| 俞顺章.通过“预防为主”切断母婴传播促进我国乙型肝炎和肝癌发病率持续下降[J].中华流行病学杂志,2019,40(12):1650-1653 |
| 通过“预防为主”切断母婴传播促进我国乙型肝炎和肝癌发病率持续下降 |
| Facilitating the continuous decline on the incidence rates of hepatitis B and liver cancer through cutting off the mother-to-child viral transmission, based on the “prevention first” strategy, in China |
| 收稿日期:2019-07-28 出版日期:2019-12-20 |
| DOI：10.3760/cma.j.issn.0254-6450.2019.12.027 |
| 中文关键词: 母婴传播 肝癌 消灭肝炎和控制肝癌 |
| 英文关键词: Mother-infant-transmission Hepatocellular carcinoma Elimination viral hepatitis and control of HCC |
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| 中文摘要: |
| 全世界共有600万~1 000万乙型肝炎（乙肝）慢性患者，联合国制定的《2030年可持续发展议程》中要求消灭肝炎，并要求到2030年减少90%慢性患者。上海市接种乙肝疫苗后，乙肝发病率已减少了85%，肝癌发病率下降1/2。2015年，联合国要求乙肝母婴传播阻断成功率要达到95%以上，乙肝新感染人数要减少90%。为了早日实现联合国目标，根据上海市经验，建议在乙肝疫苗接种阻断母婴传播时，坚持做到"3个96%"，即婴儿出生24 h内接种率达到96%，出生后1、6个月疫苗加强时继续2个96%。抓住切断母婴传播关键环节，我国预防肝炎定有希望，有可能提前达到消灭乙肝和控制肝癌的任务。 |
| 英文摘要: |
| There have been 6-10 million reported patients with chronic hepatitis B virus (HBV) infection worldwide, and the United Nations (UN) called for a "90% reduction by 2030" strategy. Since the wide practice of HBV vaccination, the numbers of HBV cases have been reduced by 85% and the incidence of hepatocellular carcinoma has also decreased by 50%. As formulated by the UN in 2015, the sustainable development agenda for the eradication of hepatitis B included the success rate of preventing mother-to-child viral transmission by 95%, together with the reduction of new hepatitis B infections by 90% in 2030. In order to achieve the agenda, we proposed a strategy to achieve the "three 96%" goals derived from the Shanghai experience. In brief, hepatitis B vaccine should cover for 96% newborns within 24 h, and the vaccination boosting rate should reach 96% for both one and six months after birth. If cutting off the mother-to-child viral transmission strategy can be successfully achieved, the future of hepatitis B prevention will be promising, and the task of eliminating hepatitis B and controlling hepatocellular carcinoma can be completed ahead of 2030, time proposed by the UN. |
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