文章摘要
孟玲先,阙喜妹,高雪,王彤.儿童肥胖与冠状动脉疾病的孟德尔随机化研究[J].中华流行病学杂志,2019,40(7):839-843
儿童肥胖与冠状动脉疾病的孟德尔随机化研究
Childhood obesity and coronary artery disease:a Mendelian randomization study
投稿时间:2018-11-14  
DOI:10.3760/cma.j.issn.0254-6450.2019.07.019
中文关键词: 孟德尔随机化研究;儿童肥胖;冠状动脉疾病
英文关键词: Mendelian randomization;Childhood obesity;Coronary artery disease
基金项目:国家自然科学基金(81872715, 81473073)
作者单位E-mail
孟玲先 山西医科大学公共卫生学院, 太原 030001  
阙喜妹 山西医科大学公共卫生学院, 太原 030001  
高雪 山西医科大学公共卫生学院, 太原 030001  
王彤 山西医科大学公共卫生学院, 太原 030001 tongwang@sxmu.edu.cn 
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中文摘要:
      目的 利用孟德尔随机化研究(MR)方法评估儿童肥胖与冠状动脉疾病(CAD)是否具有因果关联。方法 利用早期生长遗传学数据库和人体测量学特征遗传学研究数据库中2015年2~10岁儿童BMI的汇总数据,选取27个与儿童BMI相关的遗传变异作为工具变量。从对欧洲最大队列UK Biobank 2015年发布的CAD病例全基因组关联研究的Meta分析中,提取工具变量与CAD汇总水平的关联结果。采用MR-Egger方法进行工具变量的多效性检验,使用基于众数的方法进行MR分析检验儿童肥胖与CAD是否具有因果关联。结果 MR-Egger回归得到的截距项95% CI包含0(-0.008~0.018),提示所选取的工具变量不具有多效性。儿童BMI每增加1个标准差,成年期患CAD的风险增加37%(OR=1.37,95% CI:1.09~1.72)。结论 儿童肥胖可能与其成年期患CAD的风险具有因果关联。
英文摘要:
      Objective To assess the casual effect of childhood obesity on adulthood coronary artery disease (CAD) using Mendelian randomization (MR) method. Methods Data on BMI of children aged 2-10 years in 2015 were downloaded from Early Growth Genetics Consortium and Genetic Investigation of Anthropometric Traits Consortium. Twenty-seven genetic variants related to children's BMI were selected as instrumental variables (IVs), and the associations between IVs and CAD were extracted from a Meta-analysis of the genome-wide association study of CAD cases published in UK Biobank 2015. We used MR-Egger regression to test whether there was the pleiotropy of the selected SNPs. In the present MR methods, we conducted MR analyses by using mode-based estimate method as primary method for summary-level of associations to estimate the causal association between childhood obesity and CAD. Results The intercept term estimated for CAD from MR-Egger method suggested that the selected SNPs don't exert pleiotropy with a 95%CI including the null (-0.008-0.018). In addition, we found evidence that support the effect of childhood obesity on CAD risk:a 1 s increase in children BMI (kg/m2), and the risk of suffering from CAD in adulthood increased by an average of 37% (OR=1.37, 95%CI:1.09-1.72). Conclusion This study provides a causal association between childhood obesity and CAD risk.
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