| 蒋安琪,魏玥,梁博,裴丽君.中国中老年人可能肌少症与衰弱发生风险关联的队列研究[J].中华流行病学杂志,2025,46(1):81-86 |
| 中国中老年人可能肌少症与衰弱发生风险关联的队列研究 |
| Association between possible sarcopenia and risk for frailty in middle-aged and elderly adults in China: a cohort study |
| 收稿日期:2024-08-23 出版日期:2025-01-11 |
| DOI：10.3760/cma.j.cn112338-20240823-00517 |
| 中文关键词: 衰弱 可能肌少症 中老年人 |
| 英文关键词: Frailty Possible sarcopenia Middle-aged and older adults |
| 基金项目:国家重点研发计划（2018YFC2000603）；国家自然科学基金（41871360） |
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| 中文摘要: |
| 目的 探讨中国中老年人可能肌少症与衰弱发生风险的关联。方法 利用2011-2018年中国健康与养老追踪调查数据，采用前瞻性队列研究，以2011年9 007名未发生衰弱的中老年人作为基线人群，分别于2013、2015、2018年随访衰弱结局。使用衰弱指数评价中老年人的衰弱状况，通过测量握力和重复5次起坐时间判断可能肌少症。采用Cox比例风险回归模型分析中老年人可能肌少症与衰弱发生风险的关联。结果 共随访44 884人年，发生衰弱586名，发病密度为13.06/1 000人年。年龄≥60岁（HR=2.05，95%CI：1.71~2.45）、文化程度为小学以下（HR=1.55，95%CI：1.29~1.85）、腰高比≥0.5（HR=1.39，95%CI：1.11~1.75）和有抑郁情绪（HR=1.52，95%CI：1.28~1.81）使中老年人衰弱发生风险增加；有饮酒习惯可能降低衰弱发生风险（HR=0.76，95%CI：0.62~0.94）。患有可能肌少症使中老年人衰弱发生风险增加（HR=1.73，95%CI：1.47~2.05）。结论 中国中老年人患有可能肌少症、年龄偏高、文化程度较低、中心性肥胖和有抑郁情绪会增加其衰弱发生风险，针对潜在的高危人群应尽早采取干预措施，延缓衰弱的发生发展。 |
| 英文摘要: |
| Objective To assess the association between possible sarcopenia and the risk for frailty in middle-aged and elderly adults in China. Methods A prospective cohort study design was used in this study. Data were from the China Health and Retirement Longitudinal Study during 2011-2018 and the baseline data in 2011, the follow up was conducted in 2013, 2015 and 2018, respectively. Frailty index was used to evaluate frailty status, and grip strength and repetitive sitting-up time were measured to detect possible sarcopenia. Cox proportional hazards regression model was used to estimate the association between possible sarcopenia and the risk for frailty in middle-aged and older adults. Results In a 44 884 person-years follow-up, a total of 586 cases with frailty were recorded, and the incidence density of frailty was 13.06 per 1 000 person-year. The risk for frailty was also higher in those who were aged 60 years and above (HR=2.05, 95%CI: 1.71-2.45), had a primary school education level or below (HR=1.55, 95%CI: 1.29-1.85), had waist-to-height ratio ≥0.5 (HR=1.39, 95%CI: 1.11-1.75) and had depression (HR=1.52, 95%CI: 1.28-1.81). Drinking was associated with reduced risk for frailty (HR=0.76, 95%CI: 0.62-0.94). The risk for frailty increased (HR=1.73, 95%CI: 1.47-2.05) in those who might has possible sarcopenia. Conclusions In middle-aged and elderly adults, those with possible sarcopenia, lower education level, central obesity and depression might be at high risk for frailty, and early interventions for high-risk population can be taken to slow the progression of frailty. |
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