| 左莹莹,姜妍妍,耿聪,陶兴永,严双琴,高国朋,黄锟,伍晓艳,陶芳标,童娟.产前钡暴露与儿童脂肪重积聚时相提前的关联研究[J].中华流行病学杂志,2025,46(12):2179-2185 |
| 产前钡暴露与儿童脂肪重积聚时相提前的关联研究 |
| Study of the association of prenatal barium exposure and advancement of the adiposity rebound phase in children |
| 收稿日期:2025-05-20 出版日期:2025-12-22 |
| DOI：10.3760/cma.j.cn112338-20250520-00333 |
| 中文关键词: 钡 儿童 脂肪重积聚 队列研究 |
| 英文关键词: Barium Children Adiposity rebound Cohort study |
| 基金项目:国家自然科学基金（82304167）；安徽省高校自然科学研究项目（2023AH050559） |
| 作者 | 单位 | E-mail | | 左莹莹 | 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系/出生人口健康教育部重点实验室/安徽省环境与人口健康重点实验室, 合肥 230032 | | | 姜妍妍 | 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系/出生人口健康教育部重点实验室/安徽省环境与人口健康重点实验室, 合肥 230032 | | | 耿聪 | 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系/出生人口健康教育部重点实验室/安徽省环境与人口健康重点实验室, 合肥 230032 | | | 陶兴永 | 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系/出生人口健康教育部重点实验室/安徽省环境与人口健康重点实验室, 合肥 230032 | | | 严双琴 | 马鞍山市妇幼保健院, 马鞍山 243000 | | | 高国朋 | 马鞍山市妇幼保健院, 马鞍山 243000 | | | 黄锟 | 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系/出生人口健康教育部重点实验室/安徽省环境与人口健康重点实验室, 合肥 230032 | | | 伍晓艳 | 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系/出生人口健康教育部重点实验室/安徽省环境与人口健康重点实验室, 合肥 230032 | | | 陶芳标 | 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系/出生人口健康教育部重点实验室/安徽省环境与人口健康重点实验室, 合肥 230032 | | | 童娟 | 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系/出生人口健康教育部重点实验室/安徽省环境与人口健康重点实验室, 合肥 230032 | tongjuan@ahmu.edu.cn |
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| 中文摘要: |
| 目的 探讨产前钡暴露对儿童脂肪重积聚时相提前的影响。方法 研究纳入来自马鞍山优生优育队列的2 718对母子对，采集孕妇孕早、中和晚期外周静脉血及新生儿脐带血并检测母子对血清钡浓度。在儿童出生后42 d、3月龄、6月龄、9月龄、1岁、1.5岁、2岁、2.5岁、3岁、3.5岁、4岁、4.5岁、5岁、5.5岁、6岁和7岁测量其身长/身高、体重等并计算BMI。采用分式多项式混合效应模型拟合儿童BMI轨迹并确定儿童脂肪重积聚时相。利用二分类logistic回归模型评估产前钡暴露与儿童脂肪重积聚时相提前的关联。采用相乘模型来评估产前钡暴露和儿童性别的交互作用对儿童脂肪重积聚时相提前的影响。结果 所有儿童、男童和女童脂肪重积聚时相提前的人数分别占87.42%、86.58%和88.30%。在调整混杂因素之后，二分类logistic回归结果显示，孕早期钡暴露分别与所有儿童（OR=1.20，95%CI：1.03~1.40）、男童（OR=1.30，95%CI：1.06~1.58）的脂肪重积聚时相提前有统计学关联。然而，在女童中并未发现任何相似的关联。相乘交互作用结果显示，产前钡暴露和儿童性别的交互作用对脂肪重积聚时相提前没有显著影响。结论 孕早期钡暴露可能会导致儿童脂肪重积聚时相提前的风险增加，且这种影响在男童中更明显。但交互分析并未显示存在统计学关联，性别差异需谨慎解释。 |
| 英文摘要: |
| Objective To explore the effect of prenatal barium exposure on the advancement of the adiposity rebound phase in children. Methods We included 2 718 mother-child pairs from the Ma'anshan Birth Cohort in this study. Peripheral venous blood from pregnant women during pregnancy and umbilical cord blood from newborns were collected and tested for serum barium concentrations in mother-child pairs. Length/height and weight were measured, and body mass index (BMI) was calculated at 42 days, 3 months, 6 months, 9 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 3.5 years, 4 years, 4.5 years, 5 years, 5.5 years, 6 years, and 7 years of age. A fractional polynomial mixed-effects model was used to fit the children's BMI trajectories and to determine the timing of adiposity rebound. Binary logistic regression models were used to assess the association between prenatal barium exposure and the advancement of the adiposity rebound phase. The multiplicative model was applied to analyze the effect of the interaction between prenatal barium exposure and child sex on the advancement of the adiposity rebound phase in children. Results The detection rates of adiposity rebound phase advancement were 87.42%, 86.58%, and 88.30% for all children, boys, and girls, respectively. After adjusting for confounders, binary logistic regression revealed that barium exposure in the first trimester was statistically associated with the advancement of adiposity rebound in all children (OR=1.20, 95%CI: 1.03-1.40) and boys (OR=1.30, 95%CI: 1.06-1.58), respectively. However, no similar associations were found in girls. The multiplicative interaction results showed that the interaction between barium exposure during pregnancy and child sex did not have a significant effect on the advancement of the adiposity rebound phase. Conclusions Barium exposure in the first trimester may lead to an increased risk of adiposity rebound phase advancement in children, and this effect was more pronounced in boys. However, interaction analyses did not reveal a statistically significant association, so sex-specific differences in children need to be interpreted with caution. |
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