文章摘要
俞顺章.通过“预防为主”切断母婴传播促进我国乙型肝炎和肝癌发病率持续下降[J].中华流行病学杂志,2019,40(12):1650-1653
通过“预防为主”切断母婴传播促进我国乙型肝炎和肝癌发病率持续下降
Facilitating the continuous decline on the incidence rates of hepatitis B and liver cancer through cutting off the mother-to-child viral transmission, based on the “prevention first” strategy, in China
收稿日期:2019-07-28  出版日期:2019-12-20
DOI:10.3760/cma.j.issn.0254-6450.2019.12.027
中文关键词: 母婴传播  肝癌  消灭肝炎和控制肝癌
英文关键词: Mother-infant-transmission  Hepatocellular carcinoma  Elimination viral hepatitis and control of HCC
基金项目:
作者单位E-mail
俞顺章 复旦大学公共卫生学院, 上海 200032 szyu@shmu.edu.cn 
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中文摘要:
      全世界共有600万~1 000万乙型肝炎(乙肝)慢性患者,联合国制定的《2030年可持续发展议程》中要求消灭肝炎,并要求到2030年减少90%慢性患者。上海市接种乙肝疫苗后,乙肝发病率已减少了85%,肝癌发病率下降1/2。2015年,联合国要求乙肝母婴传播阻断成功率要达到95%以上,乙肝新感染人数要减少90%。为了早日实现联合国目标,根据上海市经验,建议在乙肝疫苗接种阻断母婴传播时,坚持做到"3个96%",即婴儿出生24 h内接种率达到96%,出生后1、6个月疫苗加强时继续2个96%。抓住切断母婴传播关键环节,我国预防肝炎定有希望,有可能提前达到消灭乙肝和控制肝癌的任务。
英文摘要:
      There have been 6-10 million reported patients with chronic hepatitis B virus (HBV) infection worldwide, and the United Nations (UN) called for a "90% reduction by 2030" strategy. Since the wide practice of HBV vaccination, the numbers of HBV cases have been reduced by 85% and the incidence of hepatocellular carcinoma has also decreased by 50%. As formulated by the UN in 2015, the sustainable development agenda for the eradication of hepatitis B included the success rate of preventing mother-to-child viral transmission by 95%, together with the reduction of new hepatitis B infections by 90% in 2030. In order to achieve the agenda, we proposed a strategy to achieve the "three 96%" goals derived from the Shanghai experience. In brief, hepatitis B vaccine should cover for 96% newborns within 24 h, and the vaccination boosting rate should reach 96% for both one and six months after birth. If cutting off the mother-to-child viral transmission strategy can be successfully achieved, the future of hepatitis B prevention will be promising, and the task of eliminating hepatitis B and controlling hepatocellular carcinoma can be completed ahead of 2030, time proposed by the UN.
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