| 张冬冬,刘雪娇,王炳源,任永成,赵阳,刘飞燕,刘徳臣,程诚,陈序,刘磊磊,周琼桂,徐琦焕,熊一涵,刘佳立,游子扬,张明,胡东生.我国成年人群年龄对体质指数与高血压发病风险的修饰效应[J].中华流行病学杂志,2018,39(6):765-769 |
| 我国成年人群年龄对体质指数与高血压发病风险的修饰效应 |
| Age-related modification effect on the association between body mass index and the risk of hypertension: A Cohort Study on Chinese people living in the rural areas |
| 收稿日期:2017-10-12 出版日期:2018-06-20 |
| DOI：10.3760/cma.j.issn.0254-6450.2018.06.014 |
| 中文关键词: 体质指数 高血压 年龄 修饰效应 队列研究 |
| 英文关键词: Body mass index Hypertension Age Modification Cohort |
| 基金项目:国家自然科学基金（81373074，81402752，81673260） |
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| 中文摘要: |
| 目的 探讨中国成年人群年龄对BMI与高血压发病风险的影响。方法 采用整群随机抽样方法，选择河南省新安县≥ 18岁20 194名农村常住居民为研究对象，于2007-2008年开展基线调查，2013-2014年随访。采用logistic回归模型分析基线BMI、年龄别BMI与高血压发病风险的关系。结果 共纳入9 768名研究对象，在6年随访期内，发生高血压1 950例，其中男性784例，女性1 166例，相应的累积发病率分别为19.96%、20.51%和19.61%。以BMI<22 kg/m2组为参照，基线BMI为22~、24~、26~、≥ 28 kg/m2的研究对象发生高血压的RR值（95%CI）分别为1.09（0.93~1.27）、1.17（1.01~1.37）、1.34（1.14~1.58）和1.31（1.09~1.56）。青中年人群随着BMI的升高，高血压发病风险呈逐渐上升趋势（P<0.05）；老年人群随着BMI的增加，高血压发病风险则无显著变化趋势（P>0.05）。结论 BMI与高血压发病风险的关联受到年龄因素修饰的影响，在青中年人群中干预BMI可更有效降低高血压发病风险。 |
| 英文摘要: |
| Objective To study the modification effect of age on the association between body mass index and the risk of hypertension.Methods People age ≥ 18 years old were selected by clusters, from a rural area of Henan province. In total, 20 194 people were recruited at baseline during 2007 and 2008, and the follow-up study was completed from 2013 to 2014. Logistic regression model was used to assess the risk of incident hypertension by baseline BMI and age-specific BMI.Results During the 6-year follow-up period, 1 950 hypertensive persons were detected, including 784 men and 1 166 women, with cumulative incidence rates as 19.96%, 20.51%, and 19.61%, respectively. Compared with those whose BMI<22 kg/m2, the RRs of hypertension were 1.09 (0.93-1.27), 1.17 (1.01-1.37), 1.34 (1.14-1.58) and 1.31 (1.09-1.56) for participants with BMI as 22-, 24-, 26-and ≥ 28 kg/m2, respectively. In young and middle-aged populations, the risk of hypertension gradually increased with the rise of BMI (trend P<0.05). However, in the elderly, the increasing trend on the risk of hypertension risk was not as significantly obvious (trend P>0.05).Conclusion The effect of BMI on the incidence of hypertension seemed to depend on age. Our findings suggested that a weight reduction program would be more effective on young or middle-aged populations, to prevent the development of hypertension. |
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