文章摘要
张冬冬,刘雪娇,王炳源,任永成,赵阳,刘飞燕,刘徳臣,程诚,陈序,刘磊磊,周琼桂,徐琦焕,熊一涵,刘佳立,游子扬,张明,胡东生.我国成年人群年龄对体质指数与高血压发病风险的修饰效应[J].中华流行病学杂志,2018,39(6):765-769
我国成年人群年龄对体质指数与高血压发病风险的修饰效应
Age-related modification effect on the association between body mass index and the risk of hypertension: A Cohort Study on Chinese people living in the rural areas
投稿时间:2017-10-12  
DOI:10.3760/cma.j.issn.0254-6450.2018.06.014
中文关键词: 体质指数;高血压;年龄;修饰效应;队列研究
英文关键词: Body mass index;Hypertension;Age;Modification;Cohort
基金项目:国家自然科学基金(81373074,81402752,81673260)
作者单位E-mail
张冬冬 450001 郑州大学公共卫生学院流行病与卫生统计学系  
刘雪娇 450001 郑州大学公共卫生学院流行病与卫生统计学系  
王炳源 450001 郑州大学公共卫生学院流行病与卫生统计学系  
任永成 450001 郑州大学公共卫生学院流行病与卫生统计学系  
赵阳 450001 郑州大学公共卫生学院流行病与卫生统计学系  
刘飞燕 518060 深圳大学医学部预防医学系  
刘徳臣 450001 郑州大学公共卫生学院流行病与卫生统计学系  
程诚 450001 郑州大学公共卫生学院流行病与卫生统计学系  
陈序 450001 郑州大学公共卫生学院流行病与卫生统计学系  
刘磊磊 450001 郑州大学公共卫生学院流行病与卫生统计学系  
周琼桂 518060 深圳大学医学部预防医学系  
徐琦焕 518060 深圳大学医学部临床医学系  
熊一涵 518060 深圳大学医学部临床医学系  
刘佳立 518060 深圳大学医学部临床医学系  
游子扬 518060 深圳大学医学部临床医学系  
张明 518060 深圳大学医学部预防医学系  
胡东生 450001 郑州大学公共卫生学院流行病与卫生统计学系 hud@szu.edu.cn 
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中文摘要:
      目的 探讨中国成年人群年龄对BMI与高血压发病风险的影响。方法 采用整群随机抽样方法,选择河南省新安县≥ 18岁20 194名农村常住居民为研究对象,于2007-2008年开展基线调查,2013-2014年随访。采用logistic回归模型分析基线BMI、年龄别BMI与高血压发病风险的关系。结果 共纳入9 768名研究对象,在6年随访期内,发生高血压1 950例,其中男性784例,女性1 166例,相应的累积发病率分别为19.96%、20.51%和19.61%。以BMI<22 kg/m2组为参照,基线BMI为22~、24~、26~、≥ 28 kg/m2的研究对象发生高血压的RR值(95%CI)分别为1.09(0.93~1.27)、1.17(1.01~1.37)、1.34(1.14~1.58)和1.31(1.09~1.56)。青中年人群随着BMI的升高,高血压发病风险呈逐渐上升趋势(P<0.05);老年人群随着BMI的增加,高血压发病风险则无显著变化趋势(P>0.05)。结论 BMI与高血压发病风险的关联受到年龄因素修饰的影响,在青中年人群中干预BMI可更有效降低高血压发病风险。
英文摘要:
      Objective To study the modification effect of age on the association between body mass index and the risk of hypertension.Methods People age ≥ 18 years old were selected by clusters, from a rural area of Henan province. In total, 20 194 people were recruited at baseline during 2007 and 2008, and the follow-up study was completed from 2013 to 2014. Logistic regression model was used to assess the risk of incident hypertension by baseline BMI and age-specific BMI.Results During the 6-year follow-up period, 1 950 hypertensive persons were detected, including 784 men and 1 166 women, with cumulative incidence rates as 19.96%, 20.51%, and 19.61%, respectively. Compared with those whose BMI<22 kg/m2, the RRs of hypertension were 1.09 (0.93-1.27), 1.17 (1.01-1.37), 1.34 (1.14-1.58) and 1.31 (1.09-1.56) for participants with BMI as 22-, 24-, 26-and ≥ 28 kg/m2, respectively. In young and middle-aged populations, the risk of hypertension gradually increased with the rise of BMI (trend P<0.05). However, in the elderly, the increasing trend on the risk of hypertension risk was not as significantly obvious (trend P>0.05).Conclusion The effect of BMI on the incidence of hypertension seemed to depend on age. Our findings suggested that a weight reduction program would be more effective on young or middle-aged populations, to prevent the development of hypertension.
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