. Using hypnotics regularly was associated with the risk of diabetes in females (OR=1.42, 95%CI: 1.06-1.92). Compared with 8 hours sleep duration daily, shorter sleep duration (≤6 hours) was associated with risk of diabetes in both males (OR=1.37, 95%CI: 1.17-1.60) and females (OR=1.24, 95%CI: 1.08-1.41). No statistical significant association was found between longer sleep duration (≥9 hours) and the risk of diabetes. Conclusion Sleep problems, including difficulty falling asleep, early morning arousal, snoring frequently and shorter sleep duration, were associated with the risk of diabetes, but no statistical significant association was observed between longer sleep duration and the risk of diabetes.
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