文章摘要
黄瑛,贾蕾,田祎,吕冰,曲梅,张新,刘白薇,霍达,吴晓娜,严寒秋,杨鹏.2015-2021年北京市霍乱弧菌病原学和流行特征分析[J].中华流行病学杂志,2022,43(5):734-738
2015-2021年北京市霍乱弧菌病原学和流行特征分析
Etiological and epidemiological characteristics ofVibrio cholerae in Beijing, 2015-2021
收稿日期:2022-01-23  出版日期:2022-05-13
DOI:10.3760/cma.j.cn112338-20220123-00064
中文关键词: 霍乱弧菌;血清型;毒力基因;脉冲场凝胶电泳;流行特征
英文关键词: Vibrio cholerae;Serotype;Virulence gene;Pulsed field gel electrophoresis;Epidemiological characteristics
基金项目:科技重大专项(2018ZX10714002-003-002)
作者单位E-mail
黄瑛 北京市疾病预防控制中心传染病地方病预防控制所, 食物中毒诊断溯源技术北京市重点实验室, 北京 100013  
贾蕾 北京市疾病预防控制中心传染病地方病预防控制所, 食物中毒诊断溯源技术北京市重点实验室, 北京 100013  
田祎 北京市疾病预防控制中心传染病地方病预防控制所, 食物中毒诊断溯源技术北京市重点实验室, 北京 100013  
吕冰 北京市疾病预防控制中心传染病地方病预防控制所, 食物中毒诊断溯源技术北京市重点实验室, 北京 100013  
曲梅 北京市疾病预防控制中心传染病地方病预防控制所, 食物中毒诊断溯源技术北京市重点实验室, 北京 100013  
张新 北京市疾病预防控制中心传染病地方病预防控制所, 食物中毒诊断溯源技术北京市重点实验室, 北京 100013  
刘白薇 北京市疾病预防控制中心传染病地方病预防控制所, 食物中毒诊断溯源技术北京市重点实验室, 北京 100013  
霍达 北京市疾病预防控制中心传染病地方病预防控制所, 食物中毒诊断溯源技术北京市重点实验室, 北京 100013  
吴晓娜 北京市疾病预防控制中心传染病地方病预防控制所, 食物中毒诊断溯源技术北京市重点实验室, 北京 100013  
严寒秋 北京市疾病预防控制中心传染病地方病预防控制所, 食物中毒诊断溯源技术北京市重点实验室, 北京 100013 13671113791@163.com 
杨鹏 北京市疾病预防控制中心传染病地方病预防控制所, 食物中毒诊断溯源技术北京市重点实验室, 北京 100013  
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中文摘要:
      目的 分析2015-2021年北京市霍乱弧菌的病原学和流行特征,为霍乱防控提供参考。方法 对北京市2015-2021年分离到的霍乱弧菌,进行血清分型、毒力基因检测和PFGE实验;对收集的霍乱病例流行病学和临床资料,用描述性流行病学方法分析其流行特征。结果 北京市2015-2021年共分离76株O1群霍乱弧菌(来源分别为人源性61株、环境涂抹10株和水产品5株),包括68株小川型菌株和8株稻叶型菌株,其中6株为O1群小川型菌株ctxAB基因阳性,均分离自散发病例。PFGE结果显示,76株分为33种带型。北京市2015-2021年共报告霍乱疫情38起,以散发疫情为主(92.11%,35/38);累计报告病例45例,6-9月占97.78%(44/45)。北京市有9个行政区报告霍乱病例,朝阳区和昌平区分别占42.22%(19/45)和31.11%(14/45);霍乱病例的年龄分布在19~63岁,44例病例均出现腹泻症状,1例临床症状不详。腹泻次数为3~9次/d的占84.09%(37/44)。临床症状中,出现黄色稀水样便、腹痛、恶心/呕吐和发热的分别占95.45%(42/44)、68.18%(30/44)、40.91%(18/44)和36.36%(16/44)。结论 2015-2021年北京市分离到的霍乱弧菌以O1群小川型为主,PFGE带型多样;北京市有9个行政区报告霍乱疫情,以散发为主,6-9月为疫情高峰。
英文摘要:
      Objective To analyze the etiological and epidemiological characteristics of Vibrio cholerae in Beijing during 2015-2021 and provide evidence for the prevention and control of cholera. Methods The V. cholerae strains isolated in Beijing during 2015-2021 were analyzed by serotyping and virulence genes detection. Pulsed field gel electrophoresis (PFGE) was performed for the molecular typing of the strains. Based on the collected epidemiological and clinical data of cholera cases,the epidemiological characteristics of cholera were analyzed by descriptive epidemiology method. Results A total of 76 Vibrio cholerae O1 strains were isolated in Beijing during 2015-2021, including 61 strains from human, 10 strains from environment and 5 strains from seafood. The 76 strains consisted of 68 Ogawa strains and 8 Inaba strains. Six Ogawa strains isolated from sporadic cases carried ctxAB. After NotⅠ digestion, 76 strains were divided into 33 PFGE patterns. From 2015 to 2021, a total of 38 cholera epidemics were reported in Beijing, most of them were sporadic ones, accounting for 92.11% (35/38). A total of 45 cases were reported, and the cases occurred during June-September accounted for 97.78% (44/45). Cholera cases occurred in 9 districts of Beijing, and the cases reported in Chaoyang district accounted for 42.22% (19/45) and in Changping district accounted for 31.11% (14/45). The age of the cholera cases ranged from 19 to 63 years. Except for one case with unknown clinical symptoms, 44 cases had diarrhea symptoms with 84.09% (37/44) of the cases reporting diarrhea (3-9 times/day), followed by yellow watery stool (95.45%, 42/44), abdominal pain (68.18%, 30/44), nausea and vomiting (40.91%, 18/44) and fever (36.36%, 16/44). Conclusion Vibrio cholerae strains isolated in Beijing during 2015-2021 were mainly O1 serotype Ogawa,most of which were non-toxigenic. The PFGE of the strains varied. Cholera epidemics occurred in 9 districts of Beijing, but most were sporadic ones with incidence peak during June-September.
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