| 孟丹,宋丽,祁卓,王捷,刘虹,吕元婧,贾海霞,丁玲,郝敏,田志强,王金桃.高危型人乳头瘤病毒感染的转归特点及阴道微环境因子对其转归影响的研究[J].中华流行病学杂志,2021,42(6):1103-1107 |
| 高危型人乳头瘤病毒感染的转归特点及阴道微环境因子对其转归影响的研究 |
| Prognosis of high-risk HPV infection and its influences by vaginal micro-environmental factors |
| 收稿日期:2020-08-29 出版日期:2021-06-29 |
| DOI：10.3760/cma.j.cn112338-20200829-01107 |
| 中文关键词: 阴道微环境因子 高危型人乳头瘤病毒 转归 |
| 英文关键词: Vaginal micro-environmental factors High-risk human papillomavirus Prognosis |
| 基金项目:国家自然科学基金（81872705，81473060，81703313）；国家卫生和计划生育委员会公益性行业科研专项（201402010） |
| 作者 | 单位 | E-mail | | 孟丹 | 山西医科大学公共卫生学院流行病学教研室, 太原 030001 | | | 宋丽 | 山西医科大学公共卫生学院流行病学教研室, 太原 030001 | | | 祁卓 | 山西医科大学公共卫生学院流行病学教研室, 太原 030001 | | | 王捷 | 山西医科大学公共卫生学院流行病学教研室, 太原 030001 | | | 刘虹 | 山西医科大学公共卫生学院流行病学教研室, 太原 030001 | | | 吕元婧 | 山西医科大学公共卫生学院流行病学教研室, 太原 030001 | | | 贾海霞 | 山西医科大学公共卫生学院流行病学教研室, 太原 030001 | | | 丁玲 | 山西医科大学公共卫生学院流行病学教研室, 太原 030001 | | | 郝敏 | 山西医科大学第二医院妇产科, 太原 030001 | | | 田志强 | 山西医科大学口腔医院, 太原 030001 | | | 王金桃 | 山西医科大学公共卫生学院流行病学教研室, 太原 030001 | wangjt59@163.com |
|
| 摘要点击次数: 1803 |
| 全文下载次数: 544 |
| 中文摘要: |
| 目的 探讨高危型人乳头瘤病毒（HR-HPV）感染的转归特点及阴道微环境因子对其转归的影响。方法 从本课题组前期建立的社区队列中，选取HR-HPV感染、经病理学诊断为正常宫颈的421名女性为研究对象，进行24个月的随访。在收集基线资料的基础上，应用需氧菌性阴道炎/细菌性阴道病联合检测试剂盒测定阴道微环境因子，采用导流杂交技术检测HPV感染状况。根据基线和随访24个月后HR-HPV的感染状况，描述HR-HPV感染的转归特征，并探讨阴道微环境因子对HR-HPV感染转归的影响。结果 在390名完成24个月随访的HR-HPV感染女性中，HR-HPV持续感染率居前5位的型别依次为HPV16（24.1%）、HPV58（22.2%）、HPV53（21.7%）、HPV52（20.0%）和HPV39（11.8%）。阴道pH值（aOR=1.74，95%CI：1.08~2.80）、唾液酸苷酶（aOR=2.70，95%CI：1.52~4.83）和白细胞酯酶（aOR=3.41，95%CI：2.13~5.44）异常可增加HR-HPV持续感染的风险，其中唾液酸苷酶和白细胞酯酶异常均可增加同型和异型HR-HPV持续感染的风险。结论 HPV16容易发生持续感染，阴道pH值、唾液酸苷酶和白细胞酯酶异常可增加HR-HPV持续感染的风险，特别是唾液酸苷酶、白细胞酯酶异常作用更为明显。 |
| 英文摘要: |
| Objective To describe the characteristics of high-risk human papillomavirus (HR-HPV) infection and its influences by vaginal micro-environmental factors. Methods A total of 421 women with HR-HPV infection and normal cervix diagnosed by pathology were selected from a community cohort established earlier by our research group for a 24-month follow-up. The baseline data were collected at enrollment. The vaginal micro-environmental factors were detected by using the combined detection kit of aerobic vaginitis and bacterial vaginosis. And the HPV was detected by using the flow-through hybridization technology. According to the HR-HPV infection status in baseline and 24 months of follow-up, with the prognosis characteristics of HR-HPV infection described, the impact of vaginal micro-environmental factors on the prognosis of HR-HPV infection was explored as well. Results Among 390 HR-HPV infected women who completed 24 months of follow-up, the top five types of persistent HR-HPV infection rate appeared as HPV16 (24.1%), HPV58 (22.2%), HPV53 (21.7%), HPV52 (20.0%), and HPV39 (11.8%), respectively. The results showed that women with abnormal vaginal pH (aOR=1.74, 95%CI:1.08-2.80), abnormal neuraminidase (aOR=2.70, 95%CI:1.52-4.83), or abnormal leucocyte esterase (aOR=3.41, 95%CI:2.13-5.44), the risk of HR-HPV persistent infection increased. The abnormalities of neuraminidase and leukocyte esterase could increase the risk of persistent infection of homotype and heterotypic HR-HPV. Conclusions HPV16 was prone to persistent infection. Abnormalities of vaginal pH, neuraminidase, and leukocyte esterase might increase the risk of HR-HPV persistent infection. Both the abnormalities of neuraminidase and leukocyte esterase play an essential role in the HR-HPV persistent infection. |
|
查看全文
Html全文
查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
|
|
|
