| 吕子全,杨彦波,张宇,姚相杰,卢雪梅,付玉林,王夕冉,扈庆华,邹旋.病原体基因组数据库在公共卫生中的发展及应用[J].中华流行病学杂志,2025,46(9):1697-1703 |
| 病原体基因组数据库在公共卫生中的发展及应用 |
| Pathogen genome databases development and application in public health |
| 收稿日期:2024-12-27 出版日期:2025-09-12 |
| DOI：10.3760/cma.j.cn112338-20241227-00830 |
| 中文关键词: 流行病学 病原体 基因组 公共卫生 数据库 |
| 英文关键词: Epidemiology Pathogens Genome Public health Databases |
| 基金项目:国家科技重大专项（2023ZD0510105）；深圳市心脑肺相关重大慢性病队列研究，深圳市医学研究专项资金-人群队列研究（C2302001）；深圳市“医疗卫生三名工程”（SZSM202011008）；深圳市医学重点学科（SZXK066）；深圳市自然科学基金（JCYJ20210324124201004）；深圳市技术创新计划（JSGG20220606141800001） |
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| 中文摘要: |
| 传染性疾病对全球公共卫生构成持续威胁。新发和再现病原体引发的全球性冲击不断挑战现有监测系统，凸显了构建高效、精准的病原体监测网络的迫切性。病原体基因组学数据库在过去20年中迅速发展，显著提升了病原体的分子鉴定、进化分析和传播追踪能力，改变了疾病监测的策略与格局。本文旨在回顾病原体基因组学数据库的发展历程与现状，并深入探讨其在病原体变异监测、疑难病原鉴定和流行病学溯源等公共卫生领域的应用。此外，本文还系统分析了当前全球卫生防控体系的局限性及面临的关键挑战，提出建议并展望未来病原体数据库的发展方向，以弥补现有不足，进一步增强全球传染病的监测与预警能力。 |
| 英文摘要: |
| Infectious diseases continue to pose a threat to global public health. Successive global shocks caused by emerging and re-emerging pathogens have continuously challenged existing surveillance systems, highlighting the urgent need to build efficient and precise pathogen surveillance networks. Pathogen genomic databases have been developed rapidly in recent two decades, significantly improving the molecular identification, evolutionary analysis, and transmission tracking of pathogens, and changing disease surveillance strategies and patterns. This paper summarizes the developmental history and current state of pathogen genomic databases, and discusses their applications in public health, including pathogen variation surveillance, emerging or suspected pathogen identification, and epidemiological tracing. Furthermore, this paper systematically analyzes the limitations and key challenges faced by current global health prevention and control system, and suggests the focus of the development of online pathogen databases to address existing shortcomings, ultimately improve global infectious disease surveillance and early warning |
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