文章摘要
陈敏,王继宝,邢辉,马艳玲,杨锦,陈会超,姚仕堂,罗红兵,段星,王译葵,段松,贾曼红.云南省德宏傣族景颇族自治州2015年HIV-1耐药传播警戒线调查[J].中华流行病学杂志,2017,38(7):959-962
云南省德宏傣族景颇族自治州2015年HIV-1耐药传播警戒线调查
HIV-1 drug resistance transmission threshold survey in Dehong prefecture of Yunnan province, 2015
收稿日期:2016-11-08  出版日期:2017-07-15
DOI:10.3760/cma.j.issn.0254-6450.2017.07.022
中文关键词: 人类免疫缺陷病毒;基因型;耐药警戒线调查;抗病毒治疗
英文关键词: HIV;Genotype;Drug resistance threshold survey;Antiretroviral therapy
基金项目:国家科技重大专项(2012ZX10001-002)
作者单位E-mail
陈敏 650022 昆明, 云南省疾病预防控制中心性病艾滋病防制所  
王继宝 678400 芒市, 云南省德宏州疾病预防控制中心艾滋病性病防治科  
邢辉 102206 北京, 中国疾病预防控制中心性病艾滋病预防控制中心病毒及免疫研究室  
马艳玲 650022 昆明, 云南省疾病预防控制中心性病艾滋病防制所  
杨锦 678400 芒市, 云南省德宏州疾病预防控制中心艾滋病性病防治科  
陈会超 650022 昆明, 云南省疾病预防控制中心性病艾滋病防制所  
姚仕堂 678400 芒市, 云南省德宏州疾病预防控制中心艾滋病性病防治科  
罗红兵 650022 昆明, 云南省疾病预防控制中心性病艾滋病防制所  
段星 678400 芒市, 云南省德宏州疾病预防控制中心艾滋病性病防治科  
王译葵 678400 芒市, 云南省德宏州疾病预防控制中心艾滋病性病防治科  
段松 678400 芒市, 云南省德宏州疾病预防控制中心艾滋病性病防治科 dhduansong@sina.com 
贾曼红 650022 昆明, 云南省疾病预防控制中心性病艾滋病防制所 jiamanhong@hotmail.com 
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中文摘要:
      目的 了解2015年云南省德宏傣族景颇族自治州(德宏州)未接受抗病毒治疗的HIV感染者的耐药株传播水平。方法 2015年1-7月在德宏州收集72份新报告的16~25岁HIV-1感染者的血浆样品,进行HIV-1基因型耐药检测和耐药株传播水平分析。结果 48份完成了基因型及耐药鉴定,其中中国籍占31.2%(15/48),缅甸籍占68.8%(33/48)。通过进化分析对pol区进行分型,主要的基因型包括URF(52.08%,25/48)、CRF01_AE(16.67%,8/48)、CRF07_BC(10.42%,5/48)、B亚型(6.25%,3/48)、C亚型(6.25%,3/48)、CRF57_BC(6.25%,3/48)和CRF08_BC(2.08%,1/48)。在4个序列中分别检测到1个针对非核苷类反转录酶抑制剂的耐药突变位点(K103N)和2个针对核苷类反转录酶抑制剂的耐药突变位点(T69D和T215I),按照耐药警戒线的统计方法估算耐药株流行率为5%~15%。结论 2015年德宏州16~25岁新报告的HIV-1感染人群中外籍比例较高,HIV-1基因型复杂,HIV-1传播性耐药达中度水平。
英文摘要:
      Objective To study the HIV-1 drug resistance transmission level in HIV infected persons receiving no antiviral therapy in Dehong prefecture of Yunnan province in 2015. Methods A total of 72 plasma samples were collected from recently reported HIV-infected persons aged 16-25 years in Dehong from January to July 2015 for drug resistance gene detection. Results Forty eight samples were successfully sequenced and analyzed. Among them, 31.2% (15/48) were from Chinese, and 68.8% (33/48) were from Burmese. Based on pol sequences, HIV genotypes included URF (52.08%, 25/48), CRF01_AE (16.67%, 8/48), RF07_BC (10.42%, 5/48), subtype B (6.25%, 3/48), subtype C (6.25%, 3/48), CRF57_BC (6.25%, 3/48) and CRF08_BC (2.08%, 1/48). One drug resistant mutation site to non-nucleoside analog reverse transcriptase inhibitor (NNRTI) and two drug resistant mutation site to nucleoside analog reverse transcriptase inhibitor (NRTI) were detected in four sequences. Based on the statistical method of HIV drug resistance threshold survey, the prevalence of HIV-1 drug resistant strain was 5%-15%. Conclusions The proportion of Burmese among newly reported HIV-infected individuals aged 16-25 years in Dehong in 2015 was higher. HIV-1 genetic diversity was found in Dehong. The prevalence of HIV-1 drug resistant strain had reached a moderate level in Dehong.
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