文章摘要
樊圆圆,邵建国,黄鹏,田亭,李军,韩亚萍,岳明,章莉莉.核转录因子κB基因多态性与人群感染丙型肝炎病毒的关联性[J].中华流行病学杂志,2018,39(9):1261-1264
核转录因子κB基因多态性与人群感染丙型肝炎病毒的关联性
Association between nuclear factor kappa-light-chain-enhancer of activated B cells genetic polymorphisms and HCV susceptibility among the Chinese population under high-risk
投稿时间:2017-12-01  
DOI:10.3760/cma.j.issn.0254-6450.2018.09.022
中文关键词: 丙型肝炎病毒;易感性;危险因素;核转录因子κB基因
英文关键词: Hepatitis C virus;Susceptibility;Risk factor;Nuclear factor kappa-light-chain-enhancer of activated B cells
基金项目:国家自然科学基金(81502853,81773499,81703273,81473029);江苏省自然科学基金(BK20151026,BK20171054);江苏省卫计委“科教强卫工程”青年医学人才项目(QNRC2016616);江苏省卫计委医学创新团队项目(CXTDA2017023)
作者单位E-mail
樊圆圆 210029 南京医科大学第一附属医院感染病科  
邵建国 226000 南通市第三人民医院消化科  
黄鹏 211166 南京医科大学公共卫生学院流行病学系传染病重点实验室  
田亭 211166 南京医科大学公共卫生学院流行病学系传染病重点实验室  
李军 210029 南京医科大学第一附属医院感染病科  
韩亚萍 210029 南京医科大学第一附属医院感染病科  
岳明 210029 南京医科大学第一附属医院感染病科 njym08@163.com 
章莉莉 210029 南京医科大学第一附属医院感染病科 dr.zhanglili@gmail.com 
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中文摘要:
      目的 探索核转录因子κBNF-κB)基因多态性与人群感染HCV的关联性。方法 本研究共纳入1 679位研究对象(503位吸毒者和1 176位高危血源性暴露者)。通过logistic回归分析人群感染HCV的相关因素,通过TaqMan-MGB探针法对NF-κB1基因rs72696119和REL基因rs13031237位点进行基因分型,并分析其与HCV易感性的相关性。结果 在吸毒人群中,女性吸毒者(OR=0.408,95% CI:0.308~0.767)HCV易感性更低,而静脉注射吸毒(OR=8.817,95% CI:5.577~13.937)以及吸毒时间>5.5年(OR=2.891,95% CI:1.824~4.583)则是感染HCV的危险因素。在高危血源暴露人群中,小学以上文化程度(OR=0.613,95% CI:0.429~0.876)是该高危人群感染HCV的保护因素,而女性(OR=3.431,95% CI:2.360~4.988)则是感染HCV的危险因素。在总人群中,携带NF-κB1 rs72696119 GG基因型的个体更易感染HCV(OR=1.412,95% CI:1.035~1.927)。总人群中的交互作用分析显示,rs72696119与HCV感染途径、性别均不存在交互作用(P>0.05)。结论 在高危人群中,相关的行为因素和NF-κB1基因rs72696119多态性与HCV易感性相关。
英文摘要:
      Objective To explore the association between nuclear factor kappa-light-chain-enhancer of activated genetic polymorphisms in B cells (NF-κB) and the HCV susceptibility, among the Chinese population. Methods A total of 1 679 participants were enrolled; including 503 drug users and 1 176 other participants at risk under the exposure for blood. By using the logistic regression analysis, related risk factors for HCV infection among subjects were analyzed. Two NF-κB pathway variants, NF-κB1 rs72696119 and REL rs13031237 were then genotyped by TaqMan assay method. Logistic regression analysis was performed to analyze the association between gene polymorphisms and the susceptibility on HCV. Results Among the drug users, women (OR=0.408, 95% CI:0.308-0.767) appeared to be associated with the decreased risk for HCV infection, while factors as drug injection (OR=8.817, 95% CI:5.577-13.937) and the duration of drug-intake >5.5 years (OR=2.891, 95% CI:1.824-4.583) were associated with the increased risk for HCV infection. Among the participants who had been exposed to blood, women (OR=3.431, 95% CI:2.360-4.988) were associated with the increased risk for HCV infection, while the levels of education beyond elementary school (OR=0.613, 95% CI:0.429-0.876) were associated with the decreased risk for HCV infection. Compared to the reference NF-κB1 rs72696119 CC genotype, the carriage of GG genotype was associated with an increased risk of susceptibility on HCV (OR=1.412, 95% CI:1.035-1.927) among the total study population. Results from the interaction analysis showed that there was no interactive effects appeared between rs72696119 and route of infection, or between rs72696119 and gender among the total population under study (all P>0.05). Conclusion NF-κB1 polymorphism rs72696119 and related factors seemed associated with the susceptibility to HCV infection among high-risk Chinese populations.
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