文章摘要
金鹏飞,李靖欣,朱凤才.评估疫苗群体保护的研究进展[J].中华流行病学杂志,2018,39(6):862-866
评估疫苗群体保护的研究进展
Progress in assessment of vaccine on herd protection
投稿时间:2017-05-18  
DOI:10.3760/cma.j.issn.0254-6450.2018.06.032
中文关键词: 群体保护;群体免疫;疫苗;观察性研究;群随机对照临床研究
英文关键词: Herd protection;Herd immunity;Vaccine;Observational study,Cluster-randomized clinical trial
基金项目:
作者单位E-mail
金鹏飞 210009 南京, 江苏省疾病预防控制中心疫苗临床评价所  
李靖欣 210009 南京, 江苏省疾病预防控制中心疫苗临床评价所  
朱凤才 210009 南京, 江苏省疾病预防控制中心疫苗临床评价所 jszfc@vip.sina.com 
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中文摘要:
      疫苗的公共卫生意义在于疫苗的群体保护效应,即当疫苗接种率达到一定水平时,疫苗接种将会直接保护接种人群和间接保护未接种人群。扩大疫苗接种率达到足够的群体保护是预防甚至是根除某些传染性疾病的基本策略。此外,群体保护的评价在制定公共卫生策略方面具有十分重要的作用。近年来,国外关于疫苗群体保护的研究日益增多,包括人群观察性研究和群随机对照临床研究,但国内还未见相关的文献报道。本文旨在对评价疫苗群体保护的研究设计及方法进行阐述,为我国在该领域的相关研究提供参考。
英文摘要:
      The importance of vaccine on public health is related to the herd protection related to the levels of vaccine coverage, which directly influences the vaccinated individuals as well as the unvaccinated community. Reaching the level of herd protection by increasing vaccine coverage is the basic strategy to eradicate related infectious diseases. Again, herd protection has played an important role in public health practices. With the increasing interests in estimating the vaccine herd protection, we however, have seen only few relevant papers including observational population-based and cluster-randomized clinical trials reported in China. We hope to discuss the study designs for evaluating the vaccine herd protection in order to generate evidence-based related research in this field.
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