文章摘要
梁晨,刘毅,唐神结.Toll样受体家族基因多态性与结核易感性研究进展[J].中华流行病学杂志,2018,39(8):1130-1134
Toll样受体家族基因多态性与结核易感性研究进展
Progress of research on toll-like receptors family gene polymorphism and susceptibility to tuberculosis
投稿时间:2018-03-03  
DOI:10.3760/cma.j.issn.0254-6450.2018.08.023
中文关键词: 结核病;Toll样受体;易感性;单核苷酸多态性
英文关键词: Tuberculosis;Toll-like receptors;Susceptibility;Single nucleotide polymorphism
基金项目:北京市医院管理局青苗计划(QML20161601);首都卫生科研发展专项(首发2018-1-1041)
作者单位E-mail
梁晨 101149 北京, 首都医科大学附属北京胸科医院结核病多学科诊疗中心  
刘毅 101149 北京市结核病胸部肿瘤研究所细菌免疫实验室 liuyilotus@hotmail.com 
唐神结 101149 北京, 首都医科大学附属北京胸科医院结核病多学科诊疗中心 tangsj1106@sina.com 
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中文摘要:
      结核病是由结核分枝杆菌引起的慢性传染性疾病。固有免疫在对结核分枝杆菌的应答中起到重要的作用,其中Toll样受体(TLRs)是固有免疫中一种重要的模式识别受体,它是激活固有免疫的一个开关,在识别病原体相关成分的过程中举足轻重。TLR1、TLR2、TLR4、TLR9在结核分枝杆菌感染过程中对菌体相关成分进行识别从而促进固有免疫应答,其中TLR1基因的单核苷酸多态性位点rs4833095、rs5743618、rs3923647,TLR2基因的rs57473708、rs3804099位点和TLR9基因的rs352139、rs5743836等位点的变异在某些人群中与结核易感性密切相关,而TLR3、TLR6、TLR7、TLR8、TLR10基因多态性与结核易感性存在一定关系。TLRs功能的正常发挥保证了机体对结核分枝杆菌正常免疫反应。TLRs基因的多样性使不同个体应对相同的病原体产生不同的反应。对TLRs单核苷酸多态性位点与结核易感性关系的研究,可以预测某些人群的结核病易感倾向,提供药物新靶点。
英文摘要:
      Tuberculosis is a chronic infectious disease caused by Mycobacterium (M.) tuberculosis. Innate immunity plays an important role in the response to M. tuberculosis. Toll-like receptors (TLRs) are important pattern recognition receptors in innate immunity. TLRs serve as switches that play decisive roles in identifying pathogens-related components. Previous studies found that TLR1, TLR2, TLR4, TLR9 were essential to promote the development of innate immune responses. The SNPs of rs4833095, rs5743618, rs3923647 of TLR1, rs57473708, rs3804099 of TLR2 and rs352139, rs5743836 of TLR9 were closely related to the susceptibility of tuberculosis in some populations. And there appeared certain relationship between the polymorphisms of TLR3, TLR6, TLR7, TLR8, TLR10 and the susceptibility of tuberculosis. The normal function of TLRs ensures the body's normal immune response to M. tuberculosis. The diversity of TLRs genes allows different individuals to respond differently to the same pathogen. Studies targeting on the relationship between single nucleotide polymorphism in TLRs and susceptibility to tuberculosis can predict the susceptibility to tuberculosis in some populations, as well as discover new drugs targets.
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