| 谭音希,彭和香,郑一,王斯悦,武轶群,秦雪英,李劲,吴涛,陈大方,王梦莹,胡永华.短期环境空气污染物暴露与动脉僵硬度的关联及肥胖的效应修饰作用分析[J].中华流行病学杂志,2024,45(12):1639-1648 |
| 短期环境空气污染物暴露与动脉僵硬度的关联及肥胖的效应修饰作用分析 |
| Association between short-term ambient air pollution exposure and arterial stiffness and effect modification of obesity |
| 收稿日期:2024-05-31 出版日期:2024-12-16 |
| DOI：10.3760/cma.j.cn112338-20240531-00320 |
| 中文关键词: 空气污染物 动脉硬化 交互作用 |
| 英文关键词: Air pollution Arterial stiffness Interaction |
| 基金项目:国家自然科学基金(82204135,81230066,81102177,82473716);北京市自然科学基金(7232237);中国疾病预防控制中心环境与人群健康重点实验室开放基金(2022-CKL-02) |
| 作者 | 单位 | E-mail | | 谭音希 | 北京大学公共卫生学院营养与食品卫生学系, 北京 100191 | | | 彭和香 | 北京大学公共卫生学院流行病与卫生统计学系, 北京 100191
重大疾病流行病学教育部重点实验室(北京大学), 北京 100191 | | | 郑一 | 北京大学公共卫生学院营养与食品卫生学系, 北京 100191 | | | 王斯悦 | 北京大学公共卫生学院流行病与卫生统计学系, 北京 100191
重大疾病流行病学教育部重点实验室(北京大学), 北京 100191 | | | 武轶群 | 北京大学公共卫生学院流行病与卫生统计学系, 北京 100191
重大疾病流行病学教育部重点实验室(北京大学), 北京 100191 | | | 秦雪英 | 北京大学公共卫生学院流行病与卫生统计学系, 北京 100191
重大疾病流行病学教育部重点实验室(北京大学), 北京 100191 | | | 李劲 | 北京大学公共卫生学院流行病与卫生统计学系, 北京 100191
重大疾病流行病学教育部重点实验室(北京大学), 北京 100191 | | | 吴涛 | 北京大学公共卫生学院流行病与卫生统计学系, 北京 100191
重大疾病流行病学教育部重点实验室(北京大学), 北京 100191 | | | 陈大方 | 北京大学公共卫生学院流行病与卫生统计学系, 北京 100191
重大疾病流行病学教育部重点实验室(北京大学), 北京 100191 | | | 王梦莹 | 北京大学公共卫生学院营养与食品卫生学系, 北京 100191
重大疾病流行病学教育部重点实验室(北京大学), 北京 100191 | mywang@bjmu.edu.cn | | 胡永华 | 北京大学公共卫生学院流行病与卫生统计学系, 北京 100191
重大疾病流行病学教育部重点实验室(北京大学), 北京 100191 | |
|
| 摘要点击次数: 381 |
| 全文下载次数: 90 |
| 中文摘要: |
| 目的 探索短期环境空气污染物暴露与动脉僵硬度相关指标之间的关联，并探索肥胖是否对上述关联存在效应修饰作用。方法 基于北京房山家系队列基线资料开展分析。采用研究对象参与调查当天的空气污染物浓度的24 h均值作为污染指标，采用广义加性高斯模型估计短期各项空气污染物（PM2.5、PM10、SO2、NO2、CO）暴露与颈总动脉内膜厚度（CIMT）、脉搏波传导速度（BAPWV）、脉压（PP）和踝肱指数（ABI）的关联。将各项空气污染物和BMI、腰臀比的交叉项纳入模型以检验交互作用，并开展分层分析进一步探索其对短期各项空气污染物暴露与CIMT、BAPWV、PP、ABI关联的影响。结果 共纳入4 211名研究对象进行分析。研究对象年龄为（58.9±8.7）岁，其中2 268名（53.9%）为女性。模型调整社会人口学、生活行为方式、用药史等混杂因素。结果显示，PM2.5 （β=2.912×10-4，95%CI：1.424×10-4~4.400×10-4，P<0.001）、CO（β=0.027，95%CI：0.011~0.043，P<0.001）、SO2（β=2.070×10-3，95%CI：7.060×10-4~3.430×10-3，P=0.003）、NO2（β=3.650×10-4，95%CI：2.340×10-5~7.060×10-4，P=0.036）4种污染浓度增加与CIMT水平升高有关。PM10 （β=0.018，95%CI：0.002~0.033，P=0.028）浓度增加与PP水平升高有关。研究未发现短期空气污染物暴露与ABI、BAPWV水平存在关联。腰臀比对短期PM2.5（交互作用P=0.015）、NO2（交互作用P=0.008）、CO（交互作用P=0.044）暴露与CIMT的关联存在效应修饰作用；对短期PM2.5（交互作用P=0.002）、NO2（交互作用P=0.010）、CO（交互作用P=0.029）、PM10 （交互作用P<0.001）暴露与PP的关联存在效应修饰作用，腰臀比较低的人群中空气污染物浓度升高相关的CIMT、PP升高更显著。结论 短期暴露于多种空气污染物与CIMT、PP等动脉僵硬度指标存在关联，腰臀比对此关联存在效应修饰作用，较低腰臀比可能会增强空气污染物暴露与指标的关联。 |
| 英文摘要: |
| Objective To assess the association between short-term ambient air pollution exposure and arterial stiffness and whether obesity modifies these associations. Methods A cross-sectional study was conducted based on Fangshan family cohort in Beijing. The 24 hours average air pollutant levels on the day cohort participants took baseline survey were calculated as short-term air pollution. A generalized additive model (GAM) with Gaussian links was used to estimate changes in typical carotid artery intima-media thickness (CIMT), brachial-ankle pulse wave velocity (BAPWV), pulse pressure (PP) and ankle-branchial index (ABI) after short-term exposure to each air pollution (PM2.5, PM10, SO2, NO2, CO). The cross-product terms of each air pollution, body mass index (BMI), and waist-to-hip ratio were included in the GAM model to test the interaction. Further, they conducted a stratified analysis to test their effects on the relationship between short-term exposure to each air pollution and the arterial stiffness indicators. Results A total of 4 211 individuals were included in the analysis. Individuals' age was (58.9±8.7) years, of which 2 268 (53.9%) were female. Several covariates, including sociodemographic factors, lifestyle behaviors, and history of drugs, were included in the analysis. The results of the GAM analysis showed that an increase in PM 2.5 (β =2.912×10-4, 95%CI: 1.424×10-4-4.400×10-4, P<0.001), CO (β = 0.027, 95%CI: 0.011-0.043, P<0.001), SO2 (β =2.070×10-3, 95%CI: 7.060×10-4-3.430×10-3, P=0.003), and NO 2 (β=3.650×10-4, 95%CI: 2.340×10-5-7.060×10-4, P=0.036) were associated with an increase in CIMT, while an increase in PM10 (β =0.018, 95%CI: 0.002-0.033, P=0.028) was associated with an increase in PP in the study population. Besides, the waist-to-hip ratio had an effect-modification on the correlation of short-term exposure of PM2.5 (interaction P=0.015), NO2 (interaction P=0.008), and CO (interaction P=0.044) with CIMT, and the correlation between short-term exposure of PM2.5 (interaction P=0.002), NO2 (interaction P=0.010), CO (interaction P=0.029), PM10 (interaction P< 0.001) with PP. The significant association between CIMT, PP, and air pollution concentrations was more visible in people with lower waist-to-hip ratios. Conclusions Short-term ambient air pollution exposure was associated with arterial stiffness indicators, and there was an effect modification of waist-to-hip ratio on these associations, and lower waist-to-hip ratios may enhance the association between air pollution exposure and indicators. |
|
查看全文
Html全文
查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
|
|
|
