文章摘要
孟子延,张家友,张哲罡,罗丹,杨晓明.四价流感病毒灭活疫苗在18~64岁人群免疫原性和安全性的系统综述和Meta分析[J].中华流行病学杂志,2018,39(12):1636-1641
四价流感病毒灭活疫苗在18~64岁人群免疫原性和安全性的系统综述和Meta分析
Immunogenicity of inacitivated quadrivalent influenza vaccine in adults aged 18-64 years: A systematic review and Meta-analysis
投稿时间:2018-07-09  
DOI:10.3760/cma.j.issn.0254-6450.2018.12.019
中文关键词: 流感疫苗;灭活疫苗;免疫原性;随机对照试验;Meta分析;四价流感疫苗
英文关键词: Influenza vaccine;Vaccines, inactivated;Immunogenicity;Random control trial;Meta-analysis;Quadrivalent influenza vaccine
基金项目:
作者单位E-mail
孟子延 430207 武汉, 国家联合疫苗工程技术研究中心
430207 武汉生物制品研究所 
 
张家友 430207 武汉, 国家联合疫苗工程技术研究中心
430207 武汉生物制品研究所 
 
张哲罡 430207 武汉, 国家联合疫苗工程技术研究中心
430207 武汉生物制品研究所 
 
罗丹 430207 武汉, 国家联合疫苗工程技术研究中心
430207 武汉生物制品研究所 
 
杨晓明 430207 武汉, 国家联合疫苗工程技术研究中心 yangxiaoming@sinopharm.com 
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中文摘要:
      目的 用Meta分析的方法评价四价流感病毒灭活疫苗在18~64岁人群的免疫原性(抗体保护率和抗体阳转率)。方法 检索Medline、Cochrane Library、Science Direct数据库,将近10年内发表的比较18~64岁人群接种四价流感病毒灭活疫苗和三价流感病毒灭活疫苗免疫原性的临床随机对照试验纳入分析。采用Revman 5.3软件对纳入文献数据进行Meta分析。结果 共纳入8篇文献,针对甲型流感株(A/H1N1、A/H3N2)的抗体保护率和抗体阳转率,两种疫苗的反应差异无统计学意义;针对不含乙型流感株B/Victoria的三价流感病毒灭活疫苗,四价流感病毒灭活疫苗抗体保护率的合并RR值为1.28(95% CI:1.08~1.51,P<0.05),抗体阳转率的合并RR值为1.94(95% CI:1.50~2.50,P<0.05);针对不含乙型流感株B/Yamagata的三价流感病毒灭活疫苗,四价流感病毒疫苗抗体保护率的合并RR值为1.10(95% CI:1.02~1.18,P<0.05),抗体阳转率的合并RR值为1.99(95% CI:1.34~2.97,P<0.05),差异有统计学意义。结论 18~64岁人群中,四价流感病毒灭活疫苗与三价流感病毒灭活疫苗对于相同的疫苗株产生的免疫原性无差异,对于三价流感病毒灭活疫苗中不含的乙型疫苗株能产生良好的免疫效果。
英文摘要:
      Objective To evaluate the immunogenicity of inactivated quadrivalent influenza vaccine (QIV) in adults aged 18-64 years, through a Meta-analysis. Methods Literature was retrieved by searching the Medline, Cochrane Library, Science Direct in the past decade. All the studies were under random control trial (RCT) and including data related to immunogenicity which involving sero-protection rate (SPR) and sero-conversion rate (SCR) of the QIV, versus inactivated trivalent influenza vaccine (TIV) in the population aged 18 to 64. Revman 5.3 software was employed to manipulate the pooled date of the included literature. Result A total of 8 studies for the SPR and SCR of the shared strains (two A lineage and one B lineage) were included. There appeared no significant differences in the response rates between the two vaccines. As for QIV versus TIV (B/Yamagata), the pooled RR of the SPR for B/Victoria was 1.28 (95% CI:1.08-1.51, P<0.05), with the pooled RR of the SCR for B/Victoria as 1.94 (95% CI:1.50-2.50, P<0.05). For QIV versus TIV (B/Victoria), the pooled RR of the SPR for B/Yamagata as 1.10 (95% CI:1.02-1.18, P<0.05), and the pooled RR of SCR for B/Yamagata as 1.99 (95% CI:1.34-2.97, P<0.05). Conclusion In the population aged 18-64 years, inactivated QIV was equivalently immunogenic against the shared three strains included in the activated TIV while a superior immunogenic effect was noticed in the vaccine strain which did not include the inactivated QIV.
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