文章摘要
李敏敏,张彬艳,石国帅,虢海月,李姗姗,武文韬,米白冰,党少农,颜虹.育龄妇女孕早期患病与新生儿先天性心脏病的关联[J].中华流行病学杂志,2019,40(9):1130-1133
育龄妇女孕早期患病与新生儿先天性心脏病的关联
Association between congenital heart disease and maternal disease in early pregnancy in women of childbearing age
投稿时间:2019-03-11  
DOI:10.3760/cma.j.issn.0254-6450.2019.09.021
中文关键词: 先天性心脏病;孕早期患病;倾向值匹配
英文关键词: Congenital heart disease;Maternal disease;Propensity score
基金项目:国家自然科学基金(81230016);陕西省卫生和计划生育委员会出生缺陷防治课题(sxwsjswzfcght2016-013)
作者单位E-mail
李敏敏 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061  
张彬艳 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061  
石国帅 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061  
虢海月 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061  
李姗姗 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061  
武文韬 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061  
米白冰 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061  
党少农 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061 tjdshn@mail.xjtu.edu.cn 
颜虹 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061  
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中文摘要:
      目的 探讨育龄妇女孕早期患病与新生儿先天性心脏病之间的关联。方法 采用分层多阶段随机抽样方法,以问卷调查方式收集2010-2013年陕西省怀孕且结局明确的育龄妇女及其子女的相关信息。应用倾向值匹配法,对孕早期患病组和未患病组育龄妇女进行1 ∶ 1匹配。以是否生育先天性心脏病患儿为因变量,以母亲孕早期是否患病为自变量,通过逐步校正混杂因素建立logistic回归模型。结果 共纳入28 680对母亲及新生儿,孕早期患病者5 807人(20.25%)。匹配后孕早期患病组和未患病组分别为5 436人。在控制混杂因素后,母亲孕早期患病可增加新生儿先天性心脏病的发病风险(OR=1.86,95% CI:1.23~2.81),孕早期患感冒(OR=2.19,95% CI:1.46~3.28)、妇科疾病(OR=4.74,95% CI:2.03~11.09)和糖尿病(OR=14.00,95% CI:1.64~119.21)是生育先天性心脏病患儿的危险因素。结论 育龄妇女孕早期患感冒、妇科疾病和糖尿病与子代发生先天性心脏病有关。
英文摘要:
      Objective To investigate the relationship between maternal disease in early pregnancy of women of childbearing age and congenital heart disease of neonates. Methods A cross-sectional design was used in this study and stratified multistage random sampling method was used. A questionnaire survey was conducted in the childbearing-aged women during 2010-2013 in Shaanxi province. Propensity score (PS) matched (1:1) analysis was used to match participants with diseases to those without disease in early pregnancy. Through the control of the confounders step by step, a logistic regression model was established to evaluate the ORs of congenital heart disease according to the independent variable of maternal disease. Results A total of 28 680 pairs of mothers and infants were included in this study, the proportion of the women with disease in early pregnancy was 20.25% (5 807). After PS matching, 5 436 pairs were matched. After adjusting all confounding factors, the multivariable logistic regression analysis results showed that maternal disease (OR=1.86, 95%CI:1.23-2.81), especially cold (OR=2.19, 95%CI:1.46-3.28), gynecological disease (OR=4.74, 95%CI:2.03-11.09) and diabetes (OR=14.00, 95%CI:1.64-119.21), in early pregnancy were the risk factors for congenital heart disease of neonate. Conclusion In women of childbearing age, disease in early pregnancy, especially cold, gynecological disease and diabetes, can increase the risk of congenital heart disease in neonates.
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