| 张海庆,王重建,刘晓田,罗丹,肖水源,杨汉东,张晓敏,邬堂春.华中区域常见慢性非传染性疾病前瞻性队列设计和建设概况[J].中华流行病学杂志,2023,44(1):34-39 |
| 华中区域常见慢性非传染性疾病前瞻性队列设计和建设概况 |
| Design and performance of a prospective cohort study of common chronic and non-communicable diseases in central China |
| 收稿日期:2022-09-21 出版日期:2023-01-14 |
| DOI：10.3760/cma.j.cn112338-20220921-00796 |
| 中文关键词: 自然人群 队列研究 慢性非传染性疾病 华中 |
| 英文关键词: General population Cohort study Chronic and non-communicable disease Central China |
| 基金项目:国家重点研发计划“精准医学研究”重点专项（2016YFC0900800） |
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| 中文摘要: |
| 随着我国经济的迅速发展、人口老龄化和城镇化进程的加剧，国民生活方式的改变，慢性非传染性疾病（慢性病）的流行现状非常严峻，但是其病因和发病机制仍不清楚，缺乏有效防治对策的科学依据，而队列研究是探索病因和发病机制的重要研究方法。因此，依托于2016年国家重点研发计划“精准医学研究”重点专项的大力支持，在我国3个省份（湖北、湖南和河南）启动了华中区域常见慢性病前瞻性队列研究（华中慢性病队列）的建设。完成了3个既独立又可整合的队列，共计115 424人的基线和107 252人的随访调查，其中3.9万人的东风-同济前瞻性队列完成了动态调查，包括问卷调查、体格检查、实验室指标检测以及血液和尿液生物样本收集。该队列对于阐明我国中部人群慢性病发生发展的病因和机制研究，对我国精准医学的建设有重要支撑作用和巨大贡献。本文对华中慢性病队列的设计理念、基本情况、主要成果、研究进展和挑战等进行了简要介绍。 |
| 英文摘要: |
| With the advance of the economy and population aging, the acceleration of urbanization and the change of people's lifestyles, the prevalence of chronic diseases has become very serious. However, the etiologies and pathogeneses of the diseases are not yet clear, and the evidence of effective prevention and treatment strategies is lacking. Cohort study is an important method for exploring etiology and pathogenesis. Therefore, based on the support of the Ministry of Science and Technology for precision medicine in 2016, we launched a prospective cohort study of common chronic and non-communicable diseases in three provinces (Hubei, Hunan and Henan) in central China. Three independent and integratable sub-cohorts consisting of 115 424 participants at baseline survey and 107 252 participants in follow up were established, including dynamic measurements in 39 000 subjects in Dongfeng-Tongji prospective cohort. Each participant was asked to complete a questionnaire survey, an anthropometric measurement, a laboratory measurement, and blood and urine samples were collected from them. The cohort study contributes greatly to elucidating the etiologies and pathogeneses of common chronic and non-communicable disease in Chinese population and the development of precision medicine in China. This paper briefly introduces the design concept, basic information, major achievements and progress, and challenges of the prospective cohort study of common chronic and non-communicable diseases in central China. |
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