| 郑维晖,龚巍巍,陆凤,俞敏.甲状腺癌相关基因突变和表观遗传学研究进展[J].中华流行病学杂志,2017,38(11):1579-1583 |
| 甲状腺癌相关基因突变和表观遗传学研究进展 |
| Progress in research of thyroid carcinoma related gene mutation and epigenetics |
| 收稿日期:2017-03-27 出版日期:2017-11-11 |
| DOI：10.3760/cma.j.issn.0254-6450.2017.11.028 |
| 中文关键词: 甲状腺癌 基因突变 表观遗传学 |
| 英文关键词: Thyroid carcinoma Gene mutation Epigenetics |
| 基金项目:国家卫生和计划生育委员会科研基金-浙江省医药卫生重大科技计划（WKJ-ZJ-1506） |
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| 中文摘要: |
| 甲状腺癌的分子发病机制也是一个多基因参与、多个步骤的癌变过程。随着分子生物学诊断技术的不断发展，在甲状腺癌组织中发现多种相关基因突变和表观遗传学现象。了解甲状腺癌的最新基因突变和表观遗传学研究进展，有助于甲状腺癌的早期诊断、防治和靶向药物研发。 |
| 英文摘要: |
| Thyroid cancer is one of the most common endocrine malignant tumors, and its molecular pathogenesis is also a process of multiple genes involved in many steps of carcinogenesis. With the development of molecular biology technology, a variety of related gene mutations and epigenetic phenomena have been found in thyroid cancer tissues. It is helpful to understand the latest progress in the research of the gene mutation and epigenetics of thyroid cancer for its early diagnosis, prevention and the development of targeted drugs. |
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