| 游楠楠,刘巧,竺丽梅,陆伟.卡介苗接种与复种的研究进展[J].中华流行病学杂志,2018,39(11):1519-1523 |
| 卡介苗接种与复种的研究进展 |
| Progress in research of bacillus calmette-guerin vaccination and repeated vaccination |
| 收稿日期:2018-05-11 出版日期:2018-11-15 |
| DOI：10.3760/cma.j.issn.0254-6450.2018.11.019 |
| 中文关键词: 结核病 卡介苗 接种 复种 |
| 英文关键词: Tuberculosis Bacillus balmette-guerin Vaccination Repeated vaccination |
| 基金项目:“六个一工程”拔尖人才科研项目（LGY2017083） |
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| 中文摘要: |
| 结核病作为严重威胁人类健康的重大传染病，卡介苗是目前唯一被证实有效的结核病疫苗，新生儿接种可以大大减少结核病的发病和死亡，但因其保护期有限，出生后接种一次并不能对青少年和成年人产生保护效果。本文通过PubMed、中国知网（CNKI）、万方数据知识服务平台等数据库的相关文献的检索和阅读，对卡介苗特性、免疫效果及免疫持久力、青少年或成年人卡介苗接种及卡介苗复种效果的研究进行了分析和总结，并结合WHO关于卡介苗使用立场发布的3次文件，探讨其对于卡介苗使用的态度转变历程以及今后的政策趋势。 |
| 英文摘要: |
| Tuberculosis (TB) is a serious infectious diseases threating human health, bacillus balmette-guerin vaccine (BCG) is the only available TB vaccine now, neonatal vaccination can significantly reduce the incidence and death of tuberculosis. However, due to its limited protection period, one dose vaccination after birth does not have a protective effect for adolescents and adults. Therefore, how to reduce the prevalence of TB in adolescents and adults effectively is essential for TB prevention and control. In this paper, we reviewed the literature from PubMed, CNKI, and Wanfang database to analyze and summarize the characteristics of BCG vaccine, immune effects and immunity endurance, the effects of BCG vaccination and repeated BCG vaccination in adolescents adults and discuse the change of attitude and trends of BCG use in the three documents issued by the World Health Organization on position of BCG. |
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