文章摘要
李娟,魏明伟,朱凤才.乙型肝炎疫苗免疫无/低应答影响因素的研究进展[J].中华流行病学杂志,2021,42(11):2066-2070
乙型肝炎疫苗免疫无/低应答影响因素的研究进展
Progress in research of influential factors for non- or low-immune response to hepatitis B vaccination
收稿日期:2020-09-10  出版日期:2021-11-20
DOI:10.3760/cma.j.cn112338-20200910-01145
中文关键词: 乙肝疫苗;无/低应答;影响因素
英文关键词: Hepatitis B vaccine;Non/low-response;Influential factors
基金项目:
作者单位E-mail
李娟 南京医科大学公共卫生学院 211166  
魏明伟 江苏省疾病预防控制中心疫苗临床评价所, 南京 210009  
朱凤才 南京医科大学公共卫生学院 211166
江苏省疾病预防控制中心疫苗临床评价所, 南京 210009
江苏省疾病预防控制中心国家卫生健康委员会肠道病原微生物重点实验室/南京医科大学全球健康中心, 南京 211166 
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中文摘要:
      HBV使感染者罹患多种乙肝相关性疾病,且目前尚无治疗的特效药。我国人口基数大,现存感染者多,因此乙肝疫苗的预防接种在该病的预防控制中就显得尤为重要。但是,部分接种者在按照推荐的乙肝疫苗免疫程序接种后,并不能产生有效的保护性免疫应答。本综述旨在从机体、疫苗两个方面分析接种乙肝疫苗后无/低免疫应答的影响因素,探讨无/低免疫应答机制,从而对我国乙肝的防治提供科学依据。
英文摘要:
      Hepatitis B virus (HBV) can cause a variety of hepatitis B-related diseases in infected people, and there is no specific drug for treatment. China, with a large population base, is the country with the heaviest burden of HBV infection in the world. Therefore, hepatitis B vaccination is particularly important in the prevention and control of this disease. However, some vaccinees did not produce effective protective immune response after vaccination according to the recommended hepatitis B vaccine immunization schedule. The purpose of this review is to analyze the influential factors of non/low immune response after hepatitis B vaccination from the aspects of organism and vaccine, and explore the mechanism of non/low immune response, so as to provide scientific basis for the prevention and treatment of hepatitis B in China.
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