| 翁婷婷,高国朋,贾晓敏,王琼瑶,严双琴,童娟,陶芳标.母亲妊娠前体重和妊娠期糖尿病与儿童孤独症样行为的关联研究[J].中华流行病学杂志,2026,47(3):495-500 |
| 母亲妊娠前体重和妊娠期糖尿病与儿童孤独症样行为的关联研究 |
| Association of maternal prepregnancy overweight and gestational diabetes with autistic-like behaviors in children |
| 收稿日期:2025-07-01 出版日期:2026-03-19 |
| DOI：10.3760/cma.j.cn112338-20250701-00448 |
| 中文关键词: 妊娠期糖尿病|超重|孤独症谱系障碍|出生队列研究 |
| 英文关键词: Gestational diabetes|Overweight|Autism spectrum disorder|Birth Cohort Study |
| 基金项目:安徽省卫生健康科研项目（AHWJ2023A30018） |
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| 中文摘要: |
| 目的 探讨妊娠前超重、肥胖与妊娠期糖尿病（GDM）与儿童孤独症样行为的关联性。方法 选取2013年5月至2014年9月建立的马鞍山优生优育出生队列数据，分别于妊娠早、中、晚期收集包括妊娠前体重、身高、妊娠期增重以及妊娠并发症等信息，随访至儿童18月龄时进行孤独症样行为筛查，采用logistic回归模型分析妊娠前超重/肥胖和GDM与儿童孤独症样行为的相关性，并通过相乘和相加交互作用分析探讨母亲妊娠前超重/肥胖及GDM对儿童孤独症样行为是否存在交互作用。结果 队列中孕妇GDM和妊娠前超重分别为401名（12.9%）和309名（9.7%）。儿童18月龄孤独症样行为筛查阳性432名，阳性率为13.8%。Logistic回归分析结果显示，母亲GDM（OR=1.41，95%CI：1.06~1.88）、妊娠前超重（OR=1.43，95%CI：1.04~1.97）均与儿童孤独症样行为呈正相关。母亲GDM合并妊娠前超重/肥胖与儿童孤独症样行为相关性更高（OR=2.42，95%CI：1.50~3.90），母亲GDM和妊娠前超重/肥胖对儿童孤独症样行为存在相乘交互作用（OR=2.29，95%CI：1.42~3.69）。结论 母亲妊娠前超重/肥胖和GDM可能增加儿童发生孤独症样行为的风险，应重视妊娠前体重管理以及妊娠期高危因素暴露儿童的健康管理。 |
| 英文摘要: |
| Objective To investigate the association of prepregnancy overweight/obesity and gestational diabetes mellitus (GDM) with autistic-like behaviors in children. Methods The data from the Ma'anshan Birth Cohort between May 2013 and September 2014 were used,the information about prepregnancy weight, height, gestational weight gain, and pregnancy complications were collected in the first, second, and third trimesters. Children were screened for autistic-like behaviors at 18 months of age. Logistic regression models were used to analyze the association of prepregnancy overweight/obesity and GDM with autistic-like behaviors in children. Multiplicative and additive interaction analyses were conducted to explore potential interactive effects of maternal prepregnancy overweight/obesity and GDM on autistic-like behaviors risk. Results In the cohort, 401 cases (12.9%) of GDM and 309 cases (9.7%) of prepregnancy overweight were detected, respectively. A total of 432 cases (13.8%) children were screened to be positive for autism-like behaviors at 18 months of age. Logistic regression analysis revealed that both GDM and prepregnancy overweight/obesity showed significant positive associations with autistic-like behaviors in children (OR=1.41, 95%CI: 1.06-1.88; OR=1.43, 95%CI: 1.04-1.97). GDM complicated with prepregnancy overweight/obesity had a higher association with autistic-like behaviors in children (OR=2.42, 95%CI: 1.50-3.90), multiplicative interaction model analysis showed significant interactive effect between GDM and prepregnancy overweight/obesity on autistic-like behaviors risk in children (OR=2.29,95%CI:1.42-3.69). Conclusions Prepregnancy overweight/obesity and GDM might increase the risk for social developmental disorders in children. Close attention should be paied to prepregnancy weight management and health monitoring for children exposed to these high-risk prenatal factors. |
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