| 李娟,魏明伟,朱凤才.乙型肝炎疫苗免疫无/低应答影响因素的研究进展[J].中华流行病学杂志,2021,42(11):2066-2070 |
| 乙型肝炎疫苗免疫无/低应答影响因素的研究进展 |
| Progress in research of influential factors for non- or low-immune response to hepatitis B vaccination |
| 收稿日期:2020-09-10 出版日期:2021-11-20 |
| DOI：10.3760/cma.j.cn112338-20200910-01145 |
| 中文关键词: 乙肝疫苗 无/低应答 影响因素 |
| 英文关键词: Hepatitis B vaccine Non/low-response Influential factors |
| 基金项目: |
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| 中文摘要: |
| HBV使感染者罹患多种乙肝相关性疾病，且目前尚无治疗的特效药。我国人口基数大，现存感染者多，因此乙肝疫苗的预防接种在该病的预防控制中就显得尤为重要。但是，部分接种者在按照推荐的乙肝疫苗免疫程序接种后，并不能产生有效的保护性免疫应答。本综述旨在从机体、疫苗两个方面分析接种乙肝疫苗后无/低免疫应答的影响因素，探讨无/低免疫应答机制，从而对我国乙肝的防治提供科学依据。 |
| 英文摘要: |
| Hepatitis B virus (HBV) can cause a variety of hepatitis B-related diseases in infected people, and there is no specific drug for treatment. China, with a large population base, is the country with the heaviest burden of HBV infection in the world. Therefore, hepatitis B vaccination is particularly important in the prevention and control of this disease. However, some vaccinees did not produce effective protective immune response after vaccination according to the recommended hepatitis B vaccine immunization schedule. The purpose of this review is to analyze the influential factors of non/low immune response after hepatitis B vaccination from the aspects of organism and vaccine, and explore the mechanism of non/low immune response, so as to provide scientific basis for the prevention and treatment of hepatitis B in China. |
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