| 李敏娟,邵丹彤,陈茹,王少明,魏文强.具核梭杆菌与上消化道癌研究进展[J].中华流行病学杂志,2020,41(11):1938-1941 |
| 具核梭杆菌与上消化道癌研究进展 |
| Progress in research of Fusobacterium nucleatum and upper gastrointestinal cancer |
| 收稿日期:2019-11-02 出版日期:2020-11-25 |
| DOI：10.3760/cma.j.cn112338-20191102-00776 |
| 中文关键词: 具核梭杆菌 上消化道癌 癌前病变 |
| 英文关键词: Fusobacterium nucleatum Upper gastrointestinal cancer Precancerous lesions |
| 基金项目:国家重点研发计划（2016YFC0901400，404）；中国医学科学院医学与健康科技创新工程（协同创新团队项目）（2016-I2M-3-001）；北京协和医学院中央高校基本科研业务费专项资金（3332019139） |
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| 中文摘要: |
| 随着多组学以及高通量测序技术的发展，研究表明消化道菌群紊乱与多癌种的发生发展相关，但是关于上消化道癌及其癌前病变与消化道微生态相关性的研究尚处于起步阶段。具核梭杆菌，口腔共生菌之一，也是一种机会性致病菌，通过促进肿瘤微环境形成进而促进肿瘤进展，可作为新型生物标志物运用于肿瘤的早发现、早诊断和早治疗。本文通过检索中国知网、万方数据知识服务平台、PubMed和Embase数据库，对具核梭杆菌与上消化道癌及其癌前病变的研究现况进行总结，发现癌组织中具核梭杆菌的丰度较癌旁组织高且与不良预后相关，该菌种与癌前病变的研究亟待开展。此外，标本类型、检测方式、菌种亚型、致癌机制等多方向仍然有待探索。 |
| 英文摘要: |
| With the development of multi-omics and high throughput sequencing technology, studies have shown that the disorder of microbiota is related to various cancers. Nevertheless, the research on the relationship between upper digestive tract cancer or precancerous lesions and gastrointestinal microecology is still less. Fusobacterium nucleatum, one of the oral symbiotic bacteria, is also an opportunistic pathogen, which can promote the formation of tumor microenvironment and can be used as a new biomarker for the early detection and early diagnosis of cancer. In this study, by searching CNKI, Wanfang data, PubMed and Embase databases, it was found that the abundance of F. nucleatum in cancer tissues is higher than that in paracancerous tissues and associated with poor prognosis. The research of relationship between F. nucleatum and precancerous lesions needs to be carried out urgently. In addition, the types of specimens, sequencing technology, strain subtypes, carcinogenic mechanism and other directions still need to be explored. |
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