| 徐嘉悦,牟雨婵,马原林,张菊英.成都市男男性行为人群艾滋病暴露前预防用药服药依从性分析[J].中华流行病学杂志,2017,38(5):643-645 |
| 成都市男男性行为人群艾滋病暴露前预防用药服药依从性分析 |
| Compliancy of pre-exposure prophylaxis for HIV infection in men who have sex with men in Chengdu |
| 收稿日期:2016-10-24 出版日期:2017-05-18 |
| DOI：10.3760/cma.j.issn.0254-6450.2017.05.017 |
| 中文关键词: 男男性行为者 艾滋病 暴露前预防用药 依从性 |
| 英文关键词: Men who have sex with men AIDS Pre-exposure prophylaxis Compliancy |
| 基金项目:国家科技重大专项（2012ZX10001007-007） |
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| 中文摘要: |
| 目的 了解成都市MSM人群在艾滋病暴露前预防用药（PrEP）的依从性及影响因素。方法 按照随机、开放、多中心平行对照临床干预研究，于2013年7月1日至2015年9月30日按照样本量估算，采用滚雪球法招募合格的研究对象为HIV高感染风险且HIV检测结果阴性的MSM，共328人，随机化分配为每日用药组、高危行为前后用药组和空白对照组，每 3个月进行临床随访和问卷调查。评价每日用药组、高危行为前后用药组的服药依从性，并用logistic回归模型探讨PrEP服药依从性的影响因素。结果 共分析141名研究对象，41.8%（59/141）PrEP服药依从性好，每日用药组和高危行为前后服药组的PrEP服药依从性分别为69.0%（49/71）、14.3%（10/70），差异有统计学意义（χ2=45.29，P<0.001）。多因素logistic分析结果显示，用药方式是PrEP服药依从性的影响因素，相比于每日用药组，高危行为前后用药组的服药依从性相较差（OR=0.07，95%CI：0.03~0.16）。结论 MSM人群PrEP服药依从性总体不够理想，用药方式是PrEP服药依从性的主要影响因素。 |
| 英文摘要: |
| Objective To evaluate the compliancy of HIV pre-exposure prophylaxis (PrEP) in men who have sex with men (MSM) in Chengdu, Sichuan province, and explore the influencing factors. Methods From 1 July 2013 to 30 September 2015, a random, open, multi-center and parallel control intervention study was conducted in 328 MSM enrolled by non-probability sampling in Chengdu. The MSM were divided into 3 groups randomly, i.e. daily group, intermittent group (before and after exposure) and control group. Clinical follow-up and questionnaire survey were carried out every 3 months. Their PrEP compliances were evaluated respectively and multivariate logistic regression analysis was conducted to identify the related factors. Results A total of 141 MSM were surveyed, in whom 59(41.8%) had good PrEP compliancy. The PrEP compliancy rate was 69.0% in daily group, higher than that in intermittent group (14.3%), the difference had significance (χ2=45.29,P<0.001). Multivariate logistic analysis indicated that type of PrEP was the influencing factors of PrEP compliancy. Compared with daily group, the intermittent group had worse PrEP compliancy (OR=0.07, 95%CI: 0.03-0.16). Conclusion The PrEP compliance of the MSM in this study was poor, the compliancy would be influenced by the type of PrEP. |
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