| 年云鹏,宁少奇,栗珊珊,余鹏博,梦遥,赵翔,任瑞琪,燕婧,韩骁禺,郑振兴,张巧凤,王鑫,张义.中国北方地区首例人感染甲型H10N3禽流感病毒病例的调查处置[J].中华流行病学杂志,2026,47(2):275-280 |
| 中国北方地区首例人感染甲型H10N3禽流感病毒病例的调查处置 |
| Investigation and management of the first case of human infection with avian influenza A(H10N3) virus in northern China |
| 收稿日期:2025-06-16 出版日期:2026-02-13 |
| DOI：10.3760/cma.j.cn112338-20250616-00397 |
| 中文关键词: 禽流感病毒 人感染禽流感 流行病学 |
| 英文关键词: Avian influenza virus Human infection with avian influenza Epidemiology |
| 基金项目: |
| 作者 | 单位 | E-mail | | 年云鹏 | 陕西省疾病预防控制中心传染病预防控制所, 西安 710054 | | | 宁少奇 | 陕西省疾病预防控制中心传染病预防控制所, 西安 710054 | | | 栗珊珊 | 陕西省疾病预防控制中心地方病预防控制所, 西安 710054 | | | 余鹏博 | 陕西省疾病预防控制中心病毒病预防控制所, 西安 710054 | | | 梦遥 | 陕西省疾病预防控制中心病毒病预防控制所, 西安 710054 | | | 赵翔 | 中国疾病预防控制中心病毒病预防控制所, 北京 102206 | | | 任瑞琪 | 中国疾病预防控制中心卫生应急中心, 北京 102206 | | | 燕婧 | 陕西省疾病预防控制中心消毒与病媒生物防治所, 西安 710054 | | | 韩骁禺 | 陕西省疾病预防控制中心病毒病预防控制所, 西安 710054 | | | 郑振兴 | 榆林市疾病预防控制中心传染病控制科, 榆林 719000 | | | 张巧凤 | 榆阳区疾病预防控制中心传染病控制科, 榆林 719000 | | | 王鑫 | 陕西省疾病预防控制中心传染病预防控制所, 西安 710054 | | | 张义 | 陕西省疾病预防控制中心传染病预防控制所, 西安 710054
1 陕西省疾病预防控制中心传染病预防控制所, 西安 710054 | 8826970@qq.com |
|
| 摘要点击次数: 4179 |
| 全文下载次数: 548 |
| 中文摘要: |
| 目的 分析中国北方地区首例人感染甲型H10N3禽流感病毒病例的流行病学特征及现场调查情况，为今后人感染动物源性流感病例的调查和处置提供参考。方法 开展病例流行病学个案调查，共同暴露者、密切接触者判定和医学观察，进行传染源溯源调查分析。采集病例、共同暴露者、密切接触者、禽类及外环境样本，采用实时荧光定量RT-PCR法检测甲型流感病毒，对病例阳性样本进行宏基因组测序并进行比对。结果 病例为我国北方地区首例人感染甲型H10N3禽流感病毒病例，系主动就诊经第三方实验室检测发现。病例2025年4月13日发病，发病前无类似症状病例接触史，有禽类养殖史，4月28日肺泡灌洗液样本宏基因组检测为甲型H10N3禽流感病毒阳性。采集共同暴露者、密切接触者、禽类及外环境样本共168份，甲型H10N3禽流感病毒检测均为阴性。宏基因组测序分析发现，与我国广西壮族自治区2024年12月报告的人感染甲型H10N3禽流感病毒病例序列同源性较高。在采取密切接触者医学观察、病家家禽无害化处理、可疑暴露场所消毒等应急处置措施后未出现续发病例，5月14日病例经治疗痊愈出院。结论 中国北方地区首例人感染甲型H10N3禽流感病例感染来源尚不十分明确，但未发现人际传播。提高甲型H10N3禽流感等新亚型动物源性流感病毒监测的敏感性，增强卫生和畜牧部门的联防联控，对科学防控人感染动物源性流感至关重要。 |
| 英文摘要: |
| Objective To summarize and analyze the epidemiological characteristics and field investigation of the first case of human infection with avian influenza A(H10N3) virus in northern China and to provide reference for the investigation and management of human infection with animal-derived influenza in the future. Methods Case epidemiological investigation, identification and medical observation of co-exposed people and close contacts, and tracing investigation and analysis of infection source were carried out. Samples were collected from the case, co-exposed persons, close contacts, poultry, and the external environment. Real-time fluorescent quantitative RT-PCR was used to detect influenza A virus. The positive samples were subjected to metagenomic sequencing and compared. Results This is the first case of human infection with the avian influenza A(H10N3) virus in northern China, and a third-party laboratory performed the detection. The patient became ill on April 13, 2025, with no history of contact with similar cases prior to symptom onset but with a history of exposure to poultry. The macrogene test of bronchoalveolar lavage fluid was positive for avian influenza A(H10N3) virus on April 28, 2025. A total of 168 samples were collected from co-exposed individuals, close contacts, poultry, and the external environment, and all were negative for avian influenza A(H10N3) virus. Metagenomic sequencing analysis showed that the sequence had high homology with the human infection case of avian influenza A(H10N3) virus reported in Guangxi Zhuang Autonomous Region in December 2024. After taking emergency measures such as medical observation of close contacts, harmless treatment of poultry in the sick home, and disinfection of suspected exposure places, no secondary cases occurred. The case was cured and discharged on May 14. Conclusions The source of the first human case of avian influenza A(H10N3) infection in northern China remains unclear, but no human-to-human transmission has been found. It is important to improve the sensitivity of surveillance for new subtypes of animal-derived influenza viruses, such as avian influenza A(H10N3), and to strengthen joint prevention and control between health and animal husbandry departments to support scientific approaches to preventing and controlling human infection with these viruses. |
|
查看全文
Html全文
查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
|
|
|
