文章摘要
屠丽红,林声,张驰,袁政安,张曦,陈敏,陈洪友,潘浩.上海市2013-2016年门诊腹泻患者弯曲菌流行特征及耐药研究[J].中华流行病学杂志,2019,40(8):900-903
上海市2013-2016年门诊腹泻患者弯曲菌流行特征及耐药研究
Epidemiological characteristics and antibiotic resistance of Campylobacter spp. among diarrhea outpatients in Shanghai, 2013-2016
投稿时间:2019-03-08  
DOI:10.3760/cma.j.issn.0254-6450.2019.08.006
中文关键词: 腹泻病;弯曲菌;耐药性
英文关键词: Diarrhea;Campylobacter spp.;Antibiotic resistance
基金项目:上海市第四轮公共卫生三年行动计划高端海外研修团队培养计划(GWTD2015S01);国家传染病防治科技重大专项(2017ZX10103009-003)
作者单位E-mail
屠丽红 上海市疾病预防控制中心 200336  
林声 上海市疾病预防控制中心 200336  
张驰 上海市疾病预防控制中心 200336  
袁政安 上海市疾病预防控制中心 200336  
张曦 上海市疾病预防控制中心 200336 zhangxi@scdc.sh.cn 
陈敏 上海市疾病预防控制中心 200336  
陈洪友 上海市疾病预防控制中心 200336  
潘浩 上海市疾病预防控制中心 200336  
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中文摘要:
      目的 了解2013-2016年上海市门诊腹泻患者弯曲菌流行特征及耐药情况。方法 2013-2016年,采用膜过滤法对上海市23家医院肠道门诊腹泻病例粪便肛拭标本开展弯曲菌检测,并用常规生化试验和PCR方法鉴定分离菌株。采用微量肉汤稀释法对弯曲菌进行8种抗菌药物(阿奇霉素、环丙沙星、红霉素、庆大霉素、四环素、萘啶酸、泰利霉素、克林霉素)敏感试验。结果 在10 444例腹泻患者粪便肛拭标本中共分离到179株弯曲菌,检出率为1.7%,其中空肠弯曲菌占94.4%,结肠弯曲菌占5.6%。不同年龄人群弯曲菌检出率存在差异,儿童的检出率比成年人高。4-6月和10-12月是弯曲菌的发病高峰。空肠弯曲菌对环丙沙星、四环素、萘啶酸的耐药率高,为96.4%、83.4%、81.7%,结肠弯曲菌耐药率高于空肠弯曲菌,人源弯曲菌存在多重耐药菌株。结论 弯曲菌是上海市腹泻病门诊重要病原体之一,存在不同年龄人群、不同季节的分布差异。上海市人源弯曲菌对环丙沙星、四环素、萘啶酸的耐药情况严重。
英文摘要:
      Objective To understand the epidemiological characteristics and antibiotic resistance profiles of Campylobacter spp. in Shanghai from 2013 to 2016. Methods Stool samples collected from diarrhea outpatients were cultured for Campylobacter spp., using the membrane filter method in 23 hospitals under the sentinel programs, from 2013 to 2016. All the strains were identified by biochemical tests and PCR. Broth microdilution method was used to investigate the antibiotic resistance of 179 Campylobacter spp. strains that including azithromycin, ciprofloxacin, erythromycin, gentamicin, tetracycline, nalidixic acid, telycin, klinthromycin and flurbenicol. Results A total of 179 Campylobacter spp. strains were isolated from 10 444 stool samples (1.7%). Campylobacter jejuni and Campylobacter coli appeared as the predominant ones (94.4% and 5.6%). The incidence rate was higher in children than that in adults, with peaks of infections mainly from April to June and October to December. Campylobacter jejuni strains seemed highly resistant to ciprofloxacin (96.4%), tetracycline (83.4%) and nalidixic acid (81.7%). The resistant rates appeared higher on Campylobacter coli strains that isolated from patients. Some strains were resistant to multi-drugs. Conclusions Campylobacter spp. seemed one of the important pathogens that isolated from outpatients with diarrhea, in Shanghai. Both age and season related characteristics of Campylobacter spp. were seen. Campylobacter spp. isolated from patients was highly resistant to ciprofloxacin, tetracycline and nalidixic acid.
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