文章摘要
张露,范志芳,刘殿武,周脉耕,王卓群,李曼.1990-2016年中国乙型肝炎引起的肝硬化及其他慢性肝病疾病负担变化趋势分析[J].中华流行病学杂志,2020,41(2):173-177
1990-2016年中国乙型肝炎引起的肝硬化及其他慢性肝病疾病负担变化趋势分析
Trend analysis on the disease burden related to cirrhosis and other chronic liver diseases caused by hepatitis B, in China, from 1990 to 2016
投稿时间:2019-07-08  
DOI:10.3760/cma.j.issn.0254-6450.2020.02.007
中文关键词: 乙型肝炎;肝硬化;疾病负担;伤残调整寿命年
英文关键词: Hepatitis B;Cirrhosis;Burden of disease;Disability adjusted life year
基金项目:
作者单位E-mail
张露 河北医科大学公共卫生学院流行病与卫生统计学教研室 河北省环境与人群健康重点实验室, 石家庄 050017  
范志芳 河北医科大学公共卫生学院流行病与卫生统计学教研室 河北省环境与人群健康重点实验室, 石家庄 050017  
刘殿武 河北医科大学公共卫生学院流行病与卫生统计学教研室 河北省环境与人群健康重点实验室, 石家庄 050017  
周脉耕 中国疾病预防控制中心慢性非传染性疾病预防控制中心, 北京 100050  
王卓群 中国疾病预防控制中心慢性非传染性疾病预防控制中心, 北京 100050  
李曼 河北医科大学公共卫生学院流行病与卫生统计学教研室 河北省环境与人群健康重点实验室, 石家庄 050017 lm772003@163.com 
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中文摘要:
      目的 分析1990-2016年中国乙型肝炎引起的肝硬化及其他慢性肝病导致的疾病负担变化情况,为其防治策略的制定提供科学依据。方法 利用2016年全球疾病负担(GBD2016)研究结果,分析1990-2016年中国乙型肝炎引起的肝硬化及其他慢性肝病的患病率、死亡率和伤残调整寿命年(DALY)的变化趋势。结果 与1990年相比,中国 2016年乙型肝炎引起的肝硬化及其他慢性肝病患病和死亡人数分别增加了79.6%和2.4%。患病率增加了49.2%,男性患病率的增幅(50.3%)高于女性(42.3%),15~49岁年龄组人群患病率增幅最大(33.2%)。男性死亡数和DALYs数均呈现上升的趋势,变化率分别为13.6%和2.2%。2016年,年龄标化DALY率排名前五位的省份为青海省(314.6/10万)、贵州省(303.1/10万)、云南省(262.4/10万)、广西壮族自治区(239.6/10万)和台湾省(227.2/10万)。结论 1990-2016年,我国乙型肝炎引起的肝硬化及其他慢性肝病患病情况呈现上升趋势,重点为男性和15~49岁年龄组的人群,不同省份疾病负担情况分布不均,防治工作依然不容忽视。
英文摘要:
      Objective The aim of this study was to analyze the disease burden of cirrhosis and other chronic liver diseases caused by hepatitis B in China, from 1990 to 2016, and to provide evidence for the development of related strategies. Methods Data were collected from the results of the Global Burden of Disease Study 2016 (GBD2016). We analyzed the current epidemiological patterns by calculating the prevalence, mortality, and disability adjusted life year (DALY) of cirrhosis and other chronic liver diseases, caused by hepatitis B during 1990 and 2016 in China. Results Compared with data from 1990, the number of patients and deaths with cirrhosis and other chronic liver diseases caused by hepatitis B in 2016 increased by 79.6% and 2.4%, respectively. The prevalence increased by 49.2%, higher (50.3%) in males than that (42.3%) in females. Compared with other age groups, the increase (33.2%) of prevalence appeared the fastest, in the 15-49 age group. In males, the number of deaths and DALYs increased by 13.6% and 2.2%, respectively. In 2016, the five top provinces on age-standardized DALY rates, appeared as Qinghai (314.6 per 100 000), Guizhou (303.1 per 100 000), Yunnan (262.4 per 100 000), Guangxi Zhuang Autonomous Region (239.6 per 100 000) and Taiwan (227.2 per 100 000). Conclusions From 1990 to 2016, the prevalence rates of hepatitis B related cirrhosis and other chronic liver diseases showed an upward trend, particularly in males and in people aged 15 to 49 years old, in China. However, the disease burden of different provinces was unevenly distributed. Based on our findings, we suggested that strategies that related to prevention and management of hepatitis B caused cirrhosis and other chronic liver diseases should be paid more attention to.
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