| 乔世杰,刘星,何纳.HIV感染者巨细胞病毒血症现患率Meta分析[J].中华流行病学杂志,2021,42(4):723-727 |
| HIV感染者巨细胞病毒血症现患率Meta分析 |
| Plasma cytomegalovirus viremia prevalence among HIV-infected individuals: a Meta-analysis |
| 收稿日期:2020-06-29 出版日期:2021-04-22 |
| DOI：10.3760/cma.j.cn112338-20200629-00899 |
| 中文关键词: 艾滋病病毒 巨细胞病毒血症 现患率 Meta分析 |
| 英文关键词: HIV Cytomegalovirus viremia Prevalence Meta-analysis |
| 基金项目:国家科技重大专项（2018ZX10721102-004） |
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| 中文摘要: |
| 目的 运用Meta分析了解HIV感染者巨细胞病毒（CMV）血症的流行情况及相关因素。方法 系统检索2011-2020年PubMed、中国知网、万方数据知识服务平台、维普数据库中关于HIV感染者CMV血症现患率的文献，文献筛选和数据提取后进行Meta分析。结果 共纳入15篇文献，总样本量为5 076例。Meta随机效应模型显示，HIV感染者CMV血症合并现患率为26.2%（95%CI：16.8%~35.6%，I2=99%）；亚组分析和Meta回归结果显示，不同研究间异质性来源可能为：研究样本中>30岁人群比例、同性性传播比例、HIV病毒载量>104拷贝数/ml比例、CD4+T淋巴细胞计数<200个/μl比例。结论 HIV感染者CMV血症现患率较高，现患CMV血症可能与HIV感染者的年龄、HIV感染途径、艾滋病病程进展密切相关。 |
| 英文摘要: |
| Objective To understand the prevalence and correlates of plasma cytomegalovirus (CMV) viremia among HIV-infected individuals by Meta-analysis. Methods A systematic literature retrieval was conducted by PubMed, CNKI, Wanfang, and VIP databases for the information about the prevalence of plasma CMV viremia among HIV-infected individuals published from 2011 to 2020. Meta-analysis was used to calculate the pooled prevalence after literature screening and data extraction. Results Fifteen studies were included, and the total sample size was 5 076. The random effect model showed that the pooled prevalence of CMV viremia among HIV-infected individuals was 26.2% (95%CI:16.8%-35.6%, I2=99%); Subgroup analysis and Meta-regression showed that the sources of heterogeneity among different studies were:the proportion of individuals aged >30 years in sample, the proportion of homosexual transmission in the sample, the proportion of individuals whose HIV viral load > 104 copies/ml, the proportion of individuals whose CD4+T lymphocyte counts <200 cells/μl. Conclusion Among HIV-infected individuals, the prevalence of CMV viremia was high and might be associated with age, HIV transmission mode, the status of HIV/AIDS. |
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