| 刘莉,张卿,高鹰,郭芳菲,李思诺,张蕊,牛凯军.生活方式与抑郁症状的关联性研究：TCLSIH研究[J].中华流行病学杂志,2020,41(10):1674-1680 |
| 生活方式与抑郁症状的关联性研究：TCLSIH研究 |
| Study on the relationship between lifestyle and depression symptoms: a TCLSIH study |
| 收稿日期:2020-03-02 出版日期:2020-10-27 |
| DOI：10.3760/cma.j.cn112338-20200302-00227 |
| 中文关键词: 抑郁症状 生活方式 |
| 英文关键词: Depression symptom Lifestyle |
| 基金项目: |
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| 摘要点击次数: 3157 |
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| 中文摘要: |
| 目的 选取2013－2016年天津慢性低度炎症与健康（TCLSIH）队列人群为研究对象，探讨生活方式各因素与抑郁症状的关系，为开展生活方式干预和防治抑郁症提供参考依据。方法 采用横断面研究，对24 256名研究对象进行抑郁自评量表（SDS）评估抑郁症状、生活方式调查问卷以及体格检查。采用SAS 9.3软件，将SDS评分按总分<45和≥45分为无抑郁症状组和抑郁症状组，分析生活方式各因素与抑郁症状的关系。结果 研究对象中SDS≥45分占16.59%。基线调查显示：与无抑郁症状组人群相比，抑郁症状组人群有较高中性粒细胞计数与淋巴细胞计数比（NLR）水平（P<0.01）、有较低的BMI、总能量摄入和身体活动量（P<0.000 1）；并倾向于少吃植物性膳食模式、较多的食用动物性食物膳食模式及甜食和水果膳食模式（P<0.000 1）。抑郁症状组人群中吸烟者的比例较高、偶尔饮酒者比例较低（P<0.01）；有较多的女性、独居者、文化程度低、家庭月总收入低；每日室外时间>5 h者比例较高；而管理人员、已婚者和喜欢与亲友来往者比例较低。logistic回归多因素分析结果显示：男性、年龄、NLR、吸烟（OR=1.14，95% CI：1.03~1.26）、已戒酒状态、动物性食物膳食模式（OR=1.41，95% CI：1.35~1.46）、甜食和水果膳食模式（OR=1.17，95% CI：1.13~1.22）、睡眠时间>7.5 h/d、室外活动时长3~5 h/d、室外活动时长>5 h/d与抑郁症状呈正相关（P<0.05）；而BMI（OR=0.98，95% CI：0.97~0.99）、文化程度（OR=0.76，95% CI：0.70~0.82）、管理人员、家庭月总收入（OR=0.63，95% CI：0.58~0.68）、总能量摄入、身体活动量（OR=0.86，95% CI：0.84~0.89）、已婚状态、喜欢与亲友来往与抑郁症状呈负相关（P<0.05）。结论 生活方式各因素与抑郁症状密切相关，开展生活方式干预抑郁症将成为抑郁症防治的新途径。 |
| 英文摘要: |
| Objective To evaluate the relationship between lifestyle factors and depressive symptoms based on the TCLSIH cohort of 2013-2016 and provide evidence for the intervention on lifestyle in the prevention and treatment of depression in the future. Methods A cross-sectional study was conducted in 24 256 persons by using a self-rating depression scale (SDS) to assess the depressive symptoms, and lifestyle questionnaire survey and physical examination were carried out. By using software SAS 9.3. The study subjects were divided into two groups: non-depression group (SDS score<45) and depression group (SDS score≥45), and the relationship between lifestyle factors and depressive symptoms was analyzed. Results The study subjects in depression group accounted for 16.59%; the baseline survey showed that compared with non-depression group, the subjects in depression group had higher neutrophil count and lymphocyte count ratio (NLR), lower BMI, lower total energy intake, and lower physical activity level, and tended to take less plant food diet, more animal food diet and sweet food diet (P<0.000 1). In the depressive group, there were more smokers and less occasional drinkers (P<0.01), and there were more women, home-aloners, people with lower education levels, people with lower total household income, and less staff members, married and those who liked to contact relatives and friends, but the proportion of people who spent more than 5 hours daily for outdoor activities was higher. Multiple linear regression analysis results showed that being male, aged, NLR, smoking (OR=1.14, 95% CI: 1.03-1.26), quitting alcohol, being home-aloners, animal food diet (OR=1.41, 95% CI:1.35-1.46), sweet food diet (OR=1.17, 95% CI: 1.13-1.22), sleep time >7.5 h/d, outdoor activity time 3-5 h/d, outdoor activity time > 5 h/d were positively correlated with depression (P<0.05). BMI(OR=0.98, 95% CI: 0.97-0.99), education level (OR=0.76, 95% CI: 0.70-0.82), being staff member, total household income (OR=0.63, 95% CI: 0.58-0.68), total energy intake, physical activity (OR=0.86, 95% CI: 0.84-0.89), married status, move contacts with relatives or friends were negatively related with depression (P<0.05). Conclusion Lifestyle is closely related to the occurrence of depressive symptoms, and lifestyle intervention seems be a new way to prevent and treat depression. |
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