文章摘要
乔亚萍,王潇滟,苏敏,王前,李珍,金曦,王爱玲.2015-2017年中国HIV暴露儿童艾滋病感染早期诊断检测情况分析[J].中华流行病学杂志,2019,40(9):1111-1115
2015-2017年中国HIV暴露儿童艾滋病感染早期诊断检测情况分析
HIV early infant diagnosis test in HIV-exposed children in China, 2015-2017
投稿时间:2019-01-21  
DOI:10.3760/cma.j.issn.0254-6450.2019.09.017
中文关键词: HIV暴露儿童;儿童艾滋病感染早期诊断;死亡;覆盖面
英文关键词: HIV-exposed children;Early infant diagnosis;Mortality;Coverage
基金项目:国家科技重大专项(2015ZX10001001)
作者单位E-mail
乔亚萍 中国疾病预防控制中心妇幼保健中心, 北京 100081  
王潇滟 中国疾病预防控制中心妇幼保健中心, 北京 100081  
苏敏 中国疾病预防控制中心妇幼保健中心, 北京 100081  
王前 中国疾病预防控制中心妇幼保健中心, 北京 100081  
李珍 中国疾病预防控制中心妇幼保健中心, 北京 100081  
金曦 中国疾病预防控制中心妇幼保健中心, 北京 100081  
王爱玲 中国疾病预防控制中心妇幼保健中心, 北京 100081 maternal2019@163.com 
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中文摘要:
      目的 分析我国HIV暴露儿童接受儿童艾滋病感染早期诊断(early infant diagnosis,EID)检测服务情况并探讨其相关影响因素。方法 利用全国预防艾滋病母婴传播管理信息系统,收集HIV感染孕产妇分娩儿童随访卡,回顾性分析我国2015-2017年随访满18月龄的12 096例HIV暴露儿童队列数据。描述HIV暴露儿童EID检测特征,分析EID检测相关影响因素。结果 2015-2017年我国HIV暴露儿童EID检测率自65.6%增加至83.4%(趋势性χ2检验P<0.001),出生后8周内EID检测比例自61.1%增加至76.8%(趋势性χ2检验P<0.001),EID检测阳性率自8.7%降低至3.4%(趋势性χ2检验P<0.001)。2015-2017年死亡儿童EID检测阳性率分别为47.7%、36.9%和36.3%,差异无统计学意义。多因素分析发现HIV暴露儿童民族、地区、满18月龄和存活情况与接受EID检测之间存在关联,差异有统计学意义(P<0.001)。结论 我国EID检测工作逐步规范落实,EID检测阳性率逐年降低,但18月龄内死亡儿童,少数民族和HIV低发区儿童的EID检测比例较低。
英文摘要:
      Objective To understand the early infant diagnosis (EID) test rate and associated factors in HIV-exposed children in China during 2015-2017. Methods The follow-up information cards of 12 096 HIV-exposed children for 18 months after birth during 2015-2017 were collected from the Management Information System of China's Prevention of Mother-to-Child Transmission of HIV for a retrospective analysis. The EID test characteristics of HIV exposed children and associated factors were analyzed. Results From 2015 to 2017, the EID test rate in HIV exposed children increased from 65.6% to 83.4% in China (trend χ2 P<0.001). The EID test rate within 8 weeks after birth increased from 61.1% to 76.8% (trend χ2 P<0.001), but the EID positive rate decreased from 8.7% to 3.4% (trend χ2 P<0.001). The EID positive rate in fatal HIV-exposed children was 47.7%, 36.9% and 36.3% during 2015-2017, respectively, the differences were not significant. EID test rate was associated with ethnic group, living area, survival status and the year reaching 18-month-old of the children. Conclusions The performance of EID test has been standardized step by step in China. The positive rate of EID test decreased gradually with year. However, the EID test rates in children who were from minority ethnic groups, lived in areas with lower prevalence of HIV infection and died within 18 months after birth were relatively low.
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