| 胡序怀,孟璐,高永祥,满塞丽麦,马圆,金成,王波,宁毅,李立明.深圳地区某女性体检人群人乳头瘤病毒感染现状及宫颈细胞学异常研究[J].中华流行病学杂志,2021,42(7):1205-1212 |
| 深圳地区某女性体检人群人乳头瘤病毒感染现状及宫颈细胞学异常研究 |
| Characteristics of human papillomavirus infection and abnormal cervical cytology in health check-up females in Shenzhen |
| 收稿日期:2021-01-06 出版日期:2021-07-29 |
| DOI：10.3760/cma.j.cn112338-20210106-00007 |
| 中文关键词: 人乳头瘤病毒 宫颈细胞学异常 宫颈液基薄层细胞学检查 高危人乳头瘤病毒 人乳头瘤病毒疫苗 |
| 英文关键词: Human papillomavirus Abnormal cervical cytology Thinprep cytologic test High-risk human papillomavirus Human papillomavirus vaccine |
| 基金项目:国家自然科学基金（91846303）；国家重点研发计划（2020YFC2003400） |
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| 中文摘要: |
| 目的 利用深圳地区女性体检人群数据，了解人群HPV感染及宫颈液基薄层细胞学检查（TCT）异常情况。方法 采用横断面研究设计，利用2018年深圳地区女性体检人群HPV感染及TCT数据，描述和分析HPV感染及TCT检测结果。结果 共有75 754名≥ 18岁女性纳入HPV感染率分析、103 508名≥ 18岁女性纳入TCT分析、69 964名≥ 18岁女性纳入2项检查的联合分析。HPV标化感染率为19.89%（95%CI：19.45%~20.33%），在年龄分布上呈现"U"形趋势。人群HPV主要流行的型别为HPV52、HPV51、HPV16、HPV58、HPV53。高危型HPV（17种）标化感染率高于低危型HPV（6种），单一HPV标化感染率高于与其他型别混合感染的多种型别HPV标化感染率。总宫颈细胞学的标化异常检出率为7.48%（95%CI：7.22%~7.75%），各类别分别为非典型鳞状上皮细胞4.58%（95%CI：4.40%~4.76%）、低度鳞状上皮内病变2.54%（95%CI：2.40%~2.69%）、高度鳞状上皮内病变0.27%（0.23%~0.31%）。HPV总感染率和各型别HPV感染率均有随着宫颈细胞学改变严重程度提高而升高的整体趋势。各类宫颈细胞学异常的检测结果中，主要流行型别为HPV52、HPV58、HPV16等。结论 本研究提示深圳地区HPV感染仍处在较高水平。应重视在人群层面开展HPV的筛查工作，尤其是在年轻及绝经前后女性人群中的筛查；加强对重点特殊人群（高危型别、易持续感染人群）的管理和进行宫颈细胞学筛查。同时提示在进行HPV疫苗的接种预防工作时，需参考流行的HPV型别。 |
| 英文摘要: |
| Objective To describe the characteristics of human papillomavirus infection and thinprep cytologic test (TCT) outcome in health check-up females in Shenzhen. Methods Use cross-sectional design, collect information from data from health check-up females in Shenzhen and describe characteristics of HPV infections screening and TCT outcomes. Results We collected the data of 75 754 females, 103 508 females and 69 964 females received HPV detection, TCT and combined detection respectively. HPV standardized infection rate was 19.89% (95%CI:19.45%-20.33%) and showed a "U-shaped" pattern in age distribution. The most prevalent HPV genotypes were 52, 51, 16, 58 and 53. Infection rate was higher for high-risk HPV than low-risk HPV genotype. Single infection was more common than its multiple infection. In addition, 7.48% (95%CI:7.22%-7.75%) women were TCT positive, of whom 4.58% (95%CI:4.40%-4.76%), 2.54% (2.40%-2.69%), 0.27% (95%CI:0.23%-0.31%) had atypical squamous cells, low-grade squamous intraepithelial lesions and high-grade squamous intraepithelial lesions, respectively. Overall and subtype HPV infection rates increased with severity of abnormal cervical cytology. The most prevalent HPV genotypes were 52, 58 and 16 in women with abnormal cervical cytology.Conclusions HPV prevalence remains at a high level in Shenzhen. This study suggests that attention should be paid to HPV screening, especially in young, perimenopausal women and in high risk HPV genotype infection. Timely follow-up and cervical cytology screening are required for women with high-risk HPV infection or persistent infection. Future vaccination strategies should take account of prevalent HPV genotype. |
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