文章摘要
褚衍茹,张言武,雷松,陈奕,张栋梁,顾晓敏,劳旭影,王海波,沈贤东,胡群雄,易波,陈恩富,许国章.新型冠状病毒感染者末次核酸阴性前后的传染性分析[J].中华流行病学杂志,2022,43(6):841-845
新型冠状病毒感染者末次核酸阴性前后的传染性分析
Analysis on infectivity of COVID-19 patients before and after last negative nucleic acid test
收稿日期:2022-03-01  出版日期:2022-06-16
DOI:10.3760/cma.j.cn112338-20220301-00164
中文关键词: 新型冠状病毒;核酸检测;传染性
英文关键词: 2019-nCoV;Nucleic acid testing;Infectivity
基金项目:宁波市科技重大专项-新型冠状病毒肺炎疫情防控应急科技攻关项目(2020C50001);宁波市“科技创新2025”重大专项(2021Z021);宁波市医疗卫生品牌学科(PPXK2018-10); 宁波市应急科技攻关重大专项(2022Z034)
作者单位E-mail
褚衍茹 宁波市疾病预防控制中心, 宁波 315010  
张言武 宁波市疾病预防控制中心, 宁波 315010  
雷松 宁波市疾病预防控制中心, 宁波 315010  
陈奕 宁波市疾病预防控制中心, 宁波 315010  
张栋梁 宁波市疾病预防控制中心, 宁波 315010  
顾晓敏 宁波市疾病预防控制中心, 宁波 315010  
劳旭影 宁波市疾病预防控制中心, 宁波 315010  
王海波 宁波市疾病预防控制中心, 宁波 315010  
沈贤东 宁波市镇海区疾病预防控制中心, 宁波 315200  
胡群雄 宁波市北仑区疾病预防控制中心, 宁波 315800  
易波 宁波市疾病预防控制中心, 宁波 315010  
陈恩富 浙江省疾病预防控制中心, 杭州 310051 enfchen@cdc.zj.cn 
许国章 宁波市疾病预防控制中心, 宁波 315010 xugz@nbcdc.org.cn 
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中文摘要:
      目的 研究新型冠状病毒(新冠病毒)感染者末次核酸阴性前后密切接触者(密接)的感染率,评估动态核酸检测结果在判断新冠病毒感染者传染性中的作用。方法 采用回顾性队列研究的方法,收集新冠病毒感染者的动态核酸检测结果。选择新冠病毒感染者在首次核酸检测阳性前有核酸阴性结果者为研究对象,对感染者的密接以及密接的密接(次密接)进行持续隔离医学观察,评估密接和次密接的发病风险。结果 共纳入宁波市2起本土疫情的89例新冠病毒感染者,均为确诊病例。追踪调查了5 609名密接,密接的总感染率为0.20%。感染者末次核酸阴性前的密接无感染,末次核酸阴性后的密接感染率为1.33%,且均为与指示病例共同居住生活者。感染者涉及的所有次密接均未感染。结论 新冠病毒感染者末次核酸阴性前无传染性,末次核酸阴性后开始具有传染性。
英文摘要:
      Objective To investigate the infection rate in close contacts of COVID-19 patients before and after the last negative nucleic acid test, evaluate the effect of dynamic nucleic acid test in determining the infectivity of COVID-19 patients. Methods Dynamic nucleic acid test results of COVID-19 cases were collected in a retrospective cohort study. COVID-19 cases with negative nucleic acid test results before their first positive nucleic acid tests were selected as study subjects. Close contacts of the index cases and the secondary close contacts were kept isolation for medical observation to assess their risk of infection. Results This study included 89 confirmed cases from two local COVID-19 epidemics in Ningbo. A total of 5 609 close contacts were surveyed, the overall infection rate was 0.20%. No close contacts of the COVID-19 cases before the last negative nucleic acid test were infected, and the infection rate in the close contacts of the COVID-19 cases after the last negative nucleic acid test was 1.33%, all of these close contacts lived together with the index cases. No secondary close contacts were infected. Conclusion COVID-19 patient becomes infectious after the last nucleic acid is negative, and has no infectivity before the last nucleic acid negative.
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