文章摘要
甘梦泽,冯毅,邢辉.基于分子网络方法研究HIV感染者传播特征的相关进展[J].中华流行病学杂志,2019,40(11):1487-1491
基于分子网络方法研究HIV感染者传播特征的相关进展
Progress in research on the transmission characteristics of HIV-infected persons based on molecular network method
收稿日期:2019-03-29  出版日期:2019-11-26
DOI:10.3760/cma.j.issn.0254-6450.2019.11.026
中文关键词: 艾滋病病毒;分子网络;传播特征;传播网络
英文关键词: HIV;Molecular network;Transmission characteristics;Transmission network
基金项目:国家科技重大专项(2017ZX10201101);国家自然科学基金(81471962,81261120393);北京市科技计划项目(D161100000416002)
作者单位E-mail
甘梦泽 中国疾病预防控制中心性病艾滋病预防控制中心 传染病预防控制国家重点实验室, 北京 102206  
冯毅 中国疾病预防控制中心性病艾滋病预防控制中心 传染病预防控制国家重点实验室, 北京 102206  
邢辉 中国疾病预防控制中心性病艾滋病预防控制中心 传染病预防控制国家重点实验室, 北京 102206 xingh@chinaaids.cn 
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中文摘要:
      HIV分子网络是近期被广泛报道的一种研究HIV感染者传播特征的方法,各国利用此方法在传播关系、传播热点、疫情监控等方面进行了大量的研究,有望为实现精确干预和防控提供依据。目前国际上主要报道有3种构建分子网络的方法:基于两两比对基因距离法、基于系统进化树节点校验值法、基于两者联合参数法。本文综述3种构建HIV分子网络方法研究HIV感染者传播特征的相关进展,以期为应用于指导防控HIV提供数据支撑。自分子网络方法出现以来,我国北京市、上海市、浙江省、四川省等陆续报道了应用分子网络方法分析的相关研究结果,为进一步开展精准防控提供了科学数据。近期国际上相关研究也预测基于分子网络的传播簇检测有望成为终结艾滋病流行的一种新方法。
英文摘要:
      HIV molecular network is a recently reported method for studying the transmission characteristics of HIV-infected people. Countries have used this method to conduct a large number of researches on transmission relations, transmission hotspots and epidemic surveillance for the purpose of providing evidence for precise AIDS intervention and control. At present, there are three major methods for constructing molecular networks in the world, i.e. genetic distance method based on pairwise alignment, phylogenetic node support method, and joint parameter method based on the two methods. This paper reviews the progress of the three methods for constructing HIV molecular network to study the transmission characteristics of HIV-infected patients, in order to provide data support for the prevention and control of HIV. Since the emergence of the molecular network method, Beijing, Shanghai, Zhejiang, Sichuan and other provinces in China have reported relevant research results using molecular network analysis, which provided scientific data for further precise AIDS prevention and control. Recent international studies have also predicted that molecular network based transmission cluster detection is expected to become a new method to stop AIDS epidemic.
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