| 李志康,朱洋,杨潇,陈晓婷,顾菁,郝元涛,曹望楠,李菁华.成都市男男性行为人群3种类型HIV暴露前预防用药使用意愿及影响因素分析[J].中华流行病学杂志,2022,43(10):1658-1665 |
| 成都市男男性行为人群3种类型HIV暴露前预防用药使用意愿及影响因素分析 |
| Willingness to use the three types of pre-exposure prophylaxis and associated factors among men who have sex with men in Chengdu |
| 收稿日期:2022-05-01 出版日期:2022-10-18 |
| DOI：10.3760/cma.j.cn112338-20220501-00367 |
| 中文关键词: 暴露前预防用药 男男性行为人群 艾滋病 污名 |
| 英文关键词: Pre-exposure prophylaxis Men who have sex with men HIV Stigma |
| 基金项目:国家自然科学基金（81803334）；国家科技重大专项（2018ZX10715004） |
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| 中文摘要: |
| 目的 调查成都市MSM对3种类型HIV暴露前预防用药（PrEP）的使用意愿及影响因素。方法 2021年11月至2022年1月，依靠成都同乐健康咨询服务中心招募793名研究对象。收集社会人口学特征、最近6个月性行为发生情况、PrEP污名、HIV预期污名、MSM内化污名和3种类型PrEP的使用意愿。采用单因素和多因素logistic回归模型分析3种类型PrEP使用意愿的影响因素。结果 在793名研究对象中，按需口服药物的使用意愿较高（68.3%）。较高文化程度和多性伴均会促进口服类PrEP的使用意愿，较高文化程度[与初中及以下相比，高中/中专（aOR=2.43，95%CI：1.13~5.21）、大专（aOR=2.67，95%CI：1.27~5.61）、大学本科（aOR=3.21，95%CI：1.52~6.74）、硕士研究生及以上（aOR=3.77，95%CI：1.54~9.26）]、多性伴（aOR=1.54，95%CI：1.12~2.11）均与每天口服1粒药物呈正相关。较高的HIV预期污名对3种类型PrEP使用意愿均呈正相关：每天口服1粒药物（aOR=1.07，95%CI：1.02~1.12）、按需口服药物（aOR=1.09，95%CI：1.03~1.15）、每隔8周注射1次药物（aOR=1.06，95%CI：1.01~1.11）。结论 成都市MSM的PrEP整体使用意愿较高，推广PrEP有较高的可行性。未来应加强对该人群HIV和PrEP相关知识的宣传教育，提高认知水平，引导MSM树立正确的PrEP使用动机。 |
| 英文摘要: |
| Objective To investigate the willingness to use three types of pre-exposure prophylaxis (PrEP) and its associated factors among MSM in Chengdu.Methods A total of 793 MSM were recruited through Chengdu Tongle Health Consultation Service Centre between November 2021 to January 2022. Data were collected, including demographic characteristics, sexual behaviors in the last six months, PrEP-related stigma, HIV anticipated stigma, MSM internalized stigma, and willingness to use three types of PrEP. Univariate and multivariate logistic regression models were conducted to investigate the associated factors of willingness in using the three types of PrEP.Results Among 793 participants, willingness to take on-demand PrEP was higher (68.3%). Higher education and multiple sexual partners increased the willingness to use oral PrEP, higher education[compared with junior high school or below, high school or technical secondary school (aOR=2.43, 95%CI:1.13-5.21), junior college (aOR=2.67, 95%CI:1.27-5.61), bachelor degree (aOR=3.21, 95%CI:1.52-6.74), master degree or above (aOR=3.77, 95%CI:1.54-9.26)], multiple sexual partners (aOR=1.54, 95%CI:1.12-2.11) were positively associated with daily oral PrEP. HIV anticipated stigma was positively associated with the willingness in using all three types of PrEP:daily oral PrEP (aOR=1.07, 95%CI:1.02-1.12), on-demand PrEP (aOR=1.09, 95%CI:1.03-1.15), and injectable PrEP every 8 week (aOR=1.06, 95%CI:1.01-1.11).Conclusions The overall willingness in using PrEP in MSM in Chengdu is relatively high, and the promotion of PrEP is highly feasible. In the future, we should continue to promote publicity and education on HIV and PrEP-related knowledge in this population, improve the cognitive level, and guide MSM to establish the correct motivation for PrEP use. |
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