| 陈星,鲍慧惠,吴皖珂,严双琴,盛杰,许媛媛,顾春丽,黄锟,曹慧,苏普玉,陶芳标,郝加虎.孕期双酚A暴露对学龄前儿童情绪和行为问题的影响[J].中华流行病学杂志,2018,39(2):188-193 |
| 孕期双酚A暴露对学龄前儿童情绪和行为问题的影响 |
| Exposure to bisphenol A during maternal pregnancy and the emotional and behavioral impact on their preschool children |
| 收稿日期:2017-06-06 出版日期:2018-02-10 |
| DOI：10.3760/cma.j.issn.0254-6450.2018.02.010 |
| 中文关键词: 双酚A 妊娠 儿童行为 |
| 英文关键词: Bisphenol A Pregnancy Child behavior |
| 基金项目:国家自然科学基金（81573164、81573163、81072310） |
| 作者 | 单位 | E-mail | | 陈星 | 230032 合肥, 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系 | | | 鲍慧惠 | 230032 合肥, 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系 | | | 吴皖珂 | 230032 合肥, 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系 | | | 严双琴 | 243000 安徽省马鞍山市妇幼保健院 | | | 盛杰 | 230032 合肥, 人口健康与优生安徽省重点实验室 | | | 许媛媛 | 230032 合肥, 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系
230032 合肥, 人口健康与优生安徽省重点实验室 | | | 顾春丽 | 243000 安徽省马鞍山市妇幼保健院 | | | 黄锟 | 230032 合肥, 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系
230032 合肥, 人口健康与优生安徽省重点实验室 | | | 曹慧 | 243000 安徽省马鞍山市妇幼保健院 | | | 苏普玉 | 230032 合肥, 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系
230032 合肥, 人口健康与优生安徽省重点实验室 | | | 陶芳标 | 230032 合肥, 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系
230032 合肥, 人口健康与优生安徽省重点实验室 | | | 郝加虎 | 230032 合肥, 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系
230032 合肥, 人口健康与优生安徽省重点实验室 | jia7128@126.com |
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| 中文摘要: |
| 目的 探讨孕期双酚A（BPA）暴露对学龄前儿童情绪和行为问题的远期影响效应。方法 研究样本源于中国安徽出生队列研究（China-Anhui Birth Cohort Study）的前瞻性随访人群。采用课题组编制的调查表收集孕妇和儿童的基本信息，运用固相萃取-同位素内标-高效液相色谱串联质谱法检测母亲孕期血清中游离的BPA含量。应用长处和困难问卷评估学龄前儿童的情绪和行为问题，最终纳入1 713对母子。运用多分类logistic回归模型分析孕期BPA暴露与学龄前儿童情绪和行为问题的病因关联。结果 1 713名学龄前儿童中，情绪症状异常检出率为6.48%，品行问题异常检出率为8.11%，多动/注意缺陷异常检出率为8.35%，同伴交往异常检出率为2.86%，亲社会行为问题异常检出率为11.38%，困难总分异常检出率为7.94%。按血清游离BPA浓度（ng/ml）三分位数法将研究对象分为低暴露组（≤ 0.120）、中暴露组（0.120OR=1.876，95% CI：1.161~3.029），且在男童中表现更明显（OR=2.291，95% CI：1.126~4.661）。结论 母亲孕期高水平BPA暴露可能增加学龄前儿童品行问题异常的发生风险，且在男童中表现得更为明显。 |
| 英文摘要: |
| Objective To explore the long-term effects of maternal pregnancy bisphenol A (BPA) exposure on emotional and behavioral problems appeared in their preschool children. Methods The study sample was a subset of the China-Anhui Birth Cohort Study (C-ABCS). A unified questionnaire was used to collect basic information on both pregnant women and their children. Free BPA concentration in maternal serum was determined by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The parent-report version of the Strengths and Difficulties Questionnaire (SDQ) was used to estimate the emotional and behavioral problems in preschool children. A total of 1 713 pairs of mothers and children were included in this study. Association between BPA exposure during pregnancy and the emotional and behavioral problems in preschool children was evaluated with multinomial logistic regression model. Results Prevalence rates in 1 713 preschool children appeared as:6.48% of emotional problems, 8.11% for conduct problems, 8.35% for hyperactivity/inattention, 2.86% for peer problems, 11.38% for prosocial behaviors and 7.94% for total difficulties. Subjects were divided according to the degrees of exposure and the results showed as:low exposure group (≤ 0.120 ng/ml), medium exposure group (0.120 < BPA < 0.400 ng/ml) and high exposure group (≥ 0.400 ng/ml) according to the serum BPA concentration in tertile. Results from the multivariate logistic regression analysis showed that high level of maternal BPA exposure appeared a risk factor on children's abnormal conducts (OR=1.876, 95% CI:1.161-3.029), more obvious in boys (OR=2.291, 95% CI:1.126-4.661). Conclusion Maternal exposure to high level of BPA during pregnancy might increase the detrimental effects of abnormal conducts in their preschool children, more obviously seen in boys. |
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