文章摘要
刘杞梓,杨雪,薛珲,汤后林.男男性行为人群通过互联网获取HIV暴露前预防服务按需服药依从性及相关因素分析[J].中华流行病学杂志,2023,44(5):791-796
男男性行为人群通过互联网获取HIV暴露前预防服务按需服药依从性及相关因素分析
Analysis of on-demand adherence and related factors in men who have sex with men who access HIV pre-exposure prophylaxis services via the internet
收稿日期:2022-10-21  出版日期:2023-05-13
DOI:10.3760/cma.j.cn112338-20221021-00902
中文关键词: 艾滋病  男男性行为人群  暴露前预防  依从性
英文关键词: AIDS  Men who have sex with men  Pre-exposure prophylaxis  Compliancy
基金项目:国家自然科学基金(71874168)
作者单位E-mail
刘杞梓 中国疾病预防控制中心性病艾滋病预防控制中心流行病学室, 北京 102206  
杨雪 北京回龙观医院, 北京 100096  
薛珲 荷尔健康, 北京 100022  
汤后林 中国疾病预防控制中心性病艾滋病预防控制中心流行病学室, 北京 102206 tanghl@chinaaids.cn 
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中文摘要:
      目的 了解通过互联网获取HIV暴露前预防(PrEP)服务的MSM按需服药依从性及相关因素。方法 使用横断面研究样本量计算公式估计样本量为280人。2022年7月6日至8月30日利用荷尔健康平台招募研究对象,对该平台获取PrEP服务且服药方式为按需服药的MSM进行问卷调查,调查内容包括社会人口学特征、行为学特征、风险认知特征、PrEP知识和服药情况等信息。采用logistic回归分析MSM获取PrEP服务按需服药依从性的相关因素。结果 招募MSM 330人,问卷有效应答率为96.7%(319/330),年龄(32.5±7.3)岁,以大专/本科及以上文化程度(94.7%,302/319)、未婚(90.3%,288/319)、全职工作(95.9%,306/319)和月均收入≥10 000元(40.8%,130/319)为主。MSM按需服药依从性好的占86.5%(276/319)。logistic回归分析结果显示,相比于PrEP知识知晓情况差者,PrEP知识知晓情况好者按需服药依从性好(aOR=2.43,95%CI1.11~5.32)。结论 通过互联网获取PrEP服务的MSM按需服药的依从性总体较好,但仍需加强PrEP知识宣传,让更多的MSM愿意并正确使用PrEP药物,提高PrEP药物服用的依从性,减少该人群HIV感染风险。
英文摘要:
      Objective To understand the compliancy to on-demand HIV pre-exposure prophylaxis (PrEP) and related factors in men who have sex with men (MSM) accessing to PrEP service through an Internet platform. Methods A cross-sectional study method was used to recruit survey respondents through the Heer Health platform from July 6 to August 30, 2022, and a questionnaire survey on the current status of medication use was conducted in MSM who use PrEP through the platform and take medication on demand. The MSM's information collected in the survey mainly included socio-demographic characteristics, behavioral characteristics, risk perception characteristics, PrEP awareness and the status of dose taking. Univariate and multivariate logistic regression analyses were used to evaluate factors related with compliancy to PrEP. Results A total of 330 MSM who met the recruitment criteria were included during the survey period, with a valid response rate of 96.7% (319/330) to the questionnaire survey. The age of the 319 MSM was (32.5±7.3) years. Most of them had education level of junior college or college and above (94.7%, 302/319), most of them were unmarried (90.3%, 288/319), most of them had full-time works (95.9%, 306/319), and 40.8% of them had average monthly income ≥10 000 yuan (130/319). The proportion of the MSM with good compliancy to PrEP was 86.5% (276/319). The results of univariate and multivariate logistic analyses showed that the MSM with good awareness of PrEP had relatively better compliancy to PrEP compared with those with poor awareness of PrEP (aOR=2.43, 95%CI:1.11-5.32). Conclusions The compliancy to on-demand PrEP was good in MSM who accessed to the services through Internet platform, but there is still a need to strengthen PrEP promotion in MSM for the further improvement of PrEP compliancy and reduction of the risk for HIV infection in this population.
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