| 赵薛飞,叶硕,马瑞,董红军,方挺,许国章.宁波市2019年健康人群百日咳血清流行病学调查[J].中华流行病学杂志,2021,42(4):638-642 |
| 宁波市2019年健康人群百日咳血清流行病学调查 |
| Seroepidemiology of pertussis in healthy population in Ningbo, 2019 |
| 收稿日期:2020-06-29 出版日期:2021-04-22 |
| DOI：10.3760/cma.j.cn112338-20200629-00894 |
| 中文关键词: 百日咳 血清流行病学 感染 |
| 英文关键词: Pertussis Seroepidemiology Infection |
| 基金项目:宁波市医疗卫生品牌学科（PPXK2018-10）；浙江省医学重点学科（07-013） |
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| 中文摘要: |
| 目的 了解宁波市健康人群百日咳感染血清流行病学特征，评估人群百日咳实际感染水平。方法 采用横断面调查设计，分层随机抽取宁波市3个区（县）9个年龄组共1 206名健康居民纳入研究，采集调查对象血清并用ELISA法定量检测血清百日咳毒素IgG（PT-IgG）抗体。结果 调查对象PT-IgG抗体阳性率为0.91%（95%CI：0.45%~1.63%），抗体几何平均滴度（GMT）为3.10（95%CI：2.86~3.36）IU/ml。9个年龄组人群PT-IgG抗体阳性率在0.00%~1.68%之间，GMT在2.08~5.28 IU/ml之间。≥5岁人群百日咳评估感染率为4 572.81/10万（95%CI：1 807.30/10万~9 348.12/10万），感染率高峰出现在5~岁组和≥50岁组，分别为9 301.62/10万（95%CI：1 121.77/10万~33 154.68/10万）和8 967.02/10万（95%CI：1 059.45/10万~31 845.94/10万）。结论 2019年宁波市人群百日咳实际感染率较高。由于疫苗诱导产生的抗体并不持久，宁波市青少年和成年人已成为百日咳感染重点人群。建议强化百日咳监测能力，完善疫苗免疫策略。 |
| 英文摘要: |
| Objective To understand the seroepidemiological characteristics of pertussis in healthy population in Ningbo, and estimate the overall incidence of pertussis. Methods A cross-sectional survey method was used in this study. A total of 1 206 healthy residents in 9 age groups were stratified randomly selected from 3 counties of Ningbo. Serum samples were collected from the subjects, and the pertussis toxin immunoglobulin G antibody (PT-IgG) levels were measured quantitatively by enzyme-linked immunosorbent assay (ELISA). Results The mean PT-IgG seropositive rate in the subjects was 0.91% (95%CI:0.45%-1.63%) with a geometric mean titer (GMT) of 3.10 (95%CI:2.86-3.36) IU/ml. The seropositive rates ranged from 0.00% to 1.68%, and the GMTs ranged from 2.08 IU/ml to 5.28 IU/ml in 9 age groups. The incidence rate of pertussis was estimated to be 4 572.81 per 100 000 in age group ≥ 5 years (95%CI:1 807.30 per 100 000-9 348.12 per 100 000), and the peak of estimated incidence rates were found in age group 5-years (9 301.62 per 100 000, 95%CI:1 121.77 per 100 000-33 154.68 per 100 000) and age group ≥ 50 years old (8 967.02 per 100 000, 95%CI:1 059.45 per 100 000-31 845.94 per 100 000). Conclusions The actual incidence of pertussis was high in Ningbo in 2019. As a result of waning immunity after vaccination, pertussis can occur in adolescents and adults. The pertussis surveillance should be strengthened and the pertussis vaccination strategy should be improved. |
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