文章摘要
张楠,张爽,王锋,尹遵栋,苏秋东,张国民,缪宁,毕胜利,王富珍,沈立萍.我国2015-2017年急性乙型肝炎病例HBV基因型分布特征分析[J].中华流行病学杂志,2022,43(6):865-870
我国2015-2017年急性乙型肝炎病例HBV基因型分布特征分析
Epidemiological distribution of hepatitis B virus genotypes in acute hepatitis B cases in China,2015-2017
收稿日期:2021-12-30  出版日期:2022-06-16
DOI:10.3760/cma.j.cn112338-20211230-01041
中文关键词: 急性乙型肝炎;乙型肝炎病毒;基因型;分子流行病学
英文关键词: Acute Hepatitis B;Hepatitis B virus;Genotype;Molecular epidemiology
基金项目:国家科技重大专项(2017ZX10105015-001-002)
作者单位E-mail
张楠 中国疾病预防控制中心病毒病预防控制所, 北京 102206  
张爽 中国疾病预防控制中心病毒病预防控制所, 北京 102206  
王锋 中国疾病预防控制中心病毒病预防控制所, 北京 102206  
尹遵栋 中国疾病预防控制中心免疫规划中心, 北京 100050  
苏秋东 中国疾病预防控制中心病毒病预防控制所, 北京 102206  
张国民 中国疾病预防控制中心免疫规划中心, 北京 100050  
缪宁 中国疾病预防控制中心免疫规划中心, 北京 100050  
毕胜利 中国疾病预防控制中心病毒病预防控制所, 北京 102206  
王富珍 中国疾病预防控制中心免疫规划中心, 北京 100050 wangfz@chinacdc.cn 
沈立萍 中国疾病预防控制中心病毒病预防控制所, 北京 102206 shenlp@ivdc.chinacdc.cn 
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中文摘要:
      目的 分析我国急性乙型肝炎(乙肝)病例HBV基因型流行病学分布特征。方法 收集2015-2017年中国疾病预防控制信息系统报告的急性乙肝病例620例,通过巢式PCR扩增获得全长HBV基因组,构建系统发育树确定HBV基因型,结合基础资料分析HBV基因型的分布情况。结果 在620例急性乙肝病例中,成功分型519例(83.71%,519/620),包括A型(0.19%,1/519)、B型(27.17%,141/519)、C型(62.04%,322/519)、D型(9.06%,47/519)、I型(0.77%,4/519)和CD重组型(0.77%,4/519);2个主要的基因亚型为B2(95.03%,134/141)和C2(72.67%,234/322)。基因型在我国7个地区分布不同,C型在东北(94.55%,52/55)、华北(93.85%,61/65)、华东(78.87%,56/71)和华南地区(58.14%,50/86)的比例较高,B型在华中(58.07%,36/62)和西南(52.94%,45/85)地区的比例较高,西北地区的D型(48.42%,46/95)比例较高;共有515例成功获得血清型,包括adr(57.48%,296/515)、adw(30.87%,159/515)、ayr(0.19%,1/515)、ayw(11.46%,59/515)。B型以adw血清型(92.14%,129/140)为主,C型以adr血清型(91.88%,294/320)为主,D型均为ayw血清型;不同性别、年龄组中,基因型分布差异无统计学意义(P>0.05)。结论 2015-2017年我国急性乙肝基因型以B、C和D型为主,东北、华北、华东和华南地区C型为主;华中、西南地区B、C型均有,B型为主,D型多分布于西北地区;急性乙肝基因型与血清型存在相关性,B型以adw血清型为主,C型以adr血清型为主,D型均为ayw血清型;不同性别和年龄组中急性乙肝基因型分布无差异。
英文摘要:
      Objective To analyze the genotype distribution of acute hepatitis B virus in China. Methods A total of six hundred and twenty acute Hepatitis B cases reported to China Information System for Diseases Control and Prevention from 2015 to 2017 were selected. First, the full-length HBV genome was obtained by nested PCR amplification. In addition, the HBV genotype was determined by constructing a phylogeny tree. Finally, using primarydata, HBV genotype distribution was analyzed. Results A total of 519 (83.71%, 519/620) sequences were obtained genotype of 620 acute hepatitis B cases, including A (0.19%, 1/519), B (27.17%, 141/519), C (62.04%, 322/519), D (9.06%, 47/519), I (0.77%, 4/519) and C/D (0.77%, 4/519); B2(95.03%, 134/141) and C2 (72.67%, 234/322) were the two major subgenotypes. Genotypes were distributed differently in seven regions of China. The proportion of genotype C appeared higher in Northeast China (94.55%, 52/55), North China (93.85%, 61/65), East China (78.87%, 56/71), and South China (58.14%, 50/86). The proportion of genotype B was higher in Central China (58.07%, 36/62) and Southwest China (52.94%, 45/85), the proportion of genotype D was the highest in Northwest China (48.42%, 46/95). A total of 515 cases were classified as serotypes, including 'adr' (57.48%, 296/515), 'adw' (30.87%, 159/515), 'ayr' (0.19%, 1/515), and 'ayw' (11.46%, 59/515). Genotype B was dominated by 'adw' serotype (92.14%, 129/140), genotype C was dominated by 'adr' serotype (91.88%, 294/320),all genotype D were 'ayw' serotype. The genotype of acute hepatitis B was correlated with serotype, 'adw' was dominant in genotype B, 'adr' was dominant in genotype C and 'ayw' was dominant in genotype D.In different gender and age group, there was no statistical significance ingenotype distribution (P>0.05). Conclusions The genotype of acute hepatitis B in China from 2015 to 2017 was mainly B, C, and D; genotype C was dominant in the Northeast China,North China, East China and South China; B and C were common in Central and Southwest China, and genotype B was dominant. Genotype D was primarily distributed in Northwest China. The genotype of acute hepatitis B was correlated with serotype, 'adw' was dominant in genotype B, 'adr' was dominant in genotype C and 'ayw' was dominant in genotype D. There was no difference in the distribution of acute hepatitis B genotypes among different genders and age groups.
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